Title: Santa Cruz Island Vacation Rentals from $76: Search Short-Term Rentals | Expedia.com [Santa Cruz Island Travel Guide](https://expedia.com/Santa-Cruz-Island.dx6053670)[Hotels in Santa Cruz Island](https://expedia.com/Santa-Cruz-Island-Hotels.d6053670.Travel-Guide-Hotels)[Flights to Santa Cruz Island](https://expedia.com/Cheap-Flights-To-Santa-Cruz-Island.d6053670.Travel-Guide-Flights)[Things to do in Santa Cruz Island](https://expedia.com/Things-To-Do-In-Santa-Cruz-Island.d6053670.Travel-Guide-Activities)[Car Rentals in Santa Cruz Island](https://expedia.com/Car-Rentals-In-Santa-Cruz-Island.d6053670.Car-Rental-Guide)[Santa Cruz Island Vacation Packages](https://expedia.com/Santa-Cruz-Island.d6053670.Destination-Travel-Guides) ![Galapagos Marine Iguana walking and swimming on Tortuga bay. Marine iguanas on beach on Santa Cruz Island, Galapagos Islands. Animals, wildlife and amazing nature in Ecuador, South America](https://images.trvl-media.com/place/6053670/54bcca80-11e8-424a-9353-2c1a8014c5d5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6053670/54bcca80-11e8-424a-9353-2c1a8014c5d5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates In two weeks [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6053670&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 15 - May 17](https://www.expedia.com/Hotel-Search?regionId=6053670&startDate=2026-05-15&endDate=2026-05-17&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jun 12 - Jun 14](https://www.expedia.com/Hotel-Search?regionId=6053670&startDate=2026-06-12&endDate=2026-06-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jul 10 - Jul 12](https://www.expedia.com/Hotel-Search?regionId=6053670&startDate=2026-07-10&endDate=2026-07-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Cruz Island vacation rentals ![Family Duplex, 2 Bedrooms, Private Bathroom, Garden View (Courtyard ) | Terrace/patio](https://images.trvl-media.com/lodging/17000000/16790000/16786900/16786878/ffb9bce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/17000000/16790000/16786900/16786878/392aa62b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Ensuite (One bedroom King) | Premium bedding, pillowtop beds, in-room safe, individually decorated](https://images.trvl-media.com/lodging/17000000/16790000/16786900/16786878/34c553bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/17000000/16790000/16786900/16786878/aabb8b8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Torre Mar Galapagos Boutique Suites [](https://www.expedia.com/Puerto-Ayora-Hotels-Torre-Mar-Galapagos-Boutique-Suites.h16786878.Hotel-Information) Puerto Ayora 9.2/10 Wonderful (20 reviews) "Very nice suite, clean, quiet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Masoud $114 nightly $114 total Mar 28 - Mar 29 [](https://www.expedia.com/Puerto-Ayora-Hotels-Torre-Mar-Galapagos-Boutique-Suites.h16786878.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34940000/34937800/34937768/9468ea94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Quadruple Room, 1 Bedroom | 1 bedroom, down comforters, individually furnished, blackout drapes](https://images.trvl-media.com/lodging/35000000/34940000/34937800/34937768/95d1d08f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Quadruple Room, 1 Bedroom | Private kitchen | Fridge, oven, rice cooker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/35000000/34940000/34937800/34937768/7ebdf614.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/35000000/34940000/34937800/34937768/e9355473.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Suites [](https://www.expedia.com/Puerto-Ayora-Hotels-Suites.h34937768.Hotel-Information) Puerto Ayora 9.4/10 Exceptional (24 reviews) "Check was early and friendly staff Room was super clean and comfortable" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Judy $92 nightly $92 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-Suites.h34937768.Hotel-Information) ![Luxury Apartment, Balcony | Living area | LCD TV, Netflix, pay movies, streaming services](https://images.trvl-media.com/lodging/107000000/106890000/106882100/106882041/39eae50b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Apartment, Balcony | Balcony](https://images.trvl-media.com/lodging/107000000/106890000/106882100/106882041/992ac688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, Balcony, City View | Balcony](https://images.trvl-media.com/lodging/107000000/106890000/106882100/106882041/5efe3e57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Apartment, Balcony | Living area | LCD TV, Netflix, pay movies, streaming services](https://images.trvl-media.com/lodging/107000000/106890000/106882100/106882041/7209e130.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galapagos Coliving Ecuador Casa Tuna [](https://www.expedia.com/Puerto-Ayora-Hotels-Galapagos-Coliving-Ecuador-Casa-Tuna.h106882041.Hotel-Information) Puerto Ayora [](https://www.expedia.com/Puerto-Ayora-Hotels-Galapagos-Coliving-Ecuador-Casa-Tuna.h106882041.Hotel-Information) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102790000/102780600/102780548/a58537c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/103000000/102790000/102780600/102780548/b8157967.