$130 Cheap American Airlines flights Key West (EYW) to Indianapolis (IND)

Landing cheap one-way American Airlines flights from EYW to IND from $130 on Expedia is simple — just filter by “Price (lowest to highest).” Or check out our budget-friendly round-trip fares from $229 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the most affordable months to get away to Indianapolis with American Airlines. You could also find great prices on return and one-way tickets in November.

Look for cheap American Airlines flights from Key West Intl. Airport (EYW) to Indianapolis Intl. Airport (IND) one to three months before your departure date. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and journey, the best day to book a domestic flight is usually Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To find out if there’s a direct route from EYW to IND with American Airlines or another airline, check the “Nonstop” filter when searching for flights.

Find American Airlines’s earliest flights from EYW to IND by checking the “Early Morning” and “Morning” filters. Not only will you arrive at your destination sooner, early departures also experience 20% fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Key West Intl. Airport (EYW) to Indianapolis come in to land at Indianapolis Intl. Airport (IND). This is the main entry point to this city.

In most cases, you can cancel or reschedule your flight, although there may be a charge if your booking was made more than 24 hours ago. Prefer to keep your options open? Use our “No cancel fee” and “Changes included” filters to find flights that won’t penalize you if you have to adjust your plans. To make modifications, head to “Trips,” select your flight and click on “Manage Booking” for more information.