Santa Cruz Island Luxury Vacations

Book a Luxury Hotel + Flight or Car together to unlock savings

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Top Luxury vacation packages in Santa Cruz Island

Price found within the past 48 hours. Click for updated prices.
Blu Galapagos Sustainable Waterfront Lodge
Finch Bay Galapagos Hotel
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3 Night Luxury vacations in Santa Cruz Island

Price found within the past 48 hours. Click for updated prices.
Blu Galapagos Sustainable Waterfront Lodge
Finch Bay Galapagos Hotel
Don't see what you're looking for?
See all available trips from Columbus to Santa Cruz Island
View all trips

4 Night Luxury vacations in Santa Cruz Island

Price found within the past 48 hours. Click for updated prices.
Blu Galapagos Sustainable Waterfront Lodge
Finch Bay Galapagos Hotel
Don't see what you're looking for?
See all available trips from Columbus to Santa Cruz Island
View all trips

All you need to know about luxury vacations in Santa Cruz Island

What can I expect from a luxury Santa Cruz Island vacation?

Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury Santa Cruz Island vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views. 

How can I find all-inclusive luxury vacation packages in Santa Cruz Island?

By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5* filter to find truly sensational stays. You barely need to lift a finger. 

Can I book a cheap Santa Cruz Island luxury vacation?

Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $544. Prices and availability are subject to change. Additional terms may apply.

How can I book a luxury family vacation in Santa Cruz Island?

Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi. 

Can I book a package in Santa Cruz Island with a luxury vacation home?

A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package.   

How can I find the best luxury vacation deals in Santa Cruz Island?

Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months.

Can I book a luxury holiday in Santa Cruz Island with free cancellation and/or flexible dates?

Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan. 

Why should I book my luxury trip to Santa Cruz Island with Expedia?

A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind.

Top Luxury Santa Cruz Island Hotels

Hotel Ninfa

Hotel Ninfa

3.5 out of 5
Settlers and Thomas de Berlanga, Puerto Ayora, Galapagos
  • 29 min walk from Tortuga Bay Beach
Stay in the lap of luxury at Hotel Ninfa, where you can enjoy amenities like plush bedding, flat-screen TVs, and more. Deluxe amenities at this hotel include ...
8.2/10 Very Good! (209 reviews)
"Great"

Reviewed on Sep 22, 2025

Hotel Ninfa
Blu Galapagos Sustainable Waterfront Lodge

Blu Galapagos Sustainable Waterfront Lodge

4 out of 5
Ave. Charles Darwin S/n Y Piquero, Puerto Ayora, Galapagos
  • 5 min drive from Tortuga Bay Beach
Be treated to luxurious accommodations at Blu Galapagos Sustainable Waterfront Lodge, where you can enjoy amenities like Champagne service, designer toiletries, ...
8.6/10 Excellent! (117 reviews)
"If you stay here make sure you get a receipt when you pay your room tab. When I got home I received a bill for what I paid for already. I was told everything was good when I checked out. A lady the day before also had trouble with her room tab."

Reviewed on Sep 24, 2025

Blu Galapagos Sustainable Waterfront Lodge
Finch Bay Galapagos Hotel

Finch Bay Galapagos Hotel

4.5 out of 5
Barrio Punta Estrada, Puerto Ayora, Galapagos
  • 27 min walk from Tortuga Bay Beach
Finch Bay Galapagos Hotel is a Puerto Ayora luxury 4.5-star beach property where you can treat yourself to Champagne service, pillowtop beds, and more. Deluxe ...
9.2/10 Wonderful! (87 reviews)
"Beautiful resort, impeccably clean, very kind and enthusiastic staff. Delicious restaurant. 5 stars all around, we will definitely return!"

Reviewed on Dec 31, 2024

Finch Bay Galapagos Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.