$167 Cheap Flights from Myrtle Beach (MYR) to Buffalo (BUF)
Popular airlines from Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF)
American AirlinesAmerican Airlines
DeltaDelta
UnitedUnited
Southwest AirlinesSouthwest Airlines
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Cheap Flights from Myrtle Beach to Buffalo (MYR-BUF)
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North Myrtle Beach (MYR) to Buffalo (BUF) at a glance
Travel between North Myrtle Beach (MYR) and Buffalo (BUF) with a selection of airlines servicing this domestic short-haul route. Explore various options from both full-service and budget carriers to identify an itinerary that aligns with your budget and schedule. As you plan your visit to Buffalo's iconic attractions and neighborhoods, gather essential information about flights from Myrtle Beach International Airport to Buffalo Niagara International Airport, ensuring a smooth journey for your next adventure.
- Fastest (typical) flight duration: around 3 hours in-flight, plus roughly 1h 15m layover with one stop
- Route distance: roughly 600 miles (970 km)
- Flights per week: around 11 departures on average
- Typical fares (one-way): economy tickets often range from $110–$380, depending on seasonality and how far ahead you book
Flights from Myrtle Beach International Airport (MYR) to Buffalo Niagara International Airport (BUF)
According to recent traveler preferences, the top airlines from North Myrtle Beach to Buffalo are often selected for their one-stop service, featuring popular layovers at Charlotte-Douglas International Airport (CLT, about 1-hour layover), Baltimore Washington International Thurgood Marshall Airport (BWI, approximately 1 hour and 15 minutes), and Hartsfield-Jackson Atlanta International Airport (ATL, around 1 hour and 30 minutes). These options allow you to customize your journey based on price, total travel time, and cabin class, ensuring you find the ideal itinerary for your needs.
- American Airlines: This full-service airline provides one-stop travel options, with one-way fares generally priced between $110 and $380. It represents about 46% of departures along this route, featuring an in-flight duration of 3 hours and a total travel time of approximately 4 hours and 15 minutes, including layover time.
- Delta: As a full-service carrier, Delta also offers one-stop flight services, with typical one-way fares ranging from $110 to $380. It comprises roughly 27% of the departures for this route, boasting a flight time of 3 hours and an overall journey duration of about 4 hours and 15 minutes, factoring in the layover.
- Southwest Airlines: This low-cost airline features one-stop service, with one-way ticket prices usually varying from $125 to $380. Southwest accounts for approximately 23% of the departures on this route, with an in-flight time of 3 hours and a total journey time of around 4 hours and 15 minutes, including any layover.
- United: As a full-service airline providing one-stop services, United's one-way fares typically range from $130 to $325. It represents about 4% of the departures on this route, offering a flight duration of 3 hours and a total travel time of approximately 4 hours and 15 minutes, including layover time.
Travelers have the option to enhance their journey from North Myrtle Beach to Buffalo by upgrading their flight. Delta features both first class and premium economy class, while American Airlines provides first-class service.
Best time to fly from North Myrtle Beach (MYR) to Buffalo (BUF)
The most popular months for travelers flying from North Myrtle Beach to Buffalo are April, July, and August, when peak temperatures in Buffalo reach up to 72°F in July. If you prefer quieter travel, consider October, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 53.2°F. For better deals, September usually offers the lowest average one-way fare around $175. Flight availability peaks in August, with approximately 14 flights per week, making it easier to find convenient departure times. January, March, and December have the fewest flights, with approximately 8 flights per week.
- Cheapest time to fly: September usually offers good deals with average one-way fare around $175, roughly 17% cheaper than the yearly average.
- More budget-friendly months to fly: August, June, and July typically offer average one-way fares of around $186.
- Most flight options: August has the highest number of flights from North Myrtle Beach to Buffalo, with approximately 14 flights per week, giving you more flexibility in scheduling your trip.
| Month | Temperature | Demand | Weekly Flights | Average one-way Fare |
| January | 25.5°F (-3.6°C) | Low | 8 | $224 |
| February | 26.1°F (-3.3°C) | Average | 10 | $246 |
| March | 34.3°F (1.3°C) | Average | 8 | $234 |
| April | 45.0°F (7.2°C) | High | 13 | $237 |
| May | 57.7°F (14.3°C) | Average | 11 | $225 |
| June | 66.0°F (18.9°C) | Average | 11 | $186 |
| July | 72.0°F (22.2°C) | High | 13 | $190 |
| August | 70.7°F (21.5°C) | High | 14 | $181 |
| September | 64.6°F (18.1°C) | Average | 9 | $175 |
| October | 53.2°F (11.8°C) | Low | 9 | $199 |
| November | 41.4°F (5.2°C) | Average | 12 | $206 |
| December | 33.1°F (0.6°C) | Low | 8 | $236 |
*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.
