$353 Cheap Flights from San Francisco (SFO) to Tupelo (TUP)

View $353 flight on Sat, Nov 15, 2025Opens in a new window

Popular airlines from San Francisco Intl. Airport (SFO) to Tupelo, MS (TUP-Tupelo Regional)

Cheap Flights from San Francisco to Tupelo (SFO-TUP)

Prices were available within the past 7 days and start at $353 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP) cost?
Lock in a cheap one-way flight from $353 or cheap return flight from San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP)?
The cheapest month to fly from SFO to TUP is , when demand is low. Off-peak season is usually when airlines offer better prices between these airports.
What is the cheapest airline that flies from San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP)?
Use the filter tool on Expedia to compare different airlines and find the cheapest carrier that'll take you from SFO to TUP. Then, sort your results by "Price (lowest to highest)" to snap up a good deal.
How many flights per day from San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP)?
You'll need to take a flight with a layover if you're traveling from San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from SFO to TUP?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary based on a number of factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP)?
To avoid potential delays on the San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP) route, travel before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP) last-minute?
Last-minute bookings from SFO to TUP are generally more expensive. To secure the best rates, start looking for flights as soon as possible. That being said, if you're flexible with your travel dates, you may find a cheap ticket right before your journey.
Is it cheaper to book a SFO to TUP flight and hotel package?
You'll typically save money by securing a SFO to TUP flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one convenient place. Once you've selected your ideal flights and accommodations, you can add extras like car rentals, activities and tours.
Can I cancel or change the date of my flight from San Francisco Intl. Airport (SFO) to Tupelo Regional Airport (TUP)?
Typically, you can reschedule or cancel your SFO to TUP flight. However, there may be additional fees, especially if you booked more than 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you'd like more information, go to our Customer Service portal.

Travel information

Origin airport
San Francisco Intl.
Destination airport
Tupelo Regional
Distance
1884 mi

Book with confidence

San Francisco to Tupelo Flights

The cheapest times to fly from San Francisco to Tupelo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Francisco to Tupelo are during the month of . You can find some of the cheapest flights from San Francisco to Tupelo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Francisco to Tupelo

Sunday is one of the best days to book for cheap flights from San Francisco to Tupelo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Francisco to Tupelo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Francisco to Tupelo in 2025. You can also book with separate airlines for your outbound and return journeys, from $353 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Francisco to Tupelo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Francisco to Tupelo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

San Francisco to Tupelo Flights

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*Available to One Key members.