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$309 Cheap Flights from Des Moines (DSM) to Syracuse (SYR)

View $309 flight on Fri, Dec 25, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Hancock Intl. Airport (SYR)

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Cheap Flights from Des Moines to Syracuse (DSM-SYR)

Prices were available within the past 7 days and start at $309 for one-way flights and $329 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Dec 9 - Sun, Dec 13
DSM
Des Moines
SYR
Syracuse
$329 Roundtrip, found 4 hours ago
$329
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Dec 9 from Des Moines to Syracuse, returning Sun, Dec 13, priced at $329 found 4 hours ago
American Airlines
Wed, Dec 9 - Sun, Dec 13
DSM
Des Moines
SYR
Syracuse
$334 Roundtrip, found 4 hours ago
$334
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Wed, Dec 9 from Des Moines to Syracuse, returning Sun, Dec 13, priced at $334 found 4 hours ago
United
Tue, Oct 20 - Sat, Oct 24
DSM
Des Moines
SYR
Syracuse
$336 Roundtrip, found 13 hours ago
$336
Roundtrip
found 13 hours ago
Select United flight, departing Tue, Oct 20 from Des Moines to Syracuse, returning Sat, Oct 24, priced at $336 found 13 hours ago
United
Tue, Oct 20 - Sat, Oct 24
DSM
Des Moines
SYR
Syracuse
$340 Roundtrip, found 13 hours ago
$340
Roundtrip
found 13 hours ago
Select United flight, departing Tue, Oct 20 from Des Moines to Syracuse, returning Sat, Oct 24, priced at $340 found 13 hours ago
United
Tue, Oct 20 - Sat, Oct 24
DSM
Des Moines
SYR
Syracuse
$342 Roundtrip, found 13 hours ago
$342
Roundtrip
found 13 hours ago
Select United flight, departing Tue, Oct 20 from Des Moines to Syracuse, returning Sat, Oct 24, priced at $342 found 13 hours ago
United
Tue, Oct 20 - Sat, Oct 24
DSM
Des Moines
SYR
Syracuse
$344 Roundtrip, found 13 hours ago
$344
Roundtrip
found 13 hours ago
Select United flight, departing Tue, Oct 20 from Des Moines to Syracuse, returning Sat, Oct 24, priced at $344 found 13 hours ago
United
Tue, Oct 20 - Sat, Oct 24
DSM
Des Moines
SYR
Syracuse
$347 Roundtrip, found 13 hours ago
$347
Roundtrip
found 13 hours ago
Select United flight, departing Tue, Oct 20 from Des Moines to Syracuse, returning Sat, Oct 24, priced at $347 found 13 hours ago
Delta
Wed, Dec 9 - Sun, Dec 13
DSM
Des Moines
SYR
Syracuse
$349 Roundtrip, found 4 hours ago
$349
Roundtrip
found 4 hours ago
Select Delta flight, departing Wed, Dec 9 from Des Moines to Syracuse, returning Sun, Dec 13, priced at $349 found 4 hours ago
United
Sat, Oct 17 - Sat, Oct 24
DSM
Des Moines
SYR
Syracuse
$349 Roundtrip, found 15 hours ago
$349
Roundtrip
found 15 hours ago
Select United flight, departing Sat, Oct 17 from Des Moines to Syracuse, returning Sat, Oct 24, priced at $349 found 15 hours ago
American Airlines
Tue, Oct 20 - Sat, Oct 24
DSM
Des Moines
SYR
Syracuse
$352 Roundtrip, found 13 hours ago
$352
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Oct 20 from Des Moines to Syracuse, returning Sat, Oct 24, priced at $352 found 13 hours ago

Alternative airports near Syracuse

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Hancock Intl. SYR. Cheapest and Closest option available. Average driving time to city center is 9 minutes. Flights from $379
SYR
Hancock Intl.
CheapestClosest
Average driving time to city center9 min
Flights from $379

What you need to know for your flight from Des Moines Intl. to Hancock Intl.

Des Moines (DSM) to Syracuse (SYR) at a glance

Explore a range of flights from Des Moines (DSM) to Syracuse (SYR) on this domestic short-haul route. Compare options across full-service airlines to discover itineraries that align with your budget, schedule, and travel plans. As you prepare to experience the iconic sights and vibrant neighborhoods of Syracuse, find all the essential details for your journey from Des Moines International Airport (DSM) to Hancock International Airport (SYR).

  • Fastest flight duration: around 3h 30m in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 900 miles (1,450 km)
  • Flights per week: around 9 departures on average
  • Typical fares (one-way): economy tickets often range from $125–$455, depending on seasonality and how far ahead you book

Flights from Des Moines International Airport (DSM) to Hancock International Airport (SYR)

Based on the latest traveler bookings, here are the top airlines favored for one-stop flights from Des Moines to Syracuse. Common layover points include O'Hare International Airport (ORD) with approximately a 1 hour and 15 minute stop, Detroit Metropolitan Wayne County Airport (DTW) also around 1 hour and 15 minutes, and Ronald Reagan Washington National Airport (DCA) with a shorter layover of about 45 minutes. This variety gives you the chance to balance price, total travel time, and cabin class to secure the best travel itinerary.