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/103000000/102790000/102780600/102780548/d98281b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/103000000/102790000/102780600/102780548/d3c64b45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Queen Bedroom Suite ON THE Second High Floor AT Ariana\`s Galapagos Hostal [](https://www.expedia.com/Puerto-Ayora-Hotels-Queen-Bedroom-Suite-ON-THE-Second-High-Floor-AT-Arianas-Galapagos-Hostal.h102780548.Hotel-Information) Puerto Ayora $69 nightly $76 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-Queen-Bedroom-Suite-ON-THE-Second-High-Floor-AT-Arianas-Galapagos-Hostal.h102780548.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100180000/100177100/100177018/e27d3e6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100180000/100177100/100177018/41f41cf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/101000000/100180000/100177100/100177018/cc3d7388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100180000/100177100/100177018/735d660b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ¡Bienvenido a tu hogar isleño en Galápagos! [](https://www.expedia.com/Puerto-Ayora-Hotels-Bienvenido-A-Tu-Hogar-Isleno-En-Galapagos.h100177018.Hotel-Information) Puerto Ayora $102 nightly $102 total Apr 7 - Apr 8 [](https://www.expedia.com/Puerto-Ayora-Hotels-Bienvenido-A-Tu-Hogar-Isleno-En-Galapagos.h100177018.Hotel-Information) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/95000000/94870000/94862300/94862210/f0249e58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/95000000/94870000/94862300/94862210/2475343d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, coffee/tea maker, toaster, cookware/dishes/utensils](https://images.trvl-media.com/lodging/95000000/94870000/94862300/94862210/6f52aa05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/95000000/94870000/94862300/94862210/f1c0fb19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Vacacional en Puerto Ayora, Santa Cruz, Galápagos [](https://www.expedia.com/Puerto-Ayora-Hotels-Casa-Vacacional-En-Puerto-Ayora.h94862210.Hotel-Information) Puerto Ayora 10/10 Exceptional (1 review) "Nice and beautiful house to stay very impressed " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John $121 nightly $121 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-Casa-Vacacional-En-Puerto-Ayora.h94862210.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/51000000/50890000/50883200/50883187/0d9fc98c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/51000000/50890000/50883200/50883187/0467b406.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/51000000/50890000/50883200/50883187/236b5ac4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, coffee/tea maker, cookware/dishes/utensils, lobster pot](https://images.trvl-media.com/lodging/51000000/50890000/50883200/50883187/80603d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment near the Sea [](https://www.expedia.com/Puerto-Ayora-Hotels-Suites-Cerca-Del-Mar.h50883187.Hotel-Information) PUERTO AYORA SANTA CRUZ GALAPAGOS 8.8/10 Excellent (5 reviews) "Really nice place!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sefora $130 nightly $170 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-Suites-Cerca-Del-Mar.h50883187.Hotel-Information) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59690000/59688700/59688686/82ca6a97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/60000000/59690000/59688700/59688686/4b47b389.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/60000000/59690000/59688700/59688686/c896c6c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/60000000/59690000/59688700/59688686/a7583985.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galarous Island Suite comfortable and cozy [](https://www.expedia.com/Puerto-Ayora-Hotels-Galarous-Servirle-Con-Calidad-Y-Calidez-En-Su-Casa.h59688686.Hotel-Information) Puerto Ayora $49 nightly $49 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-Galarous-Servirle-Con-Calidad-Y-Calidez-En-Su-Casa.h59688686.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103430000/103424700/103424658/784c1849.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103430000/103424700/103424658/98c3994e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103430000/103424700/103424658/6359bb06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/104000000/103430000/103424700/103424658/bea60ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### KING SIZE BED & TWIN SIZE BED WITH PRIVATE BATHROOM ON SECOND FLOOR [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h103424658.Hotel-Information) Puerto Ayora $50 nightly $55 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h103424658.