$304 Cheap Flights from Mexico City (MEX) to Santiago (SCL)

View $304 flight on Mon, Jan 5, 2026Opens in a new window

Popular airlines from Benito Juarez International Airport (MEX) to Santiago Intl. Airport (SCL)

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Cheap Flights from Mexico City to Santiago (MEX-SCL)

Prices were available within the past 7 days and start at $304 for one-way flights and $563 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, Oct 2 - Mon, Oct 13
MEX
Mexico City
SCL
Santiago
$563 Roundtrip, found 1 hour ago
$563
Roundtrip
found 1 hour ago
Select Copa flight, departing Thu, Oct 2 from Mexico City to Santiago, returning Mon, Oct 13, priced at $563 found 1 hour ago
Aeromexico
Tue, Nov 25 - Wed, Dec 24
MEX
Mexico City
SCL
Santiago
$601 Roundtrip, just found
$601
Roundtrip
just found
Select Aeromexico flight, departing Tue, Nov 25 from Mexico City to Santiago, returning Wed, Dec 24, priced at $601 just found
avianca
Thu, Oct 2 - Mon, Oct 13
MEX
Mexico City
SCL
Santiago
$602 Roundtrip, found 1 hour ago
$602
Roundtrip
found 1 hour ago
Select avianca flight, departing Thu, Oct 2 from Mexico City to Santiago, returning Mon, Oct 13, priced at $602 found 1 hour ago
LATAM Airlines Group
Tue, Nov 25 - Wed, Dec 24
MEX
Mexico City
SCL
Santiago
$610 Roundtrip, just found
$610
Roundtrip
just found
Select LATAM Airlines Group flight, departing Tue, Nov 25 from Mexico City to Santiago, returning Wed, Dec 24, priced at $610 just found
United
Tue, Nov 18 - Wed, Jan 28
MEX
Mexico City
SCL
Santiago
$1,291 Roundtrip, just found
$1,291
Roundtrip
just found
Select United flight, departing Tue, Nov 18 from Mexico City to Santiago, returning Wed, Jan 28, priced at $1,291 just found
American Airlines
Tue, Nov 18 - Wed, Jan 28
MEX
Mexico City
SCL
Santiago
$1,520 Roundtrip, just found
$1,520
Roundtrip
just found
Select American Airlines flight, departing Tue, Nov 18 from Mexico City to Santiago, returning Wed, Jan 28, priced at $1,520 just found
Air Canada
Tue, Jan 20 - Wed, Jan 28
MEX
Mexico City
SCL
Santiago
$1,721 Roundtrip, found 23 hours ago
$1,721
Roundtrip
found 23 hours ago
Select Air Canada flight, departing Tue, Jan 20 from Mexico City to Santiago, returning Wed, Jan 28, priced at $1,721 found 23 hours ago
Aerolineas Argentinas
Tue, Feb 10 - Wed, Feb 25
MEX
Mexico City
SCL
Santiago
$1,731 Roundtrip, found 3 days ago
$1,731
Roundtrip
found 3 days ago
Select Aerolineas Argentinas flight, departing Tue, Feb 10 from Mexico City to Santiago, returning Wed, Feb 25, priced at $1,731 found 3 days ago
Delta
Thu, Sep 4 - Thu, Sep 11
MEX
Mexico City
SCL
Santiago
$2,627 Roundtrip, found 18 hours ago
$2,627
Roundtrip
found 18 hours ago
Select Delta flight, departing Thu, Sep 4 from Mexico City to Santiago, returning Thu, Sep 11, priced at $2,627 found 18 hours ago

Find the cheapest month to fly from Mexico City (MEX) to Santiago (SCL)

May is typically the cheapest month to fly

From $379 - $700 per traveler.

Graph displaying average flight prices per month

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $730
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $730
Flights from Mexico City (MEX) to Santiago (SCL)
Origin airport
Mexico City Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Aerolineas Argentinas, Aeromexico, Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, United, avianca
Roundtrip price
$563
Distance
4098 mi
Average flight time
7 hours 40 mins

Mexico City to Santiago Flights

The cheapest times to fly from Mexico City to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mexico City to Santiago are during the month of October. You can find some of the cheapest flights from Mexico City to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mexico City to Santiago

Sunday is one of the best days to book for cheap flights from Mexico City to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mexico City to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mexico City to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $304 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mexico City to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mexico City to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) cost?
Snag a cheap one-way flight from $304 or cheap return flight from $563 from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
October is the cheapest month to fly from MEX to SCL. Planning your trip for the off-season is often the key to scoring lower fares.
Which airlines fly direct from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
When flying out of Mexico City Intl. Airport (MEX), you can get on a direct flight to Arturo Merino Benitez Airport (SCL) with LATAM Airlines.
What is the cheapest airline that flies from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
While prices can vary depending on your travel dates, Aeromexico and LATAM Airlines are often among the top picks for flights between Mexico City Intl. Airport (MEX) and Arturo Merino Benitez Airport (SCL). You can also compare airlines on Expedia and use the "Sort by" filter to find the lowest fare for your MEX to SCL flight.
How many flights per day from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
On average, there is just 1 nonstop flight taking off from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) each day. If this doesn't fit your travel plans, think about flights with a layover. Just customize your search results on Expedia to include one or more stops to discover the next best option.
What are the most popular departure times for flights from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
More travelers fly between MEX and SCL at 7 PM than at any other time of day. Looking to skip the crowds? Pick a flight outside the busiest times and you're likely to save on your ticket as well.
What day of the week has the most flights from MEX to SCL?
Travel on a Friday if you're searching for the biggest selection of flights from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL).
What is the earliest flight from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
The earliest flight leaving from Mexico City Intl. Airport (MEX) is at around 10:05AM UTC-6. Hop on this flight and you'll arrive at Arturo Merino Benitez Airport (SCL) at approximately 9:10PM UTC-3. The entire trip takes 8h 5m.
How long does it take to fly from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
Flights from MEX to SCL have an average travel time of 8 hours and 8 minutes. The total distance between these two airports is 4,100 mi.
What airline has the least delays from MEX to SCL?
Consider traveling with LATAM Airlines if you'd like to fly straight from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) without any delays. This carrier has the strongest track record for punctuality, with an on-time performance of 90%. Want to be notified if anything changes? You can keep an eye on your flight status using the Expedia App.
What is the best time to fly from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) route, aim to travel before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santiago from Mexico City Intl. Airport (MEX)?
Arturo Merino Benitez Airport (SCL) is the only airport in Santiago with direct flights from Mexico City Intl. Airport (MEX). Consider your options and discover cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your ticket from MEX to SCL shortly before your getaway is generally more expensive. However, if there's some wiggle room with your schedule, you could snag a cheap last-minute fare.
Is it cheaper to book a MEX to SCL flight and hotel package?
Compared with arranging flights and hotels separately, booking a MEX to SCL flight and hotel package with Expedia could lead to significant savings. What's more, managing everything in one place takes the hassle out of travel planning. Simply secure your flights and choose from our wide range of hotels, then tailor your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Mexico City Intl. Airport (MEX) to Arturo Merino Benitez Airport (SCL)?
If you booked your MEX to SCL flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

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