$326 Cheap Flights from Santo Domingo (SDQ) to Key West (EYW)

View $326 flight on Wed, Oct 29, 2025Opens in a new window

Popular airlines from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW)

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Cheap Flights from Santo Domingo to Key West (SDQ-EYW)

Prices were available within the past 7 days and start at $326 for one-way flights and $515 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Oct 29 - Mon, Nov 3
SDQ
Santo Domingo
EYW
Key West
$515 Roundtrip, found 2 days ago
$515
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 29 from Santo Domingo to Key West, returning Mon, Nov 3, priced at $515 found 2 days ago
American Airlines
Wed, Oct 29 - Mon, Nov 3
SDQ
Santo Domingo
EYW
Key West
$521 Roundtrip, found 2 days ago
$521
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 29 from Santo Domingo to Key West, returning Mon, Nov 3, priced at $521 found 2 days ago
American Airlines
Wed, Oct 29 - Mon, Nov 3
SDQ
Santo Domingo
EYW
Key West
$528 Roundtrip, found 2 days ago
$528
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 29 from Santo Domingo to Key West, returning Mon, Nov 3, priced at $528 found 2 days ago
United
Mon, Oct 27 - Mon, Nov 3
SDQ
Santo Domingo
EYW
Key West
$534 Roundtrip, found 4 days ago
$534
Roundtrip
found 4 days ago
Select United flight, departing Mon, Oct 27 from Santo Domingo to Key West, returning Mon, Nov 3, priced at $534 found 4 days ago
United
Sun, Oct 26 - Mon, Nov 3
SDQ
Santo Domingo
EYW
Key West
$558 Roundtrip, found 4 days ago
$558
Roundtrip
found 4 days ago
Select United flight, departing Sun, Oct 26 from Santo Domingo to Key West, returning Mon, Nov 3, priced at $558 found 4 days ago
American Airlines
Wed, Oct 29 - Mon, Nov 3
SDQ
Santo Domingo
EYW
Key West
$565 Roundtrip, found 2 days ago
$565
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 29 from Santo Domingo to Key West, returning Mon, Nov 3, priced at $565 found 2 days ago
American Airlines
Wed, Oct 29 - Mon, Nov 3
SDQ
Santo Domingo
EYW
Key West
$565 Roundtrip, found 2 days ago
$565
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 29 from Santo Domingo to Key West, returning Mon, Nov 3, priced at $565 found 2 days ago
American Airlines
Wed, Oct 29 - Mon, Nov 3
SDQ
Santo Domingo
EYW
Key West
$572 Roundtrip, found 2 days ago
$572
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Oct 29 from Santo Domingo to Key West, returning Mon, Nov 3, priced at $572 found 2 days ago
United
Wed, Oct 29 - Mon, Nov 3
SDQ
Santo Domingo
EYW
Key West
$580 Roundtrip, found 2 days ago
$580
Roundtrip
found 2 days ago
Select United flight, departing Wed, Oct 29 from Santo Domingo to Key West, returning Mon, Nov 3, priced at $580 found 2 days ago
JetBlue Airways
Thu, Oct 30 - Sat, Nov 1
SDQ
Santo Domingo
EYW
Key West
$640 Roundtrip, found 4 days ago
$640
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Thu, Oct 30 from Santo Domingo to Key West, returning Sat, Nov 1, priced at $640 found 4 days ago

Frequently asked questions

How much does a flight from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW) cost?
Get a cheap one-way flight from $326 or cheap return flight from $515 from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW)?
Traveling in October is a great way to save, as it's the cheapest month for flights between SDQ and EYW. You'll often find the lowest fares during the off-season.
What is the cheapest airline that flies from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW)?
To find the cheapest airline that'll fly you from SDQ to EYW, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW)?
Direct flights from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from SDQ to EYW?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary based on a number of factors, such as the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW)?
Choose a flight from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW) last-minute?
Waiting until just before your departure to book your flight from SDQ to EYW often results in higher prices. While you may find some last-minute discounts, they aren't always guaranteed. Allow some flexibility in your schedule to boost your chances of snagging a bargain.
Is it cheaper to book a SDQ to EYW flight and hotel package?
Compared with arranging hotels and flights separately, booking a SDQ to EYW flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one place takes the hassle out of travel planning. Simply secure your flights and select from our wide range of stays, then customize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Las Americas Intl. Airport (SDQ) to Key West Intl. Airport (EYW)?
In most cases, you're able to cancel or reschedule your SDQ to EYW flight. However, additional charges may apply, especially if you booked more than 24 hours ago. Check your itinerary for the airline's fees and guidelines on flight changes, or if you need further details, visit our Customer Service portal.

Travel information

Travel information

Origin airport
Las Americas Intl.
Destination airport
Key West Intl.
Roundtrip price
$514
Distance
883 mi

Book with confidence

Book with confidence

Santo Domingo to Key West Flights

The cheapest times to fly from Santo Domingo to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santo Domingo to Key West are during the month of October. You can find some of the cheapest flights from Santo Domingo to Key West with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santo Domingo to Key West

Sunday is one of the best days to book for cheap flights from Santo Domingo to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santo Domingo to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santo Domingo to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $326 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santo Domingo to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santo Domingo to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Santo Domingo to Key West Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.