$539 Cheap Flights from Hermosillo (HMO) to Santiago (SCL)

View $539 flight on Tue, Dec 2, 2025Opens in a new window

Popular airlines from Hermosillo, Sonora (HMO-General Ignacio Pesqueira Garcia Intl.) to Santiago Intl. Airport (SCL)

Cheap Flights from Hermosillo to Santiago (HMO-SCL)

Prices were available within the past 7 days and start at $539 for one-way flights and $666 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Thu, Nov 13 - Thu, Nov 20
HMO
Hermosillo
SCL
Santiago
$666 Roundtrip, found 3 days ago
$666
Roundtrip
found 3 days ago
Select Aeromexico flight, departing Thu, Nov 13 from Hermosillo to Santiago, returning Thu, Nov 20, priced at $666 found 3 days ago
Aeromexico
Mon, Nov 24 - Wed, Dec 10
HMO
Hermosillo
SCL
Santiago
$678 Roundtrip, found 6 days ago
$678
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Mon, Nov 24 from Hermosillo to Santiago, returning Wed, Dec 10, priced at $678 found 6 days ago
Aeromexico
Tue, Jan 6 - Tue, Jan 27
HMO
Hermosillo
SCL
Santiago
$682 Roundtrip, found 6 days ago
$682
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Tue, Jan 6 from Hermosillo to Santiago, returning Tue, Jan 27, priced at $682 found 6 days ago
Aeromexico
Wed, Jan 7 - Wed, Jan 28
HMO
Hermosillo
SCL
Santiago
$692 Roundtrip, found 6 days ago
$692
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Wed, Jan 7 from Hermosillo to Santiago, returning Wed, Jan 28, priced at $692 found 6 days ago
Aeromexico
Wed, Jan 7 - Wed, Jan 28
HMO
Hermosillo
SCL
Santiago
$696 Roundtrip, found 6 days ago
$696
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Wed, Jan 7 from Hermosillo to Santiago, returning Wed, Jan 28, priced at $696 found 6 days ago
LATAM Airlines Group
Wed, Jan 7 - Wed, Jan 28
HMO
Hermosillo
SCL
Santiago
$700 Roundtrip, found 6 days ago
$700
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Jan 7 from Hermosillo to Santiago, returning Wed, Jan 28, priced at $700 found 6 days ago
Aeromexico
Sun, Nov 23 - Tue, Dec 9
HMO
Hermosillo
SCL
Santiago
$704 Roundtrip, found 6 days ago
$704
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Sun, Nov 23 from Hermosillo to Santiago, returning Tue, Dec 9, priced at $704 found 6 days ago
LATAM Airlines Group
Wed, Jan 7 - Wed, Jan 28
HMO
Hermosillo
SCL
Santiago
$705 Roundtrip, found 6 days ago
$705
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Wed, Jan 7 from Hermosillo to Santiago, returning Wed, Jan 28, priced at $705 found 6 days ago
Aeromexico
Sun, Jan 4 - Tue, Jan 27
HMO
Hermosillo
SCL
Santiago
$708 Roundtrip, found 6 days ago
$708
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Sun, Jan 4 from Hermosillo to Santiago, returning Tue, Jan 27, priced at $708 found 6 days ago
American Airlines
Mon, Nov 24 - Wed, Dec 10
HMO
Hermosillo
SCL
Santiago
$1,720 Roundtrip, found 6 days ago
$1,720
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Nov 24 from Hermosillo to Santiago, returning Wed, Dec 10, priced at $1,720 found 6 days ago

Frequently asked questions

How much does a flight from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL) cost?
Grab a cheap one-way flight from $539 or cheap return flight from $666 from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL)?
November is the cheapest month to fly from HMO to SCL. Planning your trip for the off-season is often the key to landing a great deal.
What is the cheapest airline that flies from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL)?
To find the cheapest airline that'll fly you from HMO to SCL, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL)?
You'll have to book a flight with a layover if you're traveling from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL). There are no daily direct flights on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from HMO to SCL?
Generally you'll have the most choice when it comes to flights on a Friday. Tuesdays tend to be the quietest.* But this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL)?
Select a flight from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your flight from HMO to SCL right before your trip is typically more expensive. But if you're flexible with your travel times and dates, you could snag a cheap last-minute fare.
Is it cheaper to book a HMO to SCL flight and hotel package?
You'll generally save money by booking a HMO to SCL flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. After selecting your preferred accommodations and flights, consider adding extras such as activities, tours and car rentals.
Can I cancel or change the date of my flight from General Ignacio Pesqueira Garcia Intl. Airport (HMO) to Arturo Merino Benitez Airport (SCL)?
If you reserved your HMO to SCL flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

Travel information

Travel information

Origin airport
General Ignacio Pesqueira Garcia Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
American Airlines, Delta, LATAM Airlines Group
Roundtrip price
$666
Distance
5056 mi

Book with confidence

Book with confidence

Hermosillo to Santiago Flights

The cheapest times to fly from Hermosillo to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Hermosillo to Santiago are during the month of November. You can find some of the cheapest flights from Hermosillo to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Hermosillo to Santiago

Sunday is one of the best days to book for cheap flights from Hermosillo to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Hermosillo to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Hermosillo to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $539 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Hermosillo to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Hermosillo to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Hermosillo to Santiago Flights

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*Available to One Key members.