$336 Cheap Flights from Florence (FLO) to Buffalo (BUF)

View $336 flight on Wed, Dec 31, 2025Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Buffalo Niagara Intl. Airport (BUF)

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Cheap Flights from Florence to Buffalo (FLO-BUF)

Prices were available within the past 7 days and start at $336 for one-way flights and $441 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Dec 31 - Sat, Jan 3
FLO
Florence
BUF
Buffalo
$441 Roundtrip, found 1 day ago
$441
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 31 from Florence to Buffalo, returning Sat, Jan 3, priced at $441 found 1 day ago
American Airlines
Wed, Dec 31 - Sat, Jan 3
FLO
Florence
BUF
Buffalo
$446 Roundtrip, found 1 day ago
$446
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 31 from Florence to Buffalo, returning Sat, Jan 3, priced at $446 found 1 day ago
American Airlines
Sat, Jan 10 - Fri, Jan 16
FLO
Florence
BUF
Buffalo
$475 Roundtrip, found 3 days ago
$475
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Jan 10 from Florence to Buffalo, returning Fri, Jan 16, priced at $475 found 3 days ago
American Airlines
Sat, Jan 10 - Fri, Jan 16
FLO
Florence
BUF
Buffalo
$480 Roundtrip, found 3 days ago
$480
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Jan 10 from Florence to Buffalo, returning Fri, Jan 16, priced at $480 found 3 days ago
American Airlines
Thu, Jan 1 - Tue, Jan 6
FLO
Florence
BUF
Buffalo
$511 Roundtrip, found 1 day ago
$511
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jan 1 from Florence to Buffalo, returning Tue, Jan 6, priced at $511 found 1 day ago
American Airlines
Wed, Dec 31 - Sat, Jan 3
FLO
Florence
BUF
Buffalo
$516 Roundtrip, found 1 day ago
$516
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Dec 31 from Florence to Buffalo, returning Sat, Jan 3, priced at $516 found 1 day ago
American Airlines
Thu, Jan 1 - Sun, Jan 4
FLO
Florence
BUF
Buffalo
$526 Roundtrip, found 1 day ago
$526
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jan 1 from Florence to Buffalo, returning Sun, Jan 4, priced at $526 found 1 day ago
American Airlines
Thu, Jan 1 - Fri, Jan 2
FLO
Florence
BUF
Buffalo
$531 Roundtrip, found 1 day ago
$531
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jan 1 from Florence to Buffalo, returning Fri, Jan 2, priced at $531 found 1 day ago
American Airlines
Fri, Jan 2 - Tue, Jan 6
FLO
Florence
BUF
Buffalo
$537 Roundtrip, found 1 day ago
$537
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 2 from Florence to Buffalo, returning Tue, Jan 6, priced at $537 found 1 day ago
American Airlines
Tue, Dec 30 - Tue, Jan 6
FLO
Florence
BUF
Buffalo
$539 Roundtrip, found 1 day ago
$539
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Dec 30 from Florence to Buffalo, returning Tue, Jan 6, priced at $539 found 1 day ago

Alternative airports near Buffalo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Buffalo Niagara Intl. BUF. Cheapest and Closest option available. Average driving time to city center is 16 minutes. Flights from $537
BUF
Buffalo Niagara Intl.
CheapestClosest
Average driving time to city center16 min
Flights from $537

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF) cost?
Lock in a cheap one-way flight from $336 or cheap return flight from $441 from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF)?
December is the least expensive month to fly from FLO to BUF. Avoiding peak travel times is often the key to finding better fares.
What is the cheapest airline that flies from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll take you from FLO to BUF. Then, sort your results by "Price (lowest to highest)" to snag the best deal available.
How many flights per day from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF)?
You'll need to hop on a flight with a layover if you're traveling from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from FLO to BUF?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF)?
Select a flight from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF) last-minute?
Waiting until just before your trip to book your flight from FLO to BUF generally means paying more. While you may come across some last-minute deals, they aren't always guaranteed. Be flexible with your travel plans for the best chance of landing a bargain.
Is it cheaper to book a FLO to BUF flight and hotel package?
Booking a FLO to BUF flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our extensive range of hotels and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Buffalo Niagara Intl. Airport (BUF)?
In most cases, you're able to reschedule or cancel your FLO to BUF flight. However, there may be additional fees, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you want further information, go to our Customer Service portal.

Travel information

Origin airport
Florence Regional
Destination airport
Buffalo Niagara Intl.
Roundtrip price
$440
Distance
606 mi

Book with confidence

Florence to Buffalo Flights

The cheapest times to fly from Florence to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Buffalo are during the month of December. You can find some of the cheapest flights from Florence to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Buffalo

Sunday is one of the best days to book for cheap flights from Florence to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Buffalo in 2026. You can also book with separate airlines for your outbound and return journeys, from $336 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Florence to Buffalo Flights

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