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Santa Cruz Island Vacation Rentals

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Our top choices for Santa Cruz Island vacation rentals

Torre Mar Galapagos Boutique Suites

Torre Mar Galapagos Boutique Suites
3.0 star property
Puerto Ayora
9.0 out of 10, Wonderful, (16)
"Great room and a very walkable location. John was a fantastic host, has given me his whatsapp on day one and stayed in communication the whole time."
United States
Samuel
$114 nightly
The price is $114
Jan 5 - Jan 6, 2026
Torre Mar Galapagos Boutique Suites

Galapagos Coliving Ecuador Casa Tuna

Galapagos Coliving Ecuador Casa Tuna
3.0 star property
Puerto Ayora
Galapagos Coliving Ecuador Casa Tuna

¡Bienvenido a tu hogar isleño en Galápagos!

¡Bienvenido a tu hogar isleño en Galápagos!
Puerto Ayora
$102 nightly
The price is $102
Dec 25 - Dec 26
¡Bienvenido a tu hogar isleño en Galápagos!

This two-bedroom is a perfect island getaway.

This two-bedroom is a perfect island getaway.
Puerto Ayora, Santa Cruz Island
8.8 out of 10, Excellent, (5)
"Donna communicated with us before our trip to provide information about arrival and to offer transportation assistance from the airport. Once we were there she offered to arrange tours, suggest dining places and made reservations for us. She did everything she could to make our stay easy and enjoyable. On one of the tours she was our guide. That was so helpful."
United States
Cynthia H.
$178 nightly
The price is $201
Jan 9 - Jan 10, 2026
This two-bedroom is a perfect island getaway.

Jardin de Galápagos.

Jardin de Galápagos.
Galápagos Islands
$113 nightly
The price is $121
Dec 23 - Dec 24
Jardin de Galápagos.

The Oceanview two-bedroom with balcony

The Oceanview two-bedroom with balcony
Puerto Ayora, Santa Cruz Island
10.0 out of 10, Exceptional, (24)
"Excellent place to stay. Walking distance to everything. A small panderia (bakery) a block away has the best croissants for breakfast. Donna and team are phenomenal."
United States
Richard L.
$217 nightly
The price is $246
Jan 9 - Jan 10, 2026
The Oceanview two-bedroom with balcony

Charming studio in Puerto Ayora with all the services for a comfortable stay

Charming studio in Puerto Ayora with all the services for a comfortable stay
Puerto Ayora
$86 nightly
The price is $86
Dec 26 - Dec 27
Charming studio in Puerto Ayora with all the services for a comfortable stay

Casa Vacacional en Puerto Ayora, Santa Cruz, Galápagos

Casa Vacacional en Puerto Ayora, Santa Cruz, Galápagos
Puerto Ayora
10.0 out of 10, Exceptional, (1)
"Nice and beautiful house to stay very impressed "
United States
John
$110 nightly
The price is $110
Jan 2 - Jan 3, 2026
Casa Vacacional en Puerto Ayora, Santa Cruz, Galápagos

Apartment near the Sea

Apartment near the Sea
PUERTO AYORA SANTA CRUZ GALAPAGOS
8.8 out of 10, Excellent, (5)
"Really nice place!"
United States
Sefora
$130 nightly
The price is $170
Dec 23 - Dec 24
Apartment near the Sea

One Bedroom with private balcony

One Bedroom with private balcony
2.0 star property
Puerto Ayora, Santa Cruz Island
$145 nightly
The price is $164
Jan 9 - Jan 10, 2026
One Bedroom with private balcony

Courtyard Studio perfect for an active Galapagos adventure

Courtyard Studio perfect for an active Galapagos adventure
Puerto Ayora
$145 nightly
The price is $164
Jan 5 - Jan 6, 2026
Courtyard Studio perfect for an active Galapagos adventure

Beautiful rooms with ocean view in Galàpagos VerdeAzul

Beautiful rooms with ocean view in Galàpagos VerdeAzul
Puerto Ayora
$202 nightly
The price is $202
Jan 8 - Jan 9, 2026
Beautiful rooms with ocean view in Galàpagos VerdeAzul

Ocean view Penthouse

Ocean view Penthouse
2.0 star property
Puerto Ayora, Santa Cruz Island
10.0 out of 10, Exceptional, (1)
"We enjoyed our stay. The air conditioning was a welcome retreat after a day spent exploring. The views are amazing. "
United States
Greta S.
$180 nightly
The price is $204
Jan 9 - Jan 10, 2026
Ocean view Penthouse

2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora

2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora
Puerto Ayora
$88 nightly
The price is $88
Jan 5 - Jan 6, 2026
2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora

2 Suites Equipadas Para que tu Estancia sea Confortable,ven Galápagos Up Suites

2 Suites Equipadas Para que tu Estancia sea Confortable,ven Galápagos Up Suites
Puerto Ayora
$175 nightly
The price is $186
Dec 23 - Dec 24
2 Suites Equipadas Para que tu Estancia sea Confortable,ven Galápagos Up Suites

GALAPAGOS DIVER ESTUDIO.

GALAPAGOS DIVER ESTUDIO.
Puerto Ayora
10.0 out of 10, Exceptional, (1)
"Perfect start to finish. Very clean! Drinking water provided. The host helped us with a small hiccup regarding our transfer so we were able to catch the ferry to San Cristóbal with no problem. Highly recommend!"
United States
Shannyn Z.
$90 nightly
The price is $90
Dec 23 - Dec 24
GALAPAGOS DIVER ESTUDIO.

Galarous serve you with quality and warmth in your home

Galarous serve you with quality and warmth in your home
Puerto Ayora
$120 nightly
The price is $120
Dec 23 - Dec 24
Galarous serve you with quality and warmth in your home

Endemic Suite - Apartamento con Azotea Vista 360

Endemic Suite - Apartamento con Azotea Vista 360
Puerto Ayora
$85 nightly
The price is $85
Dec 23 - Dec 24
Endemic Suite - Apartamento con Azotea Vista 360

Galarous island apartments

Galarous island apartments
Puerto Ayora
$130 nightly
The price is $130
Dec 23 - Dec 24
Galarous island apartments

Galarous Island Suite comfortable and cozy

Galarous Island Suite comfortable and cozy
Puerto Ayora
$53 nightly
The price is $53
Dec 23 - Dec 24
Galarous Island Suite comfortable and cozy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Island Hotel Reviews

Find out more about Santa Cruz Island

Everything you need to know about Santa Cruz Island vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz Island vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz Island vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Cruz Island vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz Island. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz Island in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $90 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Cruz Island rentals

At Expedia, we put the best Santa Cruz Island vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz Island rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz Island vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz Island. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.