$305 Cheap Flights from Panama City (PTY) to Buffalo (BUF)

View $305 flight on Sat, Dec 6, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF)

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Cheap Flights from Panama City to Buffalo (PTY-BUF)

Prices were available within the past 7 days and start at $305 for one-way flights and $535 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Nov 12 - Sun, Nov 16
PTY
Panama City
BUF
Buffalo
$535 Roundtrip, found 2 days ago
$535
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Nov 12 from Panama City to Buffalo, returning Sun, Nov 16, priced at $535 found 2 days ago
Delta
Wed, Dec 17 - Fri, Jan 16
PTY
Panama City
BUF
Buffalo
$536 Roundtrip, found 6 days ago
$536
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Dec 17 from Panama City to Buffalo, returning Fri, Jan 16, priced at $536 found 6 days ago
United
Fri, Dec 26 - Thu, Jan 1
PTY
Panama City
BUF
Buffalo
$538 Roundtrip, found 14 hours ago
$538
Roundtrip
found 14 hours ago
Select United flight, departing Fri, Dec 26 from Panama City to Buffalo, returning Thu, Jan 1, priced at $538 found 14 hours ago
United
Fri, Nov 21 - Fri, Nov 28
PTY
Panama City
BUF
Buffalo
$538 Roundtrip, found 2 days ago
$538
Roundtrip
found 2 days ago
Select United flight, departing Fri, Nov 21 from Panama City to Buffalo, returning Fri, Nov 28, priced at $538 found 2 days ago
United
Fri, May 22 - Sun, May 31
PTY
Panama City
BUF
Buffalo
$541 Roundtrip, found 4 days ago
$541
Roundtrip
found 4 days ago
Select United flight, departing Fri, May 22 from Panama City to Buffalo, returning Sun, May 31, priced at $541 found 4 days ago
American Airlines
Fri, Dec 26 - Thu, Jan 1
PTY
Panama City
BUF
Buffalo
$543 Roundtrip, found 14 hours ago
$543
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, Dec 26 from Panama City to Buffalo, returning Thu, Jan 1, priced at $543 found 14 hours ago
Delta
Wed, Nov 12 - Sun, Nov 16
PTY
Panama City
BUF
Buffalo
$544 Roundtrip, found 2 days ago
$544
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Nov 12 from Panama City to Buffalo, returning Sun, Nov 16, priced at $544 found 2 days ago
Delta
Sun, Dec 28 - Fri, Jan 2
PTY
Panama City
BUF
Buffalo
$544 Roundtrip, found 18 hours ago
$544
Roundtrip
found 18 hours ago
Select Delta flight, departing Sun, Dec 28 from Panama City to Buffalo, returning Fri, Jan 2, priced at $544 found 18 hours ago
avianca
Fri, Nov 21 - Fri, Nov 28
PTY
Panama City
BUF
Buffalo
$572 Roundtrip, found 2 days ago
$572
Roundtrip
found 2 days ago
Select avianca flight, departing Fri, Nov 21 from Panama City to Buffalo, returning Fri, Nov 28, priced at $572 found 2 days ago
Copa
Wed, Dec 17 - Fri, Jan 16
PTY
Panama City
BUF
Buffalo
$1,278 Roundtrip, found 6 days ago
$1,278
Roundtrip
found 6 days ago
Select Copa flight, departing Wed, Dec 17 from Panama City to Buffalo, returning Fri, Jan 16, priced at $1,278 found 6 days ago

Alternative airports near Buffalo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Buffalo Niagara Intl. BUF. Cheapest and Closest option available. Average driving time to city center is 16 minutes. Flights from $544
BUF
Buffalo Niagara Intl.
CheapestClosest
Average driving time to city center16 min
Flights from $544

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF) cost?
Grab a cheap one-way flight from $305 or cheap return flight from $535 from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF)?
Flying in November is a good way to save, as it's the cheapest month for flights between PTY and BUF. You'll often find the lowest fares during off-peak months.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest PTY to BUF flight.
How many flights per day from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF)?
Direct flights from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from PTY to BUF?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF)?
Select a flight from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF) last-minute?
Last-minute fares from PTY to BUF are usually more expensive. To secure the cheapest rates, start looking for flights early. That being said, if you're flexible with your travel dates, you may land a cheap ticket right before you leave.
Is it cheaper to book a PTY to BUF flight and hotel package?
Securing a PTY to BUF flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Select from our wide range of hotels and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Buffalo Niagara Intl. Airport (BUF)?
If you reserved your PTY to BUF flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

Travel information

Origin airport
Tocumen Intl.
Destination airport
Buffalo Niagara Intl.
Roundtrip price
$534
Distance
2340 mi

Book with confidence

Panama City to Buffalo Flights

The cheapest times to fly from Panama City to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Buffalo are during the month of November. You can find some of the cheapest flights from Panama City to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Buffalo

Sunday is one of the best days to book for cheap flights from Panama City to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Buffalo in 2025. You can also book with separate airlines for your outbound and return journeys, from $305 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Panama City to Buffalo Flights

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*Available to One Key members.