$82 Cheap Flights from Des Moines (DSM) to Fort Myers (RSW)

View $82 flight on Tue, Nov 18, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Southwest Florida Intl. Airport (RSW)

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Cheap Flights from Des Moines to Fort Myers (DSM-RSW)

Prices were available within the past 7 days and start at $82 for one-way flights and $175 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Sat, Nov 15 - Wed, Nov 19
DSM
Des Moines
RSW
Fort Myers
$175 Roundtrip, found 3 days ago
$175
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Sat, Nov 15 from Des Moines to Fort Myers, returning Wed, Nov 19, priced at $175 found 3 days ago
Southwest Airlines
Tue, Nov 18 - Sat, Nov 22
DSM
Des Moines
RSW
Fort Myers
$190 Roundtrip, found 3 days ago
$190
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Tue, Nov 18 from Des Moines to Fort Myers, returning Sat, Nov 22, priced at $190 found 3 days ago
United
Sat, Nov 15 - Wed, Nov 19
DSM
Des Moines
RSW
Fort Myers
$195 Roundtrip, found 3 days ago
$195
Roundtrip
found 3 days ago
Select United flight, departing Sat, Nov 15 from Des Moines to Fort Myers, returning Wed, Nov 19, priced at $195 found 3 days ago
Delta
Thu, Oct 23 - Tue, Oct 28
DSM
Des Moines
RSW
Fort Myers
$203 Roundtrip, found 6 days ago
$203
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Oct 23 from Des Moines to Fort Myers, returning Tue, Oct 28, priced at $203 found 6 days ago
Southwest Airlines
Sat, Nov 15 - Wed, Nov 19
DSM
Des Moines
RSW
Fort Myers
$208 Roundtrip, found 3 days ago
$208
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Sat, Nov 15 from Des Moines to Fort Myers, returning Wed, Nov 19, priced at $208 found 3 days ago
Southwest Airlines
Fri, Nov 14 - Sat, Nov 15
DSM
Des Moines
RSW
Fort Myers
$209 Roundtrip, found 5 days ago
$209
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Fri, Nov 14 from Des Moines to Fort Myers, returning Sat, Nov 15, priced at $209 found 5 days ago
United
Mon, Oct 13 - Sat, Nov 15
DSM
Des Moines
RSW
Fort Myers
$210 Roundtrip, found 5 days ago
$210
Roundtrip
found 5 days ago
Select United flight, departing Mon, Oct 13 from Des Moines to Fort Myers, returning Sat, Nov 15, priced at $210 found 5 days ago
Southwest Airlines
Tue, Nov 18 - Sat, Nov 22
DSM
Des Moines
RSW
Fort Myers
$210 Roundtrip, found 3 days ago
$210
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Tue, Nov 18 from Des Moines to Fort Myers, returning Sat, Nov 22, priced at $210 found 3 days ago
Delta
Sat, Oct 11 - Sat, Nov 1
DSM
Des Moines
RSW
Fort Myers
$217 Roundtrip, found 3 days ago
$217
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, Oct 11 from Des Moines to Fort Myers, returning Sat, Nov 1, priced at $217 found 3 days ago
American Airlines
Thu, Dec 4 - Tue, Dec 9
DSM
Des Moines
RSW
Fort Myers
$224 Roundtrip, found 4 days ago
$224
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Dec 4 from Des Moines to Fort Myers, returning Tue, Dec 9, priced at $224 found 4 days ago

Find the cheapest month to fly from Des Moines (DSM) to Fort Myers (RSW)

August is typically the cheapest month to fly

From $191 - $680 per traveler.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW) cost?
Lock in a cheap one-way flight from $82 or cheap return flight from $175 from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW)?
Flying in November is a good way to save, as it's the cheapest month for flights between DSM and RSW. You'll often find the lowest prices during the off-season.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find the carrier with the cheapest DSM to RSW flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW)?
You'll need to take a flight with a layover if you're traveling from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from DSM to RSW?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can vary depending on various factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW)?
Choose a flight from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW) that takes off before 3 PM to reduce the risk of cancellations and delays. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Fort Myers from Des Moines Intl. Airport (DSM)?
Check out your flight options from Des Moines Intl. Airport (DSM) to Charlotte County Airport (PGD). This is the only airport in Fort Myers you can arrive at if you're taking a direct flight.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW) last-minute?
Holding off until just before your trip to book a ticket from DSM to RSW generally means paying more. While you may find some last-minute deals, they're not always guaranteed. Be flexible with your travel plans to maximize your chances of landing a bargain.
Is it cheaper to book a DSM to RSW flight and hotel package?
Compared with arranging flights and hotels separately, booking a DSM to RSW flight and hotel package with Expedia could lead to significant savings. What's more, having it all in one place takes the hassle out of travel planning. Simply pick your flights and choose from our extensive range of stays, then personalize your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW)?
If you booked your DSM to RSW flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more information.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Southwest Florida Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$174
Distance
1237 mi

Book with confidence

Book with confidence

Des Moines to Fort Myers Flights

The cheapest times to fly from Des Moines to Fort Myers

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Fort Myers are during the month of November. You can find some of the cheapest flights from Des Moines to Fort Myers with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Fort Myers

Sunday is one of the best days to book for cheap flights from Des Moines to Fort Myers: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Fort Myers

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Fort Myers in 2025. You can also book with separate airlines for your outbound and return journeys, from $82 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Fort Myers flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Fort Myers airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Fort Myers Flights

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Explore a world of travel with Expedia

*Available to One Key members.