$294 Cheap American Airlines flights Rochester (RST) to Key West (EYW)

Scoring cheap one-way American Airlines flights from RST to EYW from $294 on Expedia is easy — just filter by "Price (lowest to highest)." Or check out our affordable round-trip fares from $278 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Begin your search one to three months ahead of your departure date to get cheaper fares on American Airlines flights from Rochester Intl. Airport (RST) to Key West Intl. Airport (EYW). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic journeys.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departures from RST to EYW with American Airlines, sort your results by "Early Morning" and "Morning." Choosing an early flight generally means you'll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.