$543 Cheap Flights from Des Moines (DSM) to Santiago (SCL)

View $543 flight on Wed, Feb 25, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Santiago Intl. Airport (SCL)

Cheap Flights from Des Moines to Santiago (DSM-SCL)

Prices were available within the past 7 days and start at $543 for one-way flights and $764 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Mon, Feb 9 - Thu, Feb 19
DSM
Des Moines
SCL
Santiago
$764 Roundtrip, found 20 hours ago
$764
Roundtrip
found 20 hours ago
Select United flight, departing Mon, Feb 9 from Des Moines to Santiago, returning Thu, Feb 19, priced at $764 found 20 hours ago
United
Mon, Feb 9 - Wed, Feb 25
DSM
Des Moines
SCL
Santiago
$769 Roundtrip, found 20 hours ago
$769
Roundtrip
found 20 hours ago
Select United flight, departing Mon, Feb 9 from Des Moines to Santiago, returning Wed, Feb 25, priced at $769 found 20 hours ago
American Airlines
Tue, Dec 9 - Tue, Dec 16
DSM
Des Moines
SCL
Santiago
$772 Roundtrip, found 6 days ago
$772
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 9 from Des Moines to Santiago, returning Tue, Dec 16, priced at $772 found 6 days ago
United
Mon, Feb 9 - Tue, Feb 24
DSM
Des Moines
SCL
Santiago
$773 Roundtrip, found 20 hours ago
$773
Roundtrip
found 20 hours ago
Select United flight, departing Mon, Feb 9 from Des Moines to Santiago, returning Tue, Feb 24, priced at $773 found 20 hours ago
American Airlines
Tue, Dec 9 - Tue, Dec 16
DSM
Des Moines
SCL
Santiago
$775 Roundtrip, found 6 days ago
$775
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 9 from Des Moines to Santiago, returning Tue, Dec 16, priced at $775 found 6 days ago
Delta
Mon, Dec 15 - Tue, Dec 23
DSM
Des Moines
SCL
Santiago
$777 Roundtrip, found 1 day ago
$777
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Dec 15 from Des Moines to Santiago, returning Tue, Dec 23, priced at $777 found 1 day ago
LATAM Airlines Group
Mon, Jan 19 - Mon, Jan 26
DSM
Des Moines
SCL
Santiago
$784 Roundtrip, just found
$784
Roundtrip
just found
Select LATAM Airlines Group flight, departing Mon, Jan 19 from Des Moines to Santiago, returning Mon, Jan 26, priced at $784 just found
Delta
Sat, Jan 17 - Thu, Jan 22
DSM
Des Moines
SCL
Santiago
$787 Roundtrip, found 4 days ago
$787
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Jan 17 from Des Moines to Santiago, returning Thu, Jan 22, priced at $787 found 4 days ago
LATAM Airlines Group
Thu, Feb 19 - Mon, Mar 9
DSM
Des Moines
SCL
Santiago
$789 Roundtrip, found 3 days ago
$789
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Thu, Feb 19 from Des Moines to Santiago, returning Mon, Mar 9, priced at $789 found 3 days ago
Copa
Tue, Dec 9 - Tue, Dec 16
DSM
Des Moines
SCL
Santiago
$1,512 Roundtrip, found 6 days ago
$1,512
Roundtrip
found 6 days ago
Select Copa flight, departing Tue, Dec 9 from Des Moines to Santiago, returning Tue, Dec 16, priced at $1,512 found 6 days ago

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $1,311
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $1,311
Flights from Des Moines (DSM) to Santiago (SCL)
Origin airport
Des Moines Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, United
Roundtrip price
$764
Distance
5376 mi

Des Moines to Santiago Flights

The cheapest times to fly from Des Moines to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Santiago are during the month of February. You can find some of the cheapest flights from Des Moines to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Santiago

Sunday is one of the best days to book for cheap flights from Des Moines to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Santiago in 2026. You can also book with separate airlines for your outbound and return journeys, from $543 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL) cost?
Lock in a cheap one-way flight from $543 or cheap return flight from $764 from Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL)?
February is the least expensive month to fly from DSM to SCL. Timing your trip outside of the busy season is often the key to finding better deals on flights.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL)?
Use the filter tool on Expedia to compare different airlines and find the most affordable carrier that'll fly you from DSM to SCL. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL)?
There aren't any daily direct flights from Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL). But you can book flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from DSM to SCL?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL) route, fly before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL) last-minute?
Waiting until just before your departure to book a flight from DSM to SCL generally means paying more. While it's possible to find some last-minute deals, they're not always guaranteed. Be flexible with your itinerary to maximize your chances of snagging a bargain.
Is it cheaper to book a DSM to SCL flight and hotel package?
You'll generally save money by securing a DSM to SCL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. After choosing your preferred flights and accommodations, consider adding extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Arturo Merino Benitez Airport (SCL)?
If you booked your DSM to SCL flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

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*Available to One Key members.