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/31000000/30410000/30400900/30400811/1f94b12a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/31000000/30410000/30400900/30400811/369f220c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Townhome, 1 Bedroom, Non Smoking, City View | Living area](https://images.trvl-media.com/lodging/31000000/30410000/30400900/30400811/50aec426.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/31000000/30410000/30400900/30400811/2ad1a614.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villa Galapagos [](https://www.expedia.com/Puerto-Ayora-Hotels-Villa-Galapagos.h30400811.Hotel-Information) Puerto Ayora 6.0/10 (1 review) "着いて早々にダブルブッキングがわかった。これは施設というよりも、貴社のシステムの問題。前回も宿泊名簿に名前がなかったこともあり、強く改善をもとめる。" ![Japan](https://a.travel-assets.com/egds/marks/flags/jp.svg) アオアシカツオドリ [](https://www.expedia.com/Puerto-Ayora-Hotels-Villa-Galapagos.h30400811.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/103000000/102730000/102721900/102721840/9465b582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/103000000/102730000/102721900/102721840/daa6d638.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/103000000/102730000/102721900/102721840/5328eb63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102730000/102721900/102721840/343f2f1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TWO Bedrooms Apartment ON THE Ground Floor IN Ariana\`s Galapagos Hostal [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h102721840.Hotel-Information) Puerto Ayora 10/10 Exceptional (1 review) "We enjoyed our 6-night stay at Ariana's. The apartment was large and comfortable. Bedroom air conditioners were whisper quiet. We especially enjoyed the rooftop terrace with its soft breezes. It’s a 20 minute walk to the big tortoise statue and a few minutes more to the Mlecon, or a 2 taxi ride." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Dean P. $89 nightly $99 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h102721840.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/102000000/101740000/101738700/101738687/734f5e24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/102000000/101740000/101738700/101738687/5646c61b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, stereo](https://images.trvl-media.com/lodging/102000000/101740000/101738700/101738687/0cd636bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/102000000/101740000/101738700/101738687/ecbf06a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Endemic Suite - Apartamento con Azotea Vista 360 [](https://www.expedia.com/Puerto-Ayora-Hotels-Endemic-Suite-Apartamento-Con-Azotea-Vista-360.h101738687.Hotel-Information) Puerto Ayora $85 nightly $85 total Apr 1 - Apr 2 [](https://www.expedia.com/Puerto-Ayora-Hotels-Endemic-Suite-Apartamento-Con-Azotea-Vista-360.h101738687.Hotel-Information) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103060000/103058600/103058515/406de75c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/104000000/103060000/103058600/103058515/6408dac0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/104000000/103060000/103058600/103058515/7a5abddd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103060000/103058600/103058515/cb5f3162.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TWO Bedrooms Apartment ON THE First Floor IN Ariana\`s Galapagos Hostal [](https://www.expedia.com/Puerto-Ayora-Hotels-TWO-Bedrooms-Apartment-ON-THE-First-Floor-IN-Arianas-Galapagos-Hostal.h103058515.Hotel-Information) Puerto Ayora $89 nightly $99 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-TWO-Bedrooms-Apartment-ON-THE-First-Floor-IN-Arianas-Galapagos-Hostal.h103058515.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103200000/103193000/103192998/1cd8189f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/104000000/103200000/103193000/103192998/80e1d3dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103200000/103193000/103192998/c24a623e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/104000000/103200000/103193000/103192998/c544ac54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### KING-SIZE BED OR TWO TWIN BEDS SUITE ON SECOND FLOOR WITH CITY VIEW BALCONY [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h103192998.Hotel-Information) Puerto Ayora $50 nightly $55 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h103192998.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/113000000/112680000/112677400/112677301/ac8a7bfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112680000/112677400/112677301/4e605901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/113000000/112680000/112677400/112677301/3200cd5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/113000000/112680000/112677400/112677301/3543098c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora [](https://www.expedia.com/Puerto-Ayora-Hotels-2-Bedroom-Apartment-With-AC.h112677301.Hotel-Information) Puerto Ayora $88 nightly $88 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-2-Bedroom-Apartment-With-AC.h112677301.Hotel-Information) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/111000000/110140000/110134100/110134025/e9b7ef2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/111000000/110140000/110134100/110134025/a5ec6899.