$326 Cheap Flights from La Crosse (LSE) to Indianapolis (IND)

View $326 flight on Wed, Nov 26, 2025Opens in a new window

Popular airlines from La Crosse, WI (LSE-La Crosse Municipal) to Indianapolis Intl. Airport (IND)

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Cheap Flights from La Crosse to Indianapolis (LSE-IND)

Prices were available within the past 7 days and start at $326 for one-way flights and $468 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Dec 26 - Sun, Jan 4
LSE
La Crosse
IND
Indianapolis
$468 Roundtrip, found 14 hours ago
$468
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Dec 26 from La Crosse to Indianapolis, returning Sun, Jan 4, priced at $468 found 14 hours ago
American Airlines
Wed, Dec 24 - Sun, Jan 4
LSE
La Crosse
IND
Indianapolis
$471 Roundtrip, found 14 hours ago
$471
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Dec 24 from La Crosse to Indianapolis, returning Sun, Jan 4, priced at $471 found 14 hours ago
American Airlines
Fri, Dec 12 - Sat, Dec 27
LSE
La Crosse
IND
Indianapolis
$474 Roundtrip, found 14 hours ago
$474
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Dec 12 from La Crosse to Indianapolis, returning Sat, Dec 27, priced at $474 found 14 hours ago
American Airlines
Tue, Nov 4 - Sat, Nov 22
LSE
La Crosse
IND
Indianapolis
$474 Roundtrip, found 14 hours ago
$474
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Tue, Nov 4 from La Crosse to Indianapolis, returning Sat, Nov 22, priced at $474 found 14 hours ago
American Airlines
Tue, Nov 18 - Wed, Nov 26
LSE
La Crosse
IND
Indianapolis
$480 Roundtrip, found 2 days ago
$480
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Nov 18 from La Crosse to Indianapolis, returning Wed, Nov 26, priced at $480 found 2 days ago
American Airlines
Sat, Nov 15 - Wed, Nov 19
LSE
La Crosse
IND
Indianapolis
$492 Roundtrip, found 2 days ago
$492
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Nov 15 from La Crosse to Indianapolis, returning Wed, Nov 19, priced at $492 found 2 days ago
American Airlines
Thu, Nov 20 - Wed, Nov 26
LSE
La Crosse
IND
Indianapolis
$504 Roundtrip, found 2 days ago
$504
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Nov 20 from La Crosse to Indianapolis, returning Wed, Nov 26, priced at $504 found 2 days ago
American Airlines
Thu, Nov 27 - Sat, Nov 29
LSE
La Crosse
IND
Indianapolis
$508 Roundtrip, found 5 days ago
$508
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Nov 27 from La Crosse to Indianapolis, returning Sat, Nov 29, priced at $508 found 5 days ago
American Airlines
Thu, Nov 27 - Mon, Dec 8
LSE
La Crosse
IND
Indianapolis
$514 Roundtrip, found 14 hours ago
$514
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Thu, Nov 27 from La Crosse to Indianapolis, returning Mon, Dec 8, priced at $514 found 14 hours ago
American Airlines
Fri, Nov 14 - Sat, Nov 15
LSE
La Crosse
IND
Indianapolis
$516 Roundtrip, found 2 days ago
$516
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Nov 14 from La Crosse to Indianapolis, returning Sat, Nov 15, priced at $516 found 2 days ago

Alternative airports near Indianapolis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Indianapolis Intl. IND. Cheapest and Closest option available. Average driving time to city center is 19 minutes. Flights from $514
IND
Indianapolis Intl.
CheapestClosest
Average driving time to city center19 min
Flights from $514

Frequently asked questions

How much does a flight from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND) cost?
Grab a cheap one-way flight from $326 or cheap return flight from $468 from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND)?
Planning your trip for December may help you find better deals, as it's the cheapest month for flights between LSE and IND. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest LSE to IND flight.
How many flights per day from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND)?
Direct flights from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from LSE to IND?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND)?
Select a flight from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND) last-minute?
Booking your plane ticket from LSE to IND shortly before your journey is typically more expensive. But if you're flexible with your departure times and dates, you could bag a cheap last-minute fare.
Is it cheaper to book a LSE to IND flight and hotel package?
Compared with arranging hotels and flights separately, booking a LSE to IND flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one easy place will take the hassle out of travel planning. Simply pick your flights and choose from our wide range of hotels, then personalize your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from La Crosse Municipal Airport (LSE) to Indianapolis Intl. Airport (IND)?
If you booked your LSE to IND flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

Travel information

Origin airport
La Crosse Municipal
Destination airport
Indianapolis Intl.
Airlines serving
American Airlines
Roundtrip price
$462
Distance
384 mi

Book with confidence

La Crosse to Indianapolis Flights

The cheapest times to fly from La Crosse to Indianapolis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from La Crosse to Indianapolis are during the month of December. You can find some of the cheapest flights from La Crosse to Indianapolis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from La Crosse to Indianapolis

Sunday is one of the best days to book for cheap flights from La Crosse to Indianapolis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from La Crosse to Indianapolis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from La Crosse to Indianapolis in 2025. You can also book with separate airlines for your outbound and return journeys, from $326 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap La Crosse to Indianapolis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your La Crosse to Indianapolis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

La Crosse to Indianapolis Flights

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*Available to One Key members.