$265 Cheap Flights from San Diego (SAN) to Santiago (SCL)

View $265 flight on Fri, Dec 12, 2025Opens in a new window

Popular airlines from San Diego Intl. Airport (SAN) to Santiago Intl. Airport (SCL)

Cheap Flights from San Diego to Santiago (SAN-SCL)

Prices were available within the past 7 days and start at $265 for one-way flights and $551 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Fri, Nov 7 - Sun, Nov 9
SAN
San Diego
SCL
Santiago
$551 Roundtrip, found 1 day ago
$551
Roundtrip
found 1 day ago
Select Copa flight, departing Fri, Nov 7 from San Diego to Santiago, returning Sun, Nov 9, priced at $551 found 1 day ago
United
Sun, Nov 2 - Sun, Nov 9
SAN
San Diego
SCL
Santiago
$554 Roundtrip, found 6 days ago
$554
Roundtrip
found 6 days ago
Select United flight, departing Sun, Nov 2 from San Diego to Santiago, returning Sun, Nov 9, priced at $554 found 6 days ago
Copa
Mon, Nov 10 - Mon, Nov 17
SAN
San Diego
SCL
Santiago
$557 Roundtrip, found 2 days ago
$557
Roundtrip
found 2 days ago
Select Copa flight, departing Mon, Nov 10 from San Diego to Santiago, returning Mon, Nov 17, priced at $557 found 2 days ago
Delta
Mon, Nov 10 - Tue, Nov 11
SAN
San Diego
SCL
Santiago
$560 Roundtrip, found 4 days ago
$560
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Nov 10 from San Diego to Santiago, returning Tue, Nov 11, priced at $560 found 4 days ago
Copa
Mon, Nov 3 - Wed, Nov 5
SAN
San Diego
SCL
Santiago
$562 Roundtrip, found 1 day ago
$562
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Nov 3 from San Diego to Santiago, returning Wed, Nov 5, priced at $562 found 1 day ago
United
Sun, Nov 2 - Sun, Nov 9
SAN
San Diego
SCL
Santiago
$563 Roundtrip, found 6 days ago
$563
Roundtrip
found 6 days ago
Select United flight, departing Sun, Nov 2 from San Diego to Santiago, returning Sun, Nov 9, priced at $563 found 6 days ago
American Airlines
Wed, Nov 26 - Tue, Dec 2
SAN
San Diego
SCL
Santiago
$563 Roundtrip, found 15 hours ago
$563
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Nov 26 from San Diego to Santiago, returning Tue, Dec 2, priced at $563 found 15 hours ago
United
Thu, Nov 27 - Wed, Dec 17
SAN
San Diego
SCL
Santiago
$564 Roundtrip, found 6 days ago
$564
Roundtrip
found 6 days ago
Select United flight, departing Thu, Nov 27 from San Diego to Santiago, returning Wed, Dec 17, priced at $564 found 6 days ago
American Airlines
Fri, Nov 28 - Fri, Dec 12
SAN
San Diego
SCL
Santiago
$568 Roundtrip, found 18 hours ago
$568
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Fri, Nov 28 from San Diego to Santiago, returning Fri, Dec 12, priced at $568 found 18 hours ago
LATAM Airlines Group
Thu, Nov 27 - Thu, Dec 11
SAN
San Diego
SCL
Santiago
$589 Roundtrip, found 5 hours ago
$589
Roundtrip
found 5 hours ago
Select LATAM Airlines Group flight, departing Thu, Nov 27 from San Diego to Santiago, returning Thu, Dec 11, priced at $589 found 5 hours ago

Find the cheapest month to fly from San Diego (SAN) to Santiago (SCL)

September is typically the cheapest month to fly

From $502 - $1,051 per traveler.

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $574
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $574
Flights from San Diego (SAN) to Santiago (SCL)
Origin airport
San Diego Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, United
Roundtrip price
$551
Distance
5474 mi

San Diego to Santiago Flights

The cheapest times to fly from San Diego to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Diego to Santiago are during the month of November. You can find some of the cheapest flights from San Diego to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Diego to Santiago

Sunday is one of the best days to book for cheap flights from San Diego to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Diego to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Diego to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $265 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Diego to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Diego to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL) cost?
Grab a cheap one-way flight from $265 or cheap return flight from $551 from San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL)?
November is the least expensive month to fly from SAN to SCL. Traveling during an off-peak travel window is often the key to finding better deals on flights.
What is the cheapest airline that flies from San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL)?
To find the cheapest airline that'll fly you from SAN to SCL, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL)?
There are no daily nonstop flights from San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from SAN to SCL?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can vary depending on a number of factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL) route, aim to fly before 3 PM. Flights after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL) last-minute?
Last-minute bookings from SAN to SCL are generally more expensive. To lock in the lowest rates, start looking for flights well in advance. That being said, if you're flexible with your travel plans, it's possible to find a cheap ticket right before you leave.
Is it cheaper to book a SAN to SCL flight and hotel package?
You can save money by securing a SAN to SCL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've selected your preferred flights and accommodations, consider adding extras including car rentals, activities and tours.
Can I cancel or change the date of my flight from San Diego Intl. Airport (SAN) to Arturo Merino Benitez Airport (SCL)?
In most cases, you're able to cancel or reschedule your SAN to SCL flight. However, there may be additional charges, especially if you made your booking over 24 hours ago. Double-check your itinerary for the airline's guidelines and fees on flight changes, or if you need further details, go to our Customer Service portal.

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*Available to One Key members.