$435 Cheap Flights from St. Louis (STL) to Santiago (SCL)

View $435 flight on Wed, Nov 5, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Santiago Intl. Airport (SCL)

Cheap Flights from St. Louis to Santiago (STL-SCL)

Prices were available within the past 7 days and start at $435 for one-way flights and $764 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$764 Roundtrip, just found
$764
Roundtrip
just found
Select American Airlines flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $764 just found
Delta
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$764 Roundtrip, just found
$764
Roundtrip
just found
Select Delta flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $764 just found
United
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$764 Roundtrip, just found
$764
Roundtrip
just found
Select United flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $764 just found
American Airlines
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$769 Roundtrip, just found
$769
Roundtrip
just found
Select American Airlines flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $769 just found
Delta
Wed, Mar 4 - Wed, Mar 18
STL
St. Louis
SCL
Santiago
$771 Roundtrip, found 22 hours ago
$771
Roundtrip
found 22 hours ago
Select Delta flight, departing Wed, Mar 4 from St. Louis to Santiago, returning Wed, Mar 18, priced at $771 found 22 hours ago
American Airlines
Wed, Dec 10 - Wed, Dec 17
STL
St. Louis
SCL
Santiago
$774 Roundtrip, found 2 days ago
$774
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Dec 10 from St. Louis to Santiago, returning Wed, Dec 17, priced at $774 found 2 days ago
Delta
Mon, Oct 13 - Mon, Oct 20
STL
St. Louis
SCL
Santiago
$776 Roundtrip, found 3 days ago
$776
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Oct 13 from St. Louis to Santiago, returning Mon, Oct 20, priced at $776 found 3 days ago
American Airlines
Tue, Feb 10 - Wed, Feb 18
STL
St. Louis
SCL
Santiago
$776 Roundtrip, found 18 hours ago
$776
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Tue, Feb 10 from St. Louis to Santiago, returning Wed, Feb 18, priced at $776 found 18 hours ago
LATAM Airlines Group
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$784 Roundtrip, just found
$784
Roundtrip
just found
Select LATAM Airlines Group flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $784 just found
Air Canada
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$853 Roundtrip, just found
$853
Roundtrip
just found
Select Air Canada flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $853 just found

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $804
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $804

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL) cost?
Snag a cheap one-way flight from $435 or cheap return flight from $764 from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
November is the least expensive month to fly from STL to SCL. Traveling during an off-peak travel window is often the key to better flight prices.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest STL to SCL flight.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
There are no daily direct flights departing from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way in no time at all.
What day of the week has the most flights from STL to SCL?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on a range of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
To touch down at Arturo Merino Benitez Airport (SCL) on schedule, pick a flight that takes off from Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your flight from STL to SCL right before your journey is usually more expensive. However, if you're flexible with your schedule, you could score a cheap last-minute fare.
Is it cheaper to book a STL to SCL flight and hotel package?
You'll generally save money by securing a STL to SCL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one convenient place. After selecting your preferred accommodations and flights, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
You can usually cancel or reschedule your STL to SCL flight. However, if it's been more than 24 hours since booking, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, United, avianca
Roundtrip price
$764
Distance
5139 mi

Book with confidence

Book with confidence

St. Louis to Santiago Flights

The cheapest times to fly from St. Louis to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Santiago are during the month of November. You can find some of the cheapest flights from St. Louis to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Santiago

Sunday is one of the best days to book for cheap flights from St. Louis to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $435 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Santiago Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.