$620 Cheap Flights from Myrtle Beach (MYR) to Muscle Shoals (MSL)

View $620 flight on Mon, Sep 29, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Muscle Shoals, AL (MSL-Northwest Alabama Regional)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Myrtle Beach to Muscle Shoals (MYR-MSL)

Prices were available within the past 7 days and start at $620 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL) cost?
Grab a cheap one-way flight from $620 or cheap return flight from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL)?
The cheapest month to fly from MYR to MSL is , when demand is low. Off-peak months are usually when better flight deals are available between these airports.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL)?
To find the cheapest airline that'll fly you from MYR to MSL, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL)?
There aren't any daily nonstop flights from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be cruising above the clouds in no time at all.
What day of the week has the most flights from MYR to MSL?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary depending on various factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL)?
Select a flight from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL) last-minute?
Booking your ticket from MYR to MSL right before your getaway is generally more expensive. However, if you're flexible with your itinerary, you could land a cheap last-minute fare.
Is it cheaper to book a MYR to MSL flight and hotel package?
You'll generally save money by securing a MYR to MSL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one convenient place. After selecting your preferred accommodations and flights, you can add extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Northwest Alabama Regional Airport (MSL)?
You can usually cancel or reschedule your MYR to MSL flight. However, for bookings made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Northwest Alabama Regional
Distance
502 mi

Book with confidence

Book with confidence

Myrtle Beach to Muscle Shoals Flights

The cheapest times to fly from Myrtle Beach to Muscle Shoals

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Muscle Shoals are during the month of . You can find some of the cheapest flights from Myrtle Beach to Muscle Shoals with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Muscle Shoals

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Muscle Shoals: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Muscle Shoals

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Muscle Shoals in 2025. You can also book with separate airlines for your outbound and return journeys, from $620 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Muscle Shoals flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Muscle Shoals airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Muscle Shoals Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.