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/111000000/110140000/110134100/110134025/4776976b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/111000000/110140000/110134100/110134025/c74f8717.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### GALAPAGOS DIVER ESTUDIO. [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h110134025.Hotel-Information) Puerto Ayora 10/10 Exceptional (1 review) "Perfect start to finish. Very clean! Drinking water provided. The host helped us with a small hiccup regarding our transfer so we were able to catch the ferry to San Cristóbal with no problem. Highly recommend!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shannyn Z. $90 nightly $90 total Mar 23 - Mar 24 [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h110134025.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/113000000/112680000/112676500/112676466/a8ae6adc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112680000/112676500/112676466/9a885418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/113000000/112680000/112676500/112676466/6bc82d4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/113000000/112680000/112676500/112676466/607e65c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy 2-bedroom apartment in charming Puerto Ayora with AC, WiFi [](https://www.expedia.com/Puerto-Ayora-Hotels-Cozy-2-Bedroom-Apartment-In-Charming-Puerto-Ayora-With-AC.h112676466.Hotel-Information) Puerto Ayora $102 nightly $102 total Mar 24 - Mar 25 [](https://www.expedia.com/Puerto-Ayora-Hotels-Cozy-2-Bedroom-Apartment-In-Charming-Puerto-Ayora-With-AC.h112676466.Hotel-Information) ![1 bedroom, free WiFi, bed sheets, wheelchair access](https://images.trvl-media.com/lodging/60000000/59680000/59677200/59677109/1213239e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dishwasher, cookware/dishes/utensils, dining tables](https://images.trvl-media.com/lodging/60000000/59680000/59677200/59677109/3829be13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/60000000/59680000/59677200/59677109/3ed3ea89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/60000000/59680000/59677200/59677109/b1d46278.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galarous island apartments [](https://www.expedia.com/Puerto-Ayora-Hotels-Galarous-Island-Apartments.h59677109.Hotel-Information) Puerto Ayora $115 nightly $115 total Apr 1 - Apr 2 [](https://www.expedia.com/Puerto-Ayora-Hotels-Galarous-Island-Apartments.h59677109.Hotel-Information) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/c4aabc94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/7b3c7f31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/b385e31e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/3ca1da7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dominga Terrace [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h116005423.Hotel-Information) Unknown $101 nightly $101 total Apr 12 - Apr 13 [](https://www.expedia.com/Puerto-Ayora-Hotels-Vrbo-Property.h116005423.Hotel-Information) ![1 bedroom, free WiFi, bed sheets, wheelchair access](https://images.trvl-media.com/lodging/61000000/60600000/60597200/60597196/fae3fe2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/61000000/60600000/60597200/60597196/f6bbb628.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/61000000/60600000/60597200/60597196/c1ad2cd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/61000000/60600000/60597200/60597196/9ae4b365.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galarous serve you with quality and warmth in your home [](https://www.expedia.com/Puerto-Ayora-Hotels-Galarous-Serve-You-With-Quality-And-Warmth-In-Your-Home.h60597196.Hotel-Information) Puerto Ayora $99 nightly $99 total Apr 1 - Apr 2 [](https://www.expedia.com/Puerto-Ayora-Hotels-Galarous-Serve-You-With-Quality-And-Warmth-In-Your-Home.h60597196.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-05&endDate=2026-04-06®ionId=6053670&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz+Island%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=6053670&latLong=-0.639364%2C-90.337185&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=VACATION_HOME) Apartments [](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz+Island%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=6053670&latLong=-0.639364%2C-90.337185&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=APARTMENT) Aparthotels [](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz+Island%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=6053670&latLong=-0.639364%2C-90.337185&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=APART_HOTEL) Cabins [](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz+Island%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=6053670&latLong=-0.639364%2C-90.337185&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=CABIN) Condos [](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz+Island%2C+Gal%C3%A1pagos%2C+Ecuador®ionId=6053670&latLong=-0.639364%2C-90.337185&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=CONDO) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Island-Vacation-Rentals.d6053670.