$191 Cheap Delta flights Knoxville (TYS) to Detroit (DTW)

Finding cheap one-way Delta Air Lines flights from TYS to DTW from $191 on Expedia is a breeze — just filter by "Price (lowest to highest)." Alternatively, check out our affordable return fares from $299 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Begin your search one to three months ahead of your travel date to get cheap fares on Delta Air Lines flights from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Taking off from TYS at 7:25AM UTC-5, the earliest Delta Air Lines flight to DTW lands at 9:15AM UTC-5. Traveling earlier in the day means you're less likely to encounter delays or cancellations.* Prefer to travel later? The last Delta Air Lines flight from TYS to DTW departs at 1:00PM UTC-5 and touches down at 2:51PM UTC-5.*Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

Offering an excellent in-flight experience and a rewarding loyalty program, Delta Air Lines is a favorite for many passengers heading from TYS to DTW. Plus, if you're a Delta SkyMiles and One Key™ member booking with Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which can be put toward future travel purchases.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.