$523 Cheap Flights from Des Moines (DSM) to Palermo (PMO)

View $523 flight on Mon, Oct 20, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Punta Raisi Airport (PMO)

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Cheap Flights from Des Moines to Palermo (DSM-PMO)

Prices were available within the past 7 days and start at $523 for one-way flights and $749 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

British Airways
Sat, Oct 18 - Thu, Nov 20
DSM
Des Moines
PMO
Palermo
$749 Roundtrip, found 4 days ago
$749
Roundtrip
found 4 days ago
Select British Airways flight, departing Sat, Oct 18 from Des Moines to Palermo, returning Thu, Nov 20, priced at $749 found 4 days ago
British Airways
Thu, Oct 16 - Thu, Nov 20
DSM
Des Moines
PMO
Palermo
$794 Roundtrip, found 4 days ago
$794
Roundtrip
found 4 days ago
Select British Airways flight, departing Thu, Oct 16 from Des Moines to Palermo, returning Thu, Nov 20, priced at $794 found 4 days ago
British Airways
Thu, Aug 14 - Wed, Aug 27
DSM
Des Moines
PMO
Palermo
$799 Roundtrip, found 5 days ago
$799
Roundtrip
found 5 days ago
Select British Airways flight, departing Thu, Aug 14 from Des Moines to Palermo, returning Wed, Aug 27, priced at $799 found 5 days ago
British Airways
Wed, Oct 15 - Thu, Nov 20
DSM
Des Moines
PMO
Palermo
$799 Roundtrip, found 4 days ago
$799
Roundtrip
found 4 days ago
Select British Airways flight, departing Wed, Oct 15 from Des Moines to Palermo, returning Thu, Nov 20, priced at $799 found 4 days ago
Delta
Wed, Feb 18 - Tue, Mar 3
DSM
Des Moines
PMO
Palermo
$815 Roundtrip, found 5 days ago
$815
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Feb 18 from Des Moines to Palermo, returning Tue, Mar 3, priced at $815 found 5 days ago
United
Wed, Feb 4 - Mon, Feb 16
DSM
Des Moines
PMO
Palermo
$821 Roundtrip, found 5 days ago
$821
Roundtrip
found 5 days ago
Select United flight, departing Wed, Feb 4 from Des Moines to Palermo, returning Mon, Feb 16, priced at $821 found 5 days ago
Delta
Sun, Feb 8 - Tue, Feb 24
DSM
Des Moines
PMO
Palermo
$821 Roundtrip, found 5 days ago
$821
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Feb 8 from Des Moines to Palermo, returning Tue, Feb 24, priced at $821 found 5 days ago
Delta
Wed, Feb 11 - Tue, Feb 24
DSM
Des Moines
PMO
Palermo
$823 Roundtrip, found 5 days ago
$823
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Feb 11 from Des Moines to Palermo, returning Tue, Feb 24, priced at $823 found 5 days ago
KLM
Mon, Oct 13 - Wed, Nov 19
DSM
Des Moines
PMO
Palermo
$840 Roundtrip, found 4 days ago
$840
Roundtrip
found 4 days ago
Select KLM flight, departing Mon, Oct 13 from Des Moines to Palermo, returning Wed, Nov 19, priced at $840 found 4 days ago
Lufthansa
Mon, Oct 13 - Fri, Nov 21
DSM
Des Moines
PMO
Palermo
$845 Roundtrip, found 4 days ago
$845
Roundtrip
found 4 days ago
Select Lufthansa flight, departing Mon, Oct 13 from Des Moines to Palermo, returning Fri, Nov 21, priced at $845 found 4 days ago

Alternative airports near Palermo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Punta Raisi PMO. Cheapest and Closest option available. Average driving time to city center is 38 minutes. Flights from $861
PMO
Punta Raisi
CheapestClosest
Average driving time to city center38 min
Flights from $861
Flights from Des Moines (DSM) to Palermo (PMO)
Origin airport
Des Moines Intl.
Destination airport
Punta Raisi
Roundtrip price
$749
Distance
5257 mi

Des Moines to Palermo Flights

The cheapest times to fly from Des Moines to Palermo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Palermo are during the month of October. You can find some of the cheapest flights from Des Moines to Palermo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Palermo

Sunday is one of the best days to book for cheap flights from Des Moines to Palermo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Palermo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Palermo in 2025. You can also book with separate airlines for your outbound and return journeys, from $523 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Palermo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Palermo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO) cost?
Secure a cheap one-way flight from $523 or cheap return flight from $749 from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO)?
The cheapest month to fly from DSM to PMO is October, when there's less demand. Off-peak season is typically when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find the carrier with the cheapest DSM to PMO flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO)?
You'll have to catch a flight with a layover when traveling from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from DSM to PMO?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary based on a range of factors, including the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO)?
Opt for a flight from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO) that leaves before 3 PM to reduce the likelihood of delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO) last-minute?
Last-minute bookings from DSM to PMO are typically more expensive. To lock in the lowest prices, start looking for flights ahead of time. That said, if your travel plans are flexible, it's possible to land a cheap fare just before your departure.
Is it cheaper to book a DSM to PMO flight and hotel package?
You can save money by booking a DSM to PMO flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one convenient place. After choosing your ideal accommodations and flights, you can add extras such as car rentals, activities and tours.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Punta Raisi Airport (PMO)?
If you reserved your DSM to PMO flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

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*Available to One Key members.