$190 Cheap American Airlines flights Knoxville (TYS) to Philadelphia (PHL)

Landing cheap one-way American Airlines flights from TYS to PHL from $190 on Expedia is simple --- just filter by "Price (lowest to highest)." Or check out our budget-friendly return fares from $355 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for cheap American Airlines flights from McGhee Tyson Airport (TYS) to Philadelphia Intl. Airport (PHL) one to three months ahead of your departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and itinerary, the best day to book a domestic flight is generally Sunday and the most expensive tends to be Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The first flight from TYS to PHL with American Airlines leaves at 7:56AM UTC-5. You'll touch down at 9:50AM UTC-5. The last American Airlines flight of the day takes off at 6:15PM UTC-5 and arrives at 8:07PM UTC-5. With 20% fewer cancellations for departures before noon, jetting out early is generally the smartest option.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.