Alternative route from North Myrtle Beach (MYR) to Buffalo (BUF)
- North Myrtle Beach to Rochester (MYR-ROC): Greater Rochester International Airport (ROC) is located approximately 56 miles from Buffalo Niagara International Airport (BUF). One-way economy prices for this journey generally fall between $55 and $380, influenced by the time of year and advance booking. Travelers can choose from both non-stop and one-stop flights, with common layover locations being Charlotte-Douglas International Airport (CLT) and Baltimore Washington International Thurgood Marshall Airport (BWI). Major airlines operating this route include American Airlines and budget-friendly Southwest Airlines. Additionally, first-class service is offered on this route.
How to find the best prices for flights from North Myrtle Beach (MYR) to Buffalo (BUF)
Getting some of the best deals on flights from North Myrtle Beach to Buffalo is all about timing and flexibility. Here are some key tips to help you save:
- Best times to book and fly: cheaper fares are usually found when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Departures in the afternoon (12pm-6pm) tend to be less expensive and are also the most popular times for flights. Additionally, flying on Wednesday generally offers lower prices, while Friday remains the most sought-after travel day.
- Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
- Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
- Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
- Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
- Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.
*Members only. Savings vary and are not available on all bundles. Select hotels.
Arriving at Buffalo Niagara International Airport from Myrtle Beach International Airport
Buffalo welcomes travelers from North Myrtle Beach with a range of transport options based on price, convenience, and proximity. Here's how to reach Buffalo efficiently:
- Hotel transfer: Transfers offer a convenient way to reach your hotel in Buffalo, with private rides that can be arranged in advance.
- Car rental: Renting a car from Buffalo Niagara International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Buffalo Niagara International Airport on Expedia.
- Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
- Public transportation: From Buffalo Niagara International Airport, Buffalo-Depew Station, a train station, is located about 2.6 miles away by car, while University Station, a metro station, is situated approximately 6.5 miles from the airport, also reachable by car.
Myrtle Beach to Buffalo Flights
The cheapest times to fly from Myrtle Beach to Buffalo
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Buffalo are during the month of December. You can find some of the cheapest flights from Myrtle Beach to Buffalo with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Myrtle Beach to Buffalo
Sunday is one of the best days to book for cheap flights from Myrtle Beach to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Myrtle Beach to Buffalo
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Buffalo in 2026. You can also book with separate airlines for your outbound and return journeys, from $167 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
Frequently Asked Questions
How much does a flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) cost?
You can find cheap one-way flights from $167 and cheap return flights $333 Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) with Expedia. One-way flights usually range from $148 to $1282, and return flights typically cost between $315 and $973. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) ticket fares go up or down.
*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
March is the cheapest month to fly from Myrtle Beach to Buffalo, with average return fares around $256. This price is about 23% lower than the average throughout the year, as demand tends to dip after the winter months. Other affordable months for this route include May and September.
*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Enter MYR to BUF and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
To find a cheap flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
For flights from Myrtle Beach, SC (MYR) to Buffalo, NY (BUF), March and September are your best options. Average return flight prices are around $256, making it an affordable choice. March is great for early spring travel, while September allows you to enjoy the beautiful fall scenery in New York.
*Prices based on flights available on Expedia in the last year.
What is the earliest flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The earliest flight from Myrtle Beach International Airport (MYR) to Buffalo Niagara International Airport (BUF) typically departs at around 5:00 AM, operated by American Airlines. This seasonal service is active in December, allowing you to maximize your time in Buffalo. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The most popular departure times for flights from Myrtle Beach (MYR) to Buffalo (BUF) are in the early afternoon, from 12pm to 3pm. About 28% of passengers prefer this time window. Many major carriers, including American Airlines, Southwest Airlines and Delta Air Lines, offer flights during this window. This timing works well because it allows travelers to enjoy their morning before heading to the airport.
How long does it take to fly from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
A flight from MYR to BUF with a layover takes around 4 hours 30 minutes, with the route covering approximately 639 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
You can fly first class between MYR and BUF. First class cabins are available on:
- Delta Air Lines
- American Airlines
- United Airlines
How do I earn miles on a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight with Expedia?
It's easy to earn miles on a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.
*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Buffalo from MYR (MYR)?
From MYR (MYR), you can fly into Buffalo Niagara Intl. (BUF) to reach Buffalo. Some flights may connect through major hubs like Liberty Intl. (EWR), Charlotte-Douglas Intl. (CLT), Hartsfield-Jackson Atlanta Intl. (ATL) before reaching Buffalo. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) at the last minute?
Typically, booking a last minute flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight and hotel package?
Securing a Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) Buffalo Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
If you booked your Myrtle Beach, SC (MYR-Myrtle Beach Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.
Travel information
Origin airport | Myrtle Beach Intl. Airport |
|---|---|
Destination airport | Buffalo Niagara Intl. Airport |
Distance | 639 miles away |
Airlines serving | American Airlines, Delta, United, Southwest Airlines |
Popular airline | American Airlines |
Roundtrip price | $333 |