A large waterfall cascading down a cliff, surrounded by dense forest and rocky terrain.

$203 Cheap Flights from Missoula (MSO) to Buffalo (BUF)

View $203 flight on Tue, Oct 20, 2026Opens in a new window

Popular airlines from Missoula Intl. Airport (MSO) to Buffalo Niagara Intl. Airport (BUF)

Cheap Flights from Missoula to Buffalo (MSO-BUF)

Prices were available within the past 7 days and start at $203 for one-way flights and $359 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Nov 26 - Sun, Dec 6
MSO
Missoula
BUF
Buffalo
$359 Roundtrip, found 2 hours ago
$359
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Nov 26 from Missoula to Buffalo, returning Sun, Dec 6, priced at $359 found 2 hours ago
American Airlines
Fri, Oct 2 - Mon, Oct 5
MSO
Missoula
BUF
Buffalo
$382 Roundtrip, found 3 days ago
$382
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 2 from Missoula to Buffalo, returning Mon, Oct 5, priced at $382 found 3 days ago
Delta
Thu, Nov 26 - Sun, Dec 6
MSO
Missoula
BUF
Buffalo
$420 Roundtrip, found 2 hours ago
$420
Roundtrip
found 2 hours ago
Select Delta flight, departing Thu, Nov 26 from Missoula to Buffalo, returning Sun, Dec 6, priced at $420 found 2 hours ago
American Airlines
Wed, Oct 7 - Sat, Oct 10
MSO
Missoula
BUF
Buffalo
$457 Roundtrip, found 2 days ago
$457
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 7 from Missoula to Buffalo, returning Sat, Oct 10, priced at $457 found 2 days ago
American Airlines
Thu, Nov 26 - Sun, Dec 6
MSO
Missoula
BUF
Buffalo
$460 Roundtrip, found 2 hours ago
$460
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Nov 26 from Missoula to Buffalo, returning Sun, Dec 6, priced at $460 found 2 hours ago
American Airlines
Thu, Nov 26 - Sun, Dec 6
MSO
Missoula
BUF
Buffalo
$469 Roundtrip, found 2 hours ago
$469
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Nov 26 from Missoula to Buffalo, returning Sun, Dec 6, priced at $469 found 2 hours ago
Delta
Thu, Nov 26 - Sun, Dec 6
MSO
Missoula
BUF
Buffalo
$470 Roundtrip, found 2 hours ago
$470
Roundtrip
found 2 hours ago
Select Delta flight, departing Thu, Nov 26 from Missoula to Buffalo, returning Sun, Dec 6, priced at $470 found 2 hours ago
Delta
Thu, Nov 26 - Thu, Dec 3
MSO
Missoula
BUF
Buffalo
$472 Roundtrip, found 5 days ago
$472
Roundtrip
found 5 days ago
Select Delta flight, departing Thu, Nov 26 from Missoula to Buffalo, returning Thu, Dec 3, priced at $472 found 5 days ago
United
Wed, Oct 7 - Sat, Oct 10
MSO
Missoula
BUF
Buffalo
$497 Roundtrip, found 2 days ago
$497
Roundtrip
found 2 days ago
Select United flight, departing Wed, Oct 7 from Missoula to Buffalo, returning Sat, Oct 10, priced at $497 found 2 days ago
Alaska Airlines
Fri, Oct 2 - Mon, Oct 5
MSO
Missoula
BUF
Buffalo
$752 Roundtrip, found 10 hours ago
$752
Roundtrip
found 10 hours ago
Select Alaska Airlines flight, departing Fri, Oct 2 from Missoula to Buffalo, returning Mon, Oct 5, priced at $752 found 10 hours ago

Alternative airports near Buffalo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Buffalo Niagara Intl. BUF. Cheapest and Closest option available. Average driving time to city center is 16 minutes. Flights from $666
BUF
Buffalo Niagara Intl.
CheapestClosest
Average driving time to city center16 min
Flights from $666

What you need to know for your flight from Missoula Intl. to Buffalo Niagara Intl.

Missoula (MSO) to Buffalo (BUF) at a glance

Embark on a journey from Missoula (MSO) to Buffalo (BUF) with a selection of airlines catering to this domestic short-haul route. Explore various options from full-service carriers to identify the best itinerary that aligns with your budget and travel plans, all while discovering the iconic sights and neighborhoods of Buffalo. Get essential information for flights departing from Missoula International Airport (MSO) to Buffalo Niagara International Airport (BUF).

