$446 Cheap Flights from Des Moines (DSM) to Brussels (BRU)

View $446 flight on Wed, Dec 3, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Brussels Airport (BRU)

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Cheap Flights from Des Moines to Brussels (DSM-BRU)

Prices were available within the past 7 days and start at $446 for one-way flights and $582 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Canada
Wed, Dec 3 - Wed, Dec 10
DSM
Des Moines
BRU
Brussels
$582 Roundtrip, just found
$582
Roundtrip
just found
Select Air Canada flight, departing Wed, Dec 3 from Des Moines to Brussels, returning Wed, Dec 10, priced at $582 just found
Air Canada
Wed, Dec 3 - Wed, Dec 10
DSM
Des Moines
BRU
Brussels
$605 Roundtrip, just found
$605
Roundtrip
just found
Select Air Canada flight, departing Wed, Dec 3 from Des Moines to Brussels, returning Wed, Dec 10, priced at $605 just found
United
Tue, Apr 21 - Tue, May 5
DSM
Des Moines
BRU
Brussels
$609 Roundtrip, found 4 days ago
$609
Roundtrip
found 4 days ago
Select United flight, departing Tue, Apr 21 from Des Moines to Brussels, returning Tue, May 5, priced at $609 found 4 days ago
Virgin Atlantic
Wed, Nov 19 - Tue, Dec 2
DSM
Des Moines
BRU
Brussels
$610 Roundtrip, found 1 day ago
$610
Roundtrip
found 1 day ago
Select Virgin Atlantic flight, departing Wed, Nov 19 from Des Moines to Brussels, returning Tue, Dec 2, priced at $610 found 1 day ago
Delta
Wed, Aug 6 - Fri, Aug 22
DSM
Des Moines
BRU
Brussels
$610 Roundtrip, found 6 days ago
$610
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Aug 6 from Des Moines to Brussels, returning Fri, Aug 22, priced at $610 found 6 days ago
Air Canada
Wed, Dec 3 - Wed, Dec 10
DSM
Des Moines
BRU
Brussels
$611 Roundtrip, just found
$611
Roundtrip
just found
Select Air Canada flight, departing Wed, Dec 3 from Des Moines to Brussels, returning Wed, Dec 10, priced at $611 just found
Air Canada
Tue, Nov 25 - Tue, Dec 2
DSM
Des Moines
BRU
Brussels
$611 Roundtrip, found 4 days ago
$611
Roundtrip
found 4 days ago
Select Air Canada flight, departing Tue, Nov 25 from Des Moines to Brussels, returning Tue, Dec 2, priced at $611 found 4 days ago
United
Tue, Apr 21 - Tue, May 5
DSM
Des Moines
BRU
Brussels
$612 Roundtrip, found 4 days ago
$612
Roundtrip
found 4 days ago
Select United flight, departing Tue, Apr 21 from Des Moines to Brussels, returning Tue, May 5, priced at $612 found 4 days ago
Virgin Atlantic
Tue, Nov 25 - Tue, Dec 2
DSM
Des Moines
BRU
Brussels
$615 Roundtrip, found 4 days ago
$615
Roundtrip
found 4 days ago
Select Virgin Atlantic flight, departing Tue, Nov 25 from Des Moines to Brussels, returning Tue, Dec 2, priced at $615 found 4 days ago
Lufthansa
Wed, Nov 19 - Tue, Dec 2
DSM
Des Moines
BRU
Brussels
$628 Roundtrip, found 1 day ago
$628
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Wed, Nov 19 from Des Moines to Brussels, returning Tue, Dec 2, priced at $628 found 1 day ago
Flights from Des Moines (DSM) to Brussels (BRU)
Origin airport
Des Moines Intl.
Destination airport
Brussels - National
Airlines serving
Aer Lingus, Air Canada, Air France, American Airlines, British Airways, Delta, Finnair, Iberia, KLM, Lufthansa, Scandinavian Airlines, United, Virgin Atlantic
Roundtrip price
$582
Distance
4380 mi

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU) cost?
Discover the latest flight deals from DSM to BRU by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from DSM to BRU?
The cheapest flights from DSM to BRU are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from DSM to BRU?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from DSM to BRU. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU)?
There are no daily direct flights available from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds in no time.
What day of the week has the most flights from DSM to BRU?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change based on a number of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU)?
To avoid potential delays on the Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU) route, travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU) last-minute?
Booking your ticket from DSM to BRU shortly before your journey is typically more expensive. However, if there's some wiggle room with your travel dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a DSM to BRU flight and hotel package?
You can save money by securing a DSM to BRU flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. After choosing your preferred flights and accommodations, you can add extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Brussels - National Airport (BRU)?
If you reserved your DSM to BRU flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

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