$480 Cheap Flights from St. Louis (STL) to Santiago (SCL)

View $480 flight on Mon, Nov 10, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Santiago Intl. Airport (SCL)

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Cheap Flights from St. Louis to Santiago (STL-SCL)

Prices were available within the past 7 days and start at $480 for one-way flights and $804 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$804 Roundtrip, found 1 hour ago
$804
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $804 found 1 hour ago
Delta
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$804 Roundtrip, found 1 hour ago
$804
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $804 found 1 hour ago
United
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$804 Roundtrip, found 1 hour ago
$804
Roundtrip
found 1 hour ago
Select United flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $804 found 1 hour ago
American Airlines
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$808 Roundtrip, found 1 hour ago
$808
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $808 found 1 hour ago
Delta
Sun, Nov 2 - Mon, Nov 17
STL
St. Louis
SCL
Santiago
$812 Roundtrip, found 2 days ago
$812
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Nov 2 from St. Louis to Santiago, returning Mon, Nov 17, priced at $812 found 2 days ago
American Airlines
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$814 Roundtrip, found 1 hour ago
$814
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $814 found 1 hour ago
Delta
Sun, Dec 7 - Thu, Dec 18
STL
St. Louis
SCL
Santiago
$816 Roundtrip, found 5 days ago
$816
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Dec 7 from St. Louis to Santiago, returning Thu, Dec 18, priced at $816 found 5 days ago
American Airlines
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$819 Roundtrip, found 1 hour ago
$819
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $819 found 1 hour ago
LATAM Airlines Group
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$868 Roundtrip, found 1 hour ago
$868
Roundtrip
found 1 hour ago
Select LATAM Airlines Group flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $868 found 1 hour ago
Copa
Wed, Aug 13 - Tue, Sep 2
STL
St. Louis
SCL
Santiago
$900 Roundtrip, found 5 days ago
$900
Roundtrip
found 5 days ago
Select Copa flight, departing Wed, Aug 13 from St. Louis to Santiago, returning Tue, Sep 2, priced at $900 found 5 days ago

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $1,164
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $1,164
Flights from St. Louis (STL) to Santiago (SCL)
Origin airport
Lambert-St. Louis Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, United, avianca
Roundtrip price
$803
Distance
5139 mi

St. Louis to Santiago Flights

The cheapest times to fly from St. Louis to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Santiago are during the month of November. You can find some of the cheapest flights from St. Louis to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Santiago

Sunday is one of the best days to book for cheap flights from St. Louis to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $480 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL) cost?
Discover the latest flight deals from STL to SCL by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from STL to SCL?
The cheapest flights from STL to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from STL to SCL?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from STL to SCL. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
There are no daily direct flights departing from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way in no time at all.
What day of the week has the most flights from STL to SCL?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on a range of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
To touch down at Arturo Merino Benitez Airport (SCL) on schedule, pick a flight that takes off from Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your flight from STL to SCL right before your journey is usually more expensive. However, if you're flexible with your schedule, you could score a cheap last-minute fare.
Is it cheaper to book a STL to SCL flight and hotel package?
You'll generally save money by securing a STL to SCL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. After selecting your preferred accommodations and flights, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
You can usually cancel or reschedule your STL to SCL flight. However, if it's been more than 24 hours since booking, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.