Find 5 Star Hotels in Defiance, MO from $135

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Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Defiance.
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO
The price is $152 total per night from Feb 8 to Feb 9
$152 total
per night
Feb 8 - Feb 9
8.6/10 Excellent! (1,001 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

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A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Find out more about Defiance

There's nothing wrong with enjoying the finer things in life. Add an extra layer of pleasure on your next trip to Defiance by treating yourself to the best of the best when it comes to accommodation. It's an ideal combination. There's no reason to delay a getaway to Defiance any longer. You'll join the multitudes of vacationers who have made Defiance so fashionable in the last year. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Our 5-star hotels in Defiance are the perfect places to relax in during your next escape.

Get a Great Deal on 5-Star Hotels in Defiance

You'll have a fantastic time at one of these 5-star hotels. Highly-rated eateries, concierges, and pillow-fluffing are all at the ready. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready to kick back and indulge. What kind of amenities will make your stay a wonderful one? A concierge to help you suggest the next attraction to visit? A deep-tissue massage to help your cares fall away? Plush carpeting, lip-smacking main courses, and even space for your family pet in some cases...these hotels have it all. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.

Yearning for experiences outside your hotel room? Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Defiance are waiting for you to relax after a busy day.

Your Getaway Starts Today

The results are in, and Defiance 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to indulge yourself. Opt for one of the 5-star hotels in Defiance today and soothe yourself in total tranquility tomorrow.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Defiance?
The amount you pay for a 5-star hotel in Defiance depends on things such as when you want to go and the length of your vacation. Our insider tip for scoring an awesome deal? Use our pricing filters to check out the available hotels for your preferred dates.

  • Search for the lowest price per night from $135

What makes a hotel 5 stars in Defiance?
In Defiance, a hotel must provide a specific number of upscale conveniences to earn 5 stars. These can include gourmet restaurants, on-site gyms, saunas and spas, luxury bathroom products, premium bedding and more. What also sets 5-star hotels apart is their outstanding standard of service. You can look forward to things like in-room massages, nightly turn-down services and concierge services. Some may even offer extra touches like welcome gifts.
Are there any 5-star all-inclusive resorts in Defiance?
Our handy filters are the best way to find exactly what you're looking for. Check the "All inclusive" and "5-star" boxes to see the most upscale resorts in Defiance where your accommodations, meals, entertainment and activities are included in the upfront price. At these escapes, your trip is pure relaxation and indulgence from the moment you pull up to the entrance.

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