$155 Cheap Flights from Des Moines (DSM) to Roanoke (ROA)

View $155 flight on Fri, Oct 10, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Roanoke Regional Airport (ROA)

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Cheap Flights from Des Moines to Roanoke (DSM-ROA)

Prices were available within the past 7 days and start at $155 for one-way flights and $249 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Dec 9 - Sat, Dec 13
DSM
Des Moines
ROA
Roanoke
$249 Roundtrip, found 5 hours ago
$249
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Tue, Dec 9 from Des Moines to Roanoke, returning Sat, Dec 13, priced at $249 found 5 hours ago
United
Wed, Sep 10 - Wed, Sep 17
DSM
Des Moines
ROA
Roanoke
$249 Roundtrip, found 2 days ago
$249
Roundtrip
found 2 days ago
Select United flight, departing Wed, Sep 10 from Des Moines to Roanoke, returning Wed, Sep 17, priced at $249 found 2 days ago
American Airlines
Mon, Aug 25 - Mon, Sep 1
DSM
Des Moines
ROA
Roanoke
$254 Roundtrip, found 2 days ago
$254
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Aug 25 from Des Moines to Roanoke, returning Mon, Sep 1, priced at $254 found 2 days ago
Delta
Thu, Nov 27 - Tue, Dec 16
DSM
Des Moines
ROA
Roanoke
$254 Roundtrip, found 2 days ago
$254
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Nov 27 from Des Moines to Roanoke, returning Tue, Dec 16, priced at $254 found 2 days ago
American Airlines
Sat, Aug 23 - Thu, Aug 28
DSM
Des Moines
ROA
Roanoke
$259 Roundtrip, found 4 days ago
$259
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Aug 23 from Des Moines to Roanoke, returning Thu, Aug 28, priced at $259 found 4 days ago
United
Mon, Aug 25 - Mon, Sep 1
DSM
Des Moines
ROA
Roanoke
$259 Roundtrip, found 2 days ago
$259
Roundtrip
found 2 days ago
Select United flight, departing Mon, Aug 25 from Des Moines to Roanoke, returning Mon, Sep 1, priced at $259 found 2 days ago
United
Tue, Sep 9 - Sat, Sep 13
DSM
Des Moines
ROA
Roanoke
$263 Roundtrip, found 6 days ago
$263
Roundtrip
found 6 days ago
Select United flight, departing Tue, Sep 9 from Des Moines to Roanoke, returning Sat, Sep 13, priced at $263 found 6 days ago
United
Tue, Sep 9 - Sat, Sep 13
DSM
Des Moines
ROA
Roanoke
$268 Roundtrip, found 6 days ago
$268
Roundtrip
found 6 days ago
Select United flight, departing Tue, Sep 9 from Des Moines to Roanoke, returning Sat, Sep 13, priced at $268 found 6 days ago
United
Mon, Aug 25 - Mon, Sep 1
DSM
Des Moines
ROA
Roanoke
$273 Roundtrip, found 2 days ago
$273
Roundtrip
found 2 days ago
Select United flight, departing Mon, Aug 25 from Des Moines to Roanoke, returning Mon, Sep 1, priced at $273 found 2 days ago
American Airlines
Tue, Nov 4 - Sun, Nov 16
DSM
Des Moines
ROA
Roanoke
$274 Roundtrip, found 1 day ago
$274
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 4 from Des Moines to Roanoke, returning Sun, Nov 16, priced at $274 found 1 day ago

Alternative airports near Roanoke

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Roanoke Regional ROA. Cheapest and Closest option available. Average driving time to city center is 9 minutes. Flights from $254
ROA
Roanoke Regional
CheapestClosest
Average driving time to city center9 min
Flights from $254
Flights from Des Moines (DSM) to Roanoke (ROA)
Origin airport
Des Moines Intl.
Destination airport
Roanoke Regional
Airlines serving
American Airlines, Delta, United
Roundtrip price
$248
Distance
784 mi

Des Moines to Roanoke Flights

The cheapest times to fly from Des Moines to Roanoke

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Roanoke are during the month of December. You can find some of the cheapest flights from Des Moines to Roanoke with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Roanoke

Sunday is one of the best days to book for cheap flights from Des Moines to Roanoke: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Roanoke

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Roanoke in 2025. You can also book with separate airlines for your outbound and return journeys, from $155 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Roanoke flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Roanoke airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Roanoke Regional Airport (ROA) cost?
Grab a cheap one-way flight from $155 or cheap return flight from $249 from Des Moines Intl. Airport (DSM) to Roanoke Regional Airport (ROA) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Roanoke Regional Airport (ROA)?
The cheapest month to fly from DSM to ROA is December, when demand is low. Off-peak season is often when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Roanoke Regional Airport (ROA)?
To find the cheapest airline that'll fly you from DSM to ROA, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Des Moines Intl. Airport (DSM) to Roanoke Regional Airport (ROA)?
Direct flights from Des Moines Intl. Airport (DSM) to Roanoke Regional Airport (ROA) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to ROA?
Generally you'll find the widest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can change depending on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Roanoke Regional Airport (ROA)?
To arrive at Roanoke Regional Airport (ROA) on time, select a flight that leaves from Des Moines Intl. Airport (DSM) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Roanoke Regional Airport (ROA) last-minute?
Booking your plane ticket from DSM to ROA shortly before your getaway is usually more expensive. But if there's some wiggle room with your itinerary, you could bag a cheap last-minute fare.
Is it cheaper to book a DSM to ROA flight and hotel package?
You'll generally save money by securing a DSM to ROA flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. Once you've chosen your preferred accommodations and flights, you can add extras such as tours, activities and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Roanoke Regional Airport (ROA)?
You can usually cancel or reschedule your DSM to ROA flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.