$346 Cheap Flights from Knoxville (TYS) to Meridian (MEI)

View $346 flight on Thu, Dec 25, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Meridian, MS (MEI-Meridian Regional)

Cheap Flights from Knoxville to Meridian (TYS-MEI)

Prices were available within the past 7 days and start at $346 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI) cost?
Grab a cheap one-way flight from $346 or cheap return flight from McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI)?
is the least expensive month to fly from TYS to MEI. Avoiding peak travel times is often the key to better flight prices.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI)?
Use the filter tool on Expedia to compare different airlines and find the cheapest carrier that'll fly you from TYS to MEI. Then, sort your results by "Price (lowest to highest)" to snap up a good deal.
How many flights per day from McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI)?
There are no daily direct flights from McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI). But you can choose flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from TYS to MEI?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can vary based on various factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI)?
To avoid potential delays on the McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI) route, aim to fly before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI) last-minute?
Holding off until just before your departure to book a ticket from TYS to MEI often results in higher prices. While you may find some last-minute discounts, there's no guarantee. Be flexible with your travel plans to boost your chances of getting a bargain.
Is it cheaper to book a TYS to MEI flight and hotel package?
Compared with arranging flights and hotels separately, booking a TYS to MEI flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one easy place takes the hassle out of planning your trip. Simply pick your flights and select from our extensive range of stays, then tailor your trip with extras like tours and car rentals.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Meridian Regional Airport (MEI)?
Generally, it's possible to cancel or reschedule your TYS to MEI flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
McGhee Tyson
Destination airport
Meridian Regional
Distance
362 mi

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Knoxville to Meridian Flights

The cheapest times to fly from Knoxville to Meridian

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Meridian are during the month of . You can find some of the cheapest flights from Knoxville to Meridian with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Meridian

Sunday is one of the best days to book for cheap flights from Knoxville to Meridian: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Meridian

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Meridian in 2026. You can also book with separate airlines for your outbound and return journeys, from $346 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Meridian flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Meridian airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Meridian Flights

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*Available to One Key members.