$87 Cheap Flights from Myrtle Beach (MYR) to Indianapolis (IND)

View $87 flight on Sat, Nov 1, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND)

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Cheap Flights from Myrtle Beach to Indianapolis (MYR-IND)

Prices were available within the past 7 days and start at $87 for one-way flights and $168 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Mon, Nov 3 - Tue, Nov 11
MYR
Myrtle Beach
IND
Indianapolis
$168 Roundtrip, found 4 hours ago
$168
Roundtrip
found 4 hours ago
Select Spirit Airlines flight, departing Mon, Nov 3 from Myrtle Beach to Indianapolis, returning Tue, Nov 11, priced at $168 found 4 hours ago
Spirit Airlines
Sat, Nov 1 - Sun, Nov 16
MYR
Myrtle Beach
IND
Indianapolis
$174 Roundtrip, just found
$174
Roundtrip
just found
Select Spirit Airlines flight, departing Sat, Nov 1 from Myrtle Beach to Indianapolis, returning Sun, Nov 16, priced at $174 just found
Spirit Airlines
Sat, Nov 1 - Fri, Nov 7
MYR
Myrtle Beach
IND
Indianapolis
$193 Roundtrip, found 3 hours ago
$193
Roundtrip
found 3 hours ago
Select Spirit Airlines flight, departing Sat, Nov 1 from Myrtle Beach to Indianapolis, returning Fri, Nov 7, priced at $193 found 3 hours ago
American Airlines
Fri, Oct 31 - Sat, Nov 8
MYR
Myrtle Beach
IND
Indianapolis
$206 Roundtrip, found 3 hours ago
$206
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Oct 31 from Myrtle Beach to Indianapolis, returning Sat, Nov 8, priced at $206 found 3 hours ago
Southwest Airlines
Fri, Oct 31 - Sat, Nov 8
MYR
Myrtle Beach
IND
Indianapolis
$211 Roundtrip, found 3 hours ago
$211
Roundtrip
found 3 hours ago
Select Southwest Airlines flight, departing Fri, Oct 31 from Myrtle Beach to Indianapolis, returning Sat, Nov 8, priced at $211 found 3 hours ago
Spirit Airlines
Sat, Jan 10 - Sun, Jan 11
MYR
Myrtle Beach
IND
Indianapolis
$212 Roundtrip, found 19 hours ago
$212
Roundtrip
found 19 hours ago
Select Spirit Airlines flight, departing Sat, Jan 10 from Myrtle Beach to Indianapolis, returning Sun, Jan 11, priced at $212 found 19 hours ago
Spirit Airlines
Thu, Nov 20 - Mon, Nov 24
MYR
Myrtle Beach
IND
Indianapolis
$225 Roundtrip, found 2 hours ago
$225
Roundtrip
found 2 hours ago
Select Spirit Airlines flight, departing Thu, Nov 20 from Myrtle Beach to Indianapolis, returning Mon, Nov 24, priced at $225 found 2 hours ago
Spirit Airlines
Wed, Oct 22 - Mon, Oct 27
MYR
Myrtle Beach
IND
Indianapolis
$225 Roundtrip, found 1 day ago
$225
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Wed, Oct 22 from Myrtle Beach to Indianapolis, returning Mon, Oct 27, priced at $225 found 1 day ago
United
Fri, Oct 31 - Sat, Nov 8
MYR
Myrtle Beach
IND
Indianapolis
$237 Roundtrip, found 3 hours ago
$237
Roundtrip
found 3 hours ago
Select United flight, departing Fri, Oct 31 from Myrtle Beach to Indianapolis, returning Sat, Nov 8, priced at $237 found 3 hours ago
Delta
Thu, Dec 25 - Wed, Dec 31
MYR
Myrtle Beach
IND
Indianapolis
$237 Roundtrip, found 23 hours ago
$237
Roundtrip
found 23 hours ago
Select Delta flight, departing Thu, Dec 25 from Myrtle Beach to Indianapolis, returning Wed, Dec 31, priced at $237 found 23 hours ago

Find the cheapest month to fly from Myrtle Beach (MYR) to Indianapolis (IND)

May is typically the cheapest month to fly

From $148 - $346 per traveler.

Alternative airports near Indianapolis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Indianapolis Intl. IND. Cheapest and Closest option available. Average driving time to city center is 19 minutes. Flights from $340
IND
Indianapolis Intl.
CheapestClosest
Average driving time to city center19 min
Flights from $340

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND) cost?
Get a cheap one-way flight from $87 or cheap return flight from $168 from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND)?
November is the cheapest month to fly from MYR to IND. Timing your trip outside of the busy season is often the key to finding better deals on flights.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND)?
To find the cheapest airline that'll fly you from MYR to IND, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND)?
You'll need to take a flight with a layover if you're traveling from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from MYR to IND?
You'll usually find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND)?
Select a flight from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND) that takes off before 3 PM to reduce the risk of cancellations and delays. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND) last-minute?
Holding off until right before your break to book your flight from MYR to IND generally means paying more. Although you may find some last-minute deals, there's no guarantee. Keep your travel schedule open for the best chance of getting a bargain.
Is it cheaper to book a MYR to IND flight and hotel package?
Securing a MYR to IND flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Select from our wide range of accommodations and then add flights, activities and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Indianapolis Intl. Airport (IND)?
If you booked your MYR to IND flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Indianapolis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, Spirit Airlines, United
Roundtrip price
$168
Distance
583 mi

Book with confidence

Myrtle Beach to Indianapolis Flights

The cheapest times to fly from Myrtle Beach to Indianapolis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Indianapolis are during the month of November. You can find some of the cheapest flights from Myrtle Beach to Indianapolis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Indianapolis

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Indianapolis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Indianapolis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Indianapolis in 2025. You can also book with separate airlines for your outbound and return journeys, from $87 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Indianapolis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Indianapolis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Indianapolis Flights

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*Available to One Key members.