$144 Cheap American Airlines flights Des Moines (DSM) to Amarillo (AMA)

Landing cheap one-way American Airlines flights from DSM to AMA from $144 on Expedia couldn’t be easier — just filter by “Price (lowest to highest).” Or check out our budget-friendly return fares from $297 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for return or one-way flights to Amarillo in February or January. You could find an affordable fare with American Airlines during these quieter months.

To find cheap American Airlines fares from Des Moines Intl. Airport (DSM) to Rick Husband Amarillo Intl. Airport (AMA), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact how much you pay. Sunday tends to be the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Simply enter your dates, press search and check the “Nonstop” filter on Expedia to find any direct flights from DSM to AMA with American Airlines or other carriers.

Browse American Airlines’s earliest flights from DSM to AMA by checking our “Early Morning” and “Morning” filters. Not only will you get to your destination sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Des Moines Intl. Airport (DSM) to Amarillo come in to land at Rick Husband Amarillo Intl. Airport (AMA). This is the main entry point to this city.

It’s usually possible to cancel or change your flight, although there may be additional charges if you made your booking over 24 hours ago. Need flexible options? Apply the “No cancel fee” and “Changes included” filters to find flights that won’t penalize you if you need to revise your plans. To update your itinerary, head to “Trips,” select your flight and click on “Manage Booking” for more details.