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Cruz-Island-Vacation-Rentals.d6053670.Travel-Guide-VacationRentals) ## Top Santa Cruz Island Hotel Reviews ![Hotel Ninfa](https://images.trvl-media.com/lodging/11000000/10090000/10087200/10087137/bf30a401_y.jpg) ### Hotel Ninfa 8/10 Good "Great to have the pool and seating area!" [](https://expedia.com/Puerto-Ayora-Hotels-Hotel-Ninfa.h10087137.Hotel-Information) ![Finch Bay Galapagos Hotel](https://images.trvl-media.com/lodging/2000000/1870000/1862600/1862515/62b50762_y.jpg) ### Finch Bay Galapagos Hotel 10/10 Excellent "We LOVED everything! We were sad to leave! Fantastic staff, stunning location and first class accommodations! The food was delicious and our time in the pool was relaxing! Thank you for a magical stay! " [](https://expedia.com/Puerto-Ayora-Hotels-Finch-Bay-Galapagos-Hotel.h1862515.Hotel-Information) ![Maidith Galapagos Inn](https://images.trvl-media.com/lodging/89000000/88480000/88474700/88474681/96c0ae07_y.jpg) ### Maidith Galapagos Inn 8/10 Good "Very helpful staff. The water in the room was very convenient. " [](https://expedia.com/Puerto-Ayora-Hotels-Maidith-Galapagos-Inn.h88474681.Hotel-Information) ![Posada del Mar](https://images.trvl-media.com/lodging/42000000/41950000/41941800/41941787/e7fb3ff1_y.jpg) ### Posada del Mar 10/10 Excellent "Excellent on all fronts, especially the service." [](https://expedia.com/Puerto-Ayora-Hotels-Posada-Del-Mar.h41941787.Hotel-Information) ![Angermeyer Waterfront Inn](https://images.trvl-media.com/lodging/5000000/4890000/4884900/4884897/2f892016_y.jpg) ### Angermeyer Waterfront Inn 10/10 Excellent "The staff goes far beyond in making your stay enjoyable. They were so helpful in facilitating our many adventures" [](https://expedia.com/Puerto-Ayora-Hotels-Angermeyer-Waterfront-Inn.h4884897.Hotel-Information) ![Hotel Cucuve](https://images.trvl-media.com/lodging/14000000/13150000/13147200/13147131/0a441130_y.jpg) ### Hotel Cucuve 10/10 Excellent "Great hotel. We left the luggages when we moved to Isabela. They let us use a room just to dry clothes. The location is great The staff is friendly. The room are spotless " [](https://expedia.com/Puerto-Ayora-Hotels-Hotel-Cucuve.h13147131.Hotel-Information) ![Blu Galapagos Sustainable Waterfront Lodge](https://images.trvl-media.com/lodging/3000000/2060000/2057800/2057779/f83773fa_y.jpg) ### Blu Galapagos Sustainable Waterfront Lodge 10/10 Excellent "Great spaces " [](https://expedia.com/Puerto-Ayora-Hotels-Galapagos-Habitat-By-Eco-Luxury-Group.h2057779.Hotel-Information) ![Ikala Galapagos Hotel](https://images.trvl-media.com/lodging/24000000/23690000/23688400/23688395/f2307f3e_y.jpg) ### Ikala Galapagos Hotel 10/10 Excellent "Amazing hotel, clean and beautiful. Special thanks for the attentive young man on reception. The hotel is close to everything, beautiful room and bathroom. Nice view of the pool. I enjoyed my drink on the rooftop at night as well. " [](https://expedia.com/Puerto-Ayora-Hotels-Ikala-Galapagos-Hotel.h23688395.Hotel-Information) ![Hotel el descanso del Guia](https://images.trvl-media.com/lodging/18000000/17530000/17525300/17525206/48310af4_y.jpg) ### Hotel el descanso del Guia 8/10 Good "The staff was amazing, so attentive and kind!" [](https://expedia.com/Puerto-Ayora-Hotels-Hotel-El-Descanso-Del-Guia.h17525206.Hotel-Information) ## Find out more about Santa Cruz Island **Everything you need to know about Santa Cruz Island vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz Island vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on. There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz Island vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Santa Cruz Island vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Santa Cruz Island. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz Island in high season. Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $76 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals! **How to find incredible deals on Santa Cruz Island rentals** At Expedia, we put the best Santa Cruz Island vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Santa Cruz Island rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz Island vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz Island. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.com - All accommodation types in Santa Cruz Island ### Trending destinations on Expedia.com - [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals) - [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals) - [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals) - [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals) - [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals) - [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals) - 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