$398 Cheap Flights from Florence (FLO) to Muscle Shoals (MSL)

View $398 flight on Thu, Oct 30, 2025Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Muscle Shoals, AL (MSL-Northwest Alabama Regional)

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Cheap Flights from Florence to Muscle Shoals (FLO-MSL)

Prices were available within the past 7 days and start at $398 for one-way flights and $588 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Oct 30 - Mon, Nov 3
FLO
Florence
MSL
Muscle Shoals
$588 Roundtrip, found 2 days ago
$588
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Oct 30 from Florence to Muscle Shoals, returning Mon, Nov 3, priced at $588 found 2 days ago
American Airlines
Thu, Oct 30 - Fri, Oct 31
FLO
Florence
MSL
Muscle Shoals
$796 Roundtrip, found 2 days ago
$796
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Oct 30 from Florence to Muscle Shoals, returning Fri, Oct 31, priced at $796 found 2 days ago

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Northwest Alabama Regional Airport (MSL) cost?
Lock in a cheap one-way flight from $398 or cheap return flight from $588 from Florence Regional Airport (FLO) to Northwest Alabama Regional Airport (MSL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Florence Regional Airport (FLO) to Northwest Alabama Regional Airport (MSL)?
October is the least expensive month to fly from FLO to MSL. Traveling outside of peak seasons is often the key to finding a great deal.
What is the cheapest airline that flies from Florence Regional Airport (FLO) to Northwest Alabama Regional Airport (MSL)?
To find the cheapest airline that'll fly you from FLO to MSL, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Florence Regional Airport (FLO) to Northwest Alabama Regional Airport (MSL)?
You'll need to book a flight with a layover if you're traveling from Florence Regional Airport (FLO) to Northwest Alabama Regional Airport (MSL). There are no daily direct flights on this route. However, just filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from FLO to MSL?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Florence Regional Airport (FLO) to Northwest Alabama Regional Airport (MSL)?
To reach Northwest Alabama Regional Airport (MSL) on schedule, choose a flight that leaves Florence Regional Airport (FLO) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Northwest Alabama Regional Airport (MSL) last-minute?
Booking your flight from FLO to MSL just before your trip is usually more expensive. But if you're flexible with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a FLO to MSL flight and hotel package?
Booking a FLO to MSL flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Pick from our impressive range of hotels and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Northwest Alabama Regional Airport (MSL)?
In most cases, you can cancel or modify your FLO to MSL flight. However, there may be additional fees, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's guidelines and fees on flight changes, or if you need more information, head to our Customer Service portal.

Travel information

Origin airport
Florence Regional
Destination airport
Northwest Alabama Regional
Roundtrip price
$588
Distance
450 mi

Book with confidence

Florence to Muscle Shoals Flights

The cheapest times to fly from Florence to Muscle Shoals

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Muscle Shoals are during the month of October. You can find some of the cheapest flights from Florence to Muscle Shoals with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Muscle Shoals

Sunday is one of the best days to book for cheap flights from Florence to Muscle Shoals: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Muscle Shoals

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Muscle Shoals in 2025. You can also book with separate airlines for your outbound and return journeys, from $398 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Muscle Shoals flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Muscle Shoals airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Florence to Muscle Shoals Flights

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