$24 Cheap Flights from Antofagasta (ANF) to La Serena (LSC)

View $24 flight on Wed, Jul 23, 2025Opens in a new window

Popular airlines from Antofagasta (ANF-Cerro Moreno Intl.) to La Serena (LSC-La Florida)

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Cheap Flights from Antofagasta to La Serena (ANF-LSC)

Prices were available within the past 7 days and start at $24 for one-way flights and $70 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

SKY AIRLINE
Fri, Aug 8 - Wed, Aug 27
ANF
Antofagasta
LSC
La Serena
$70 Roundtrip, found 4 hours ago
$70
Roundtrip
found 4 hours ago
Select SKY AIRLINE flight, departing Fri, Aug 8 from Antofagasta to La Serena, returning Wed, Aug 27, priced at $70 found 4 hours ago
SKY AIRLINE
Fri, Oct 10 - Mon, Oct 13
ANF
Antofagasta
LSC
La Serena
$75 Roundtrip, found 4 hours ago
$75
Roundtrip
found 4 hours ago
Select SKY AIRLINE flight, departing Fri, Oct 10 from Antofagasta to La Serena, returning Mon, Oct 13, priced at $75 found 4 hours ago
SKY AIRLINE
Fri, Aug 8 - Wed, Aug 27
ANF
Antofagasta
LSC
La Serena
$75 Roundtrip, found 4 hours ago
$75
Roundtrip
found 4 hours ago
Select SKY AIRLINE flight, departing Fri, Aug 8 from Antofagasta to La Serena, returning Wed, Aug 27, priced at $75 found 4 hours ago
SKY AIRLINE
Fri, Oct 10 - Mon, Oct 13
ANF
Antofagasta
LSC
La Serena
$77 Roundtrip, found 4 hours ago
$77
Roundtrip
found 4 hours ago
Select SKY AIRLINE flight, departing Fri, Oct 10 from Antofagasta to La Serena, returning Mon, Oct 13, priced at $77 found 4 hours ago
SKY AIRLINE
Fri, Aug 8 - Wed, Aug 27
ANF
Antofagasta
LSC
La Serena
$77 Roundtrip, found 4 hours ago
$77
Roundtrip
found 4 hours ago
Select SKY AIRLINE flight, departing Fri, Aug 8 from Antofagasta to La Serena, returning Wed, Aug 27, priced at $77 found 4 hours ago
Jetsmart SPA
Fri, Oct 10 - Mon, Oct 13
ANF
Antofagasta
LSC
La Serena
$79 Roundtrip, found 4 hours ago
$79
Roundtrip
found 4 hours ago
Select Jetsmart SPA flight, departing Fri, Oct 10 from Antofagasta to La Serena, returning Mon, Oct 13, priced at $79 found 4 hours ago
SKY AIRLINE
Fri, Oct 10 - Mon, Oct 13
ANF
Antofagasta
LSC
La Serena
$81 Roundtrip, found 4 hours ago
$81
Roundtrip
found 4 hours ago
Select SKY AIRLINE flight, departing Fri, Oct 10 from Antofagasta to La Serena, returning Mon, Oct 13, priced at $81 found 4 hours ago
Jetsmart SPA
Fri, Oct 10 - Mon, Oct 13
ANF
Antofagasta
LSC
La Serena
$83 Roundtrip, found 4 hours ago
$83
Roundtrip
found 4 hours ago
Select Jetsmart SPA flight, departing Fri, Oct 10 from Antofagasta to La Serena, returning Mon, Oct 13, priced at $83 found 4 hours ago
Jetsmart SPA
Fri, Oct 10 - Mon, Oct 13
ANF
Antofagasta
LSC
La Serena
$85 Roundtrip, found 4 hours ago
$85
Roundtrip
found 4 hours ago
Select Jetsmart SPA flight, departing Fri, Oct 10 from Antofagasta to La Serena, returning Mon, Oct 13, priced at $85 found 4 hours ago
LATAM Airlines Group
Fri, Aug 8 - Wed, Aug 27
ANF
Antofagasta
LSC
La Serena
$88 Roundtrip, found 4 hours ago
$88
Roundtrip
found 4 hours ago
Select LATAM Airlines Group flight, departing Fri, Aug 8 from Antofagasta to La Serena, returning Wed, Aug 27, priced at $88 found 4 hours ago

