$126 Cheap Flights from Knoxville (TYS) to Buffalo (BUF)

View $126 flight on Tue, Dec 2, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF)

Cheap Flights from Knoxville to Buffalo (TYS-BUF)

Prices were available within the past 7 days and start at $126 for one-way flights and $221 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Dec 9 - Wed, Dec 17
TYS
Knoxville
BUF
Buffalo
$221 Roundtrip, found 6 days ago
$221
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 9 from Knoxville to Buffalo, returning Wed, Dec 17, priced at $221 found 6 days ago
Delta
Tue, Jan 6 - Sat, Jan 24
TYS
Knoxville
BUF
Buffalo
$221 Roundtrip, found 6 days ago
$221
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Jan 6 from Knoxville to Buffalo, returning Sat, Jan 24, priced at $221 found 6 days ago
American Airlines
Tue, Dec 9 - Wed, Dec 17
TYS
Knoxville
BUF
Buffalo
$221 Roundtrip, found 6 days ago
$221
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Dec 9 from Knoxville to Buffalo, returning Wed, Dec 17, priced at $221 found 6 days ago
Delta
Mon, Jan 5 - Sat, Jan 24
TYS
Knoxville
BUF
Buffalo
$236 Roundtrip, found 6 days ago
$236
Roundtrip
found 6 days ago
Select Delta flight, departing Mon, Jan 5 from Knoxville to Buffalo, returning Sat, Jan 24, priced at $236 found 6 days ago
American Airlines
Wed, Jan 7 - Thu, Jan 8
TYS
Knoxville
BUF
Buffalo
$238 Roundtrip, found 6 days ago
$238
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Jan 7 from Knoxville to Buffalo, returning Thu, Jan 8, priced at $238 found 6 days ago
American Airlines
Thu, Dec 18 - Tue, Jan 6
TYS
Knoxville
BUF
Buffalo
$239 Roundtrip, found 6 days ago
$239
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Dec 18 from Knoxville to Buffalo, returning Tue, Jan 6, priced at $239 found 6 days ago
Delta
Tue, Jan 6 - Fri, Jan 23
TYS
Knoxville
BUF
Buffalo
$245 Roundtrip, found 6 days ago
$245
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Jan 6 from Knoxville to Buffalo, returning Fri, Jan 23, priced at $245 found 6 days ago
American Airlines
Tue, Dec 2 - Tue, Dec 9
TYS
Knoxville
BUF
Buffalo
$251 Roundtrip, found 5 hours ago
$251
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Tue, Dec 2 from Knoxville to Buffalo, returning Tue, Dec 9, priced at $251 found 5 hours ago
United
Wed, Jan 7 - Thu, Jan 8
TYS
Knoxville
BUF
Buffalo
$256 Roundtrip, found 6 days ago
$256
Roundtrip
found 6 days ago
Select United flight, departing Wed, Jan 7 from Knoxville to Buffalo, returning Thu, Jan 8, priced at $256 found 6 days ago
Southwest Airlines
Tue, Mar 24 - Sat, Mar 28
TYS
Knoxville
BUF
Buffalo
$294 Roundtrip, found 6 days ago
$294
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Tue, Mar 24 from Knoxville to Buffalo, returning Sat, Mar 28, priced at $294 found 6 days ago

Find the cheapest month to fly from Knoxville (TYS) to Buffalo (BUF)

May is typically the cheapest month to fly

From $198 - $471 per traveler.

Alternative airports near Buffalo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Buffalo Niagara Intl. BUF. Cheapest and Closest option available. Average driving time to city center is 16 minutes. Flights from $265
BUF
Buffalo Niagara Intl.
CheapestClosest
Average driving time to city center16 min
Flights from $265
Flights from Knoxville (TYS) to Buffalo (BUF)
Origin airport
McGhee Tyson
Destination airport
Buffalo Niagara Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$220
Distance
566 mi

Knoxville to Buffalo Flights

The cheapest times to fly from Knoxville to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Buffalo are during the month of December. You can find some of the cheapest flights from Knoxville to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Buffalo

Sunday is one of the best days to book for cheap flights from Knoxville to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Buffalo in 2025. You can also book with separate airlines for your outbound and return journeys, from $126 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF) cost?
Snag a cheap one-way flight from $126 or cheap return flight from $221 from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF)?
The cheapest month to fly from TYS to BUF is December, when demand is low. Off-peak season is often when airlines offer lower prices between these airports.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF)?
To find the cheapest airline that'll fly you from TYS to BUF, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF)?
Direct flights from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TYS to BUF?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF)?
Opt for a flight from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF) that takes off before 3 PM to reduce the likelihood of delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF) last-minute?
Booking your flight from TYS to BUF shortly before your trip is generally more expensive. But if you're flexible with your itinerary, you could grab a cheap last-minute fare.
Is it cheaper to book a TYS to BUF flight and hotel package?
Booking a TYS to BUF flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Select from our impressive range of hotels and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Buffalo Niagara Intl. Airport (BUF)?
If you booked your TYS to BUF flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.