$129 Cheap United flights Knoxville (TYS) to Chicago (ORD)

Scoring cheap one-way United Airlines flights from TYS to ORD from $129 on Expedia is a breeze — just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly return fares from $194 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Start searching one to three months before your departure to score cheap fares on United Airlines flights from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing right, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The earliest United Airlines flight from TYS to ORD departs at 6:20AM UTC-5, arriving at 7:27AM UTC-6. If you prefer to jet off later, the last United Airlines flight leaves TYS at 5:47PM UTC-5 and lands at ORD at 6:50PM UTC-6. Flying early is generally a good option as morning flights are least likely to face cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

With a rewarding loyalty program, United Airlines is a favorite of many travelers heading from TYS to ORD. Plus, as a United Mileage Plus and One Key™ member booking through Expedia, you can earn OneKeyCash™* on eligible flights on top of your airline miles.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.