Alternative airports near La Serena

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to La Florida LSC. Cheapest and Closest option available. Average driving time to city center is 7 minutes. Flights from $125
LSC
La Florida
CheapestClosest
Average driving time to city center7 min
Flights from $125
Flights from Antofagasta (ANF) to La Serena (LSC)
Origin airport
Cerro Moreno Intl.
Destination airport
La Florida
Airlines serving
Jetsmart SPA, LATAM Airlines Group, SKY AIRLINE
Roundtrip price
$69
Distance
449 mi
Average flight time
1 hour 25 mins

Antofagasta to La Serena Flights

The cheapest times to fly from Antofagasta to La Serena

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Antofagasta to La Serena are during the month of August. You can find some of the cheapest flights from Antofagasta to La Serena with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Antofagasta to La Serena

Sunday is one of the best days to book for cheap flights from Antofagasta to La Serena: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Antofagasta to La Serena

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Antofagasta to La Serena in 2025. You can also book with separate airlines for your outbound and return journeys, from $24 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Antofagasta to La Serena flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Antofagasta to La Serena airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC) cost?
Discover the latest flight deals from ANF to LSC by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from ANF to LSC?
The cheapest flights from ANF to LSC are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC)?
Enjoy an uninterrupted journey to La Florida Airport (LSC). 3 carriers offer direct flights from Cerro Moreno Intl. Airport (ANF), including:

  • JetSMART
  • Sky Airline
  • LATAM Airlines

What is the cheapest airline that flies from ANF to LSC?
With prices starting from $24 for a one-way flight from ANF to LSC, Sky Airlines is currently the cheapest carrier on this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from ANF on September 10 2025. Prices were last updated on June 30 2025 and have not changed since.
How many flights per day from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC)?
When taking off from Cerro Moreno Intl. Airport (ANF), you'll have a choice from an average of 3 daily nonstop flights to La Florida Airport (LSC).
What are the most popular departure times for flights from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC)?
Flights between ANF and LSC are their busiest at 7 AM. If you're after a less crowded experience and possibly cheaper tickets, choose a time outside the usual busy windows.
What day of the week has the most flights from ANF to LSC?
Depart on a Thursday if you're after the biggest selection of flights from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC).
What is the earliest flight from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC)?
Cerro Moreno Intl. Airport (ANF)'s first flight to La Florida Airport (LSC) takes off at approximately 7:30AM UTC-3. With a travel duration of 1h 25m, you'll touch down at around 8:55AM UTC-3.
How long does it take to fly from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC)?
It takes roughly 1 hour and 24 minutes to fly the 450 mi from ANF to LSC.
What airline has the least delays from ANF to LSC?
With 83% of journeys usually landing on schedule, LATAM Airlines has the best on-time performance for direct flights from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC). To keep track of your flight status and receive notifications about any changes, simply head to the Expedia App.
What is the best time to fly from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC)?
To reach La Florida Airport (LSC) on time, pick a flight that takes off from Cerro Moreno Intl. Airport (ANF) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for La Serena from Cerro Moreno Intl. Airport (ANF)?
La Florida Airport (LSC) is the only airport in La Serena with direct flights from Cerro Moreno Intl. Airport (ANF). Browse your options and find cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC) last-minute?
Booking your ticket from ANF to LSC just before your journey is generally more expensive. But if you're flexible with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book an ANF to LSC flight and hotel package?
Booking an ANF to LSC flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Select from our wide range of accommodations and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Cerro Moreno Intl. Airport (ANF) to La Florida Airport (LSC)?
Typically, you can reschedule or cancel your ANF to LSC flight. However, there may be additional fees, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you'd like further information, head to our Customer Service portal.

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*Available to One Key members.