$144 Cheap American Airlines flights Harrisburg (MDT) to Chicago (ORD)

Landing cheap one-way American Airlines flights from MDT to ORD from $144 on Expedia is simple — just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares from $209 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for cheap American Airlines flights from Harrisburg Intl. Airport (MDT) to O'Hare Intl. Airport (ORD) one to three months prior to your departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and itinerary, the best day of the week to book a domestic flight is generally Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The first flight from MDT to ORD with American Airlines departs at 7:41AM UTC-5. You'll land at 9:10AM UTC-6. The final American Airlines flight of the day takes off at 12:30PM UTC-5 and arrives at 1:57PM UTC-6. With approximately 20% fewer cancellations for morning and mid-morning departures, heading out early is often the smartest choice.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.