  • Delta: This comprehensive airline provides one-stop service, holding around 42% of the departures on this route. One-way ticket prices generally fall between $130 and $395. The flight duration is about 3 hours and 30 minutes, with the overall travel time, including layover, totaling approximately 4 hours and 45 minutes.
  • American Airlines: Another full-service option, American Airlines accounts for roughly 34% of departures on this route. Their one-way fares typically range from $125 to $460. Passengers can expect an in-flight duration of 3 hours and 30 minutes, with the complete journey time, including layover, being around 4 hours and 45 minutes.
  • United: Offering one-stop service, United Airlines makes up around 24% of the route's departures. One-way fares generally range from $140 to $555. The flight time is about 3 hours and 30 minutes, while the total travel duration, including layover, is approximately 4 hours and 45 minutes.

Travelers flying from Des Moines to Syracuse can upgrade their experience, as Delta provides premium economy class service on this route.

Best time to fly from Des Moines (DSM) to Syracuse (SYR)

The most popular months for travelers flying from Des Moines to Syracuse are February, July, and October, when peak temperatures in Syracuse reach up to 70.5°F in July. If you prefer quieter travel, consider December, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 31.3°F. For better deals, July usually offers the lowest average one-way fare around $203. Flight availability peaks in October, with approximately 11 flights per week, making it easier to find convenient departure times. January has the fewest flights, with approximately 7 flights per week.

  • Cheapest time to fly: July usually offers good deals with average one-way fare around $203, roughly 24% cheaper than the yearly average.
  • Most flight options: October has the highest number of flights from Des Moines to Syracuse, with approximately 11 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January23.9°F (-4.5°C)Low7$283
February25.3°F (-3.7°C)High10$253
March33.3°F (0.7°C)Average8$303
April45.0°F (7.2°C)Average8$275
May57.4°F (14.1°C)Average8$263
June64.8°F (18.2°C)Low8$272
July70.5°F (21.4°C)High9$203
August68.9°F (20.5°C)Average8$284
September62.4°F (16.9°C)Average9$245
October51.8°F (11.0°C)High11$254
November39.6°F (4.2°C)Average10$334
December31.3°F (-0.4°C)Low8$251

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

How to find the best prices for flights from Des Moines (DSM) to Syracuse (SYR)

Getting some of the best deals on flights from Des Moines to Syracuse is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually available when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Evening departures (6 PM to 12 AM) often have lower prices, while morning flights (5 AM to 12 PM) are the most popular. Additionally, flying on Saturday tends to be cheaper, although Friday remains the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Hancock International Airport from Des Moines International Airport

Syracuse welcomes travelers from Des Moines with a range of transport options based on price, convenience, and proximity. Syracuse city center is approximately a 10-minute drive (covering about 8 miles) from Hancock International Airport, depending on traffic. Here's how to reach Syracuse efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Syracuse, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
  • Car rental: Renting a car from Hancock International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Hancock International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Hancock International Airport, travelers can easily access several transport options. The Syracuse Airport Bus Stop, a bus station, is located about 0.1 miles away on foot, while the Syracuse Regional Transportation Center, a train station, is approximately 5.8 miles away by car. For those heading to the coast, Syracuse Seaport, a seaport, is around 8.4 miles away by car.

Frequently asked questions

How much does a flight from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) cost?
You can find cheap one-way flights from $309 and cheap return flights from $329 Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) with Expedia. One-way flights typically cost between $236 and $809, and return flights often range between $364 and $1193. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.)?
The cheapest month to fly from DSM to SYR is December when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.)?
Enter DSM to SYR and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.)?
Delta is one of the cheapest airlines offering connecting flights from Des Moines, IA (DSM) to Syracuse, NY (SYR), with round-trip tickets starting from around $344. You can find flights with a layover in various locations. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.)?
To find a cheap flight from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.)?
The earliest flight from Des Moines International Airport (DSM) to Syracuse Hancock International Airport (SYR) typically departs at 5:00 AM, operated by American Airlines. An early departure like this can help you maximize your time in Syracuse. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
How long does it take to fly from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.)?
Flying from DSM to SYR with a connection usually takes about 4 hours 50 minutes, traveling roughly 901 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.)?
You can fly first class between DSM and SYR. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) flight with Expedia?
It's easy to earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Syracuse from Des Moines Intl. (DSM)?
If you're planning to travel to Syracuse from Des Moines Intl. (DSM), you can fly into Hancock Intl. (SYR) Some flights may connect through major hubs like O'Hare Intl. (ORD), Denver Intl. (DEN), LaGuardia (LGA) before reaching Syracuse. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) at the last minute?
Typically, booking a last minute flight from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) flight and hotel package?
Securing a Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.)?
If you booked your Des Moines, IA (DSM-Des Moines Intl.) to Syracuse, NY (SYR-Hancock Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Hancock Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$328
Distance
900 mi

Book with confidence

Des Moines to Syracuse Flights

The cheapest times to fly from Des Moines to Syracuse

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Syracuse are during the month of December. You can find some of the cheapest flights from Des Moines to Syracuse with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Syracuse

Sunday is one of the best days to book for cheap flights from Des Moines to Syracuse: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Syracuse

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Syracuse in 2026. You can also book with separate airlines for your outbound and return journeys, from $309 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Syracuse flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Syracuse airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Syracuse Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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