  • Fastest flight duration: around 5h 15m in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 1,700 miles (2,740 km)
  • Flights per week: around 7 departures on average
  • Typical fares (one-way): economy tickets often range from $150–$455, depending on seasonality and how far ahead you book

Flights from Missoula International Airport (MSO) to Buffalo Niagara International Airport (BUF)

Based on recent traveler bookings, here are the top airlines flying from Missoula to Buffalo, often favored for their one-stop services. Popular layover locations include O'Hare International Airport, ORD (approximately 2 hours and 30 minutes), Denver International Airport, DEN (around 1 hour and 15 minutes), and Dallas-Fort Worth International Airport, DFW (also about 1 hour and 15 minutes). This variety allows you to tailor your journey by balancing cost, overall travel time, and cabin class to discover the ideal itinerary.

  • United: This full-service airline provides convenient one-stop travel, with one-way ticket prices generally between $190 and $540. It represents about 53% of flights on this route, featuring an in-flight duration of 5 hours and 15 minutes, leading to a total travel time of approximately 6 hours and 30 minutes, including layover.
  • American Airlines: Another full-service option, American Airlines offers one-stop services with one-way fares typically ranging from $150 to $465. They account for around 40% of departures on this route, with a flight time of 5 hours and 15 minutes and a complete journey duration of about 6 hours and 30 minutes, factoring in layovers.

Alternative route from Missoula (MSO) to Buffalo (BUF)

  • Missoula to Rochester (MSO-ROC): Greater Rochester International Airport (ROC) is located approximately 56 miles from Buffalo Niagara International Airport (BUF). One-way economy fares for this route generally fall between $165 and $490, influenced by the time of year and how early you make your reservation. This route is commonly served by both one-stop and multi-stop flights, primarily connecting through O'Hare International Airport (ORD). Major airlines operating on this route include American Airlines and United.

How to find the best prices for flights from Missoula (MSO) to Buffalo (BUF)

Getting some of the best deals on flights from Missoula to Buffalo is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are typically found when booking at least two months in advance, which aligns with when most travelers make their reservations. Morning departures from 5 AM to 12 PM tend to be less expensive, while afternoon flights from 12 PM to 6 PM are the most popular. Additionally, flying on Friday usually offers lower prices, although Wednesday is the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Buffalo Niagara International Airport from Missoula International Airport

Buffalo welcomes travelers from Missoula with a range of transport options based on price, convenience, and proximity. Here's how to reach Buffalo efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Buffalo, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Buffalo Niagara International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Buffalo Niagara International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
  • Public transportation: From Buffalo Niagara International Airport, Buffalo-Depew Station, a train station, is located about 2.6 miles away by car, while University Station, a metro station, is situated approximately 6.5 miles away by car, making both easily accessible for travelers.

Frequently asked questions

How much does a flight from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) cost?
You can find cheap one-way flights from $203 and cheap return flights from $359 Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) with Expedia. One-way flights typically cost between $385 and $1291, and return flights often range between $517 and $2032. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The cheapest month to fly from MSO to BUF is November when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Enter MSO to BUF and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Missoula, MT (MSO) to Buffalo, NY (BUF) with return tickets starting from around $1,114. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
To find a cheap flight from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from MSO to BUF. To compare more early flights, use the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The most popular departure times for flights from Missoula (MSO) to Buffalo (BUF) are in the early afternoon, from 12pm to 3pm. About 42% of passengers prefer this time window. Many major carriers, including American Airlines, United Airlines and Delta Air Lines, offer flights during this window. This timing is favored as it allows you to travel after a leisurely morning.
How long does it take to fly from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Flights from MSO to BUF with one stop typically take around 6 hours 20 minutes, covering approximately 1,736 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
First class is available on flights from MSO to BUF. First class cabins are available on:

  • Delta Air Lines
  • United Airlines
  • American Airlines

How do I earn miles on a Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight with Expedia?
It's easy to earn miles on a Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Buffalo from Missoula Intl. (MSO)?
From Missoula Intl. (MSO), you can fly into Buffalo Niagara Intl. (BUF) to reach Buffalo. Some flights may connect through major hubs like Denver Intl. (DEN), Salt Lake City Intl. (SLC), Minneapolis - St. Paul Intl. (MSP) before reaching Buffalo. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) at the last minute?
Typically, booking a last minute flight from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight and hotel package?
Securing a Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) Buffalo Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
If you booked your Missoula, MT (MSO-Missoula Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Missoula Intl.
Destination airport
Buffalo Niagara Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, United
Roundtrip price
$358
Distance
1735 mi

Book with confidence

Missoula to Buffalo Flights

The cheapest times to fly from Missoula to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Missoula to Buffalo are during the month of November. You can find some of the cheapest flights from Missoula to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Missoula to Buffalo

Sunday is one of the best days to book for cheap flights from Missoula to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Missoula to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Missoula to Buffalo in 2026. You can also book with separate airlines for your outbound and return journeys, from $203 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Missoula to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Missoula to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Missoula to Buffalo Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

Explore a world of travel with Expedia