Title: The Best 5 Star Hotels in Guayama from $306 | Expedia.com

[Guayama Travel Guide](https://expedia.com/Guayama.dx6204474)[Hotels in Guayama](https://expedia.com/Guayama-Hotels.d6204474.Travel-Guide-Hotels)[Vacation Rentals in Guayama](https://expedia.com/Guayama-Vacation-Rentals.d6204474.Travel-Guide-VacationRentals)[Flights to Guayama](https://expedia.com/Cheap-Flights-To-Guayama.d6204474.Travel-Guide-Flights)[Things to do in Guayama](https://expedia.com/Things-To-Do-In-Guayama.d6204474.Travel-Guide-Activities)[Car Rentals in Guayama](https://expedia.com/Car-Rentals-In-Guayama.d6204474.Car-Rental-Guide)[Guayama Vacation Packages](https://expedia.com/Guayama.d6204474.Destination-Travel-Guides)

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## Check availability on Guayama 5 Star Hotels

Tonight

[Mar 6 - Mar 7](https://www.expedia.com/Hotel-Search?regionId=6204474&startDate=2026-03-06&endDate=2026-03-07&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 7 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6204474&startDate=2026-03-07&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6204474&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6204474&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Guayama.

![Wyndham Palmas Beach and Golf Boutique Resort](https://images.trvl-media.com/lodging/31000000/30080000/30079000/30078988/31c35695_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Wyndham Palmas Beach and Golf Boutique Resort

170 Candelero Drive, Palmas del Mar Humacao 

$281 nightly

$306 total

Mar 8 - Mar 9

Total with taxes and fees

8.4/10 Very Good! (700 reviews)

[](https://expedia.com/Humacao-Hotels-Wyndham-Palmas-Beach-Golf-Resort.h30078988.Hotel-Information)

![Blue Horizon](https://images.trvl-media.com/lodging/111000000/110740000/110738900/110738832/4565ecc8_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Blue Horizon

Las Palmas Doradas Bldg.B, Apt. 400B 17 Humacao 

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F20%2F2026&endDate=3%2F21%2F2026&selected=110738832&PinnedHotelID=110738832&HadPinnedHotel=true&regionId=6204474)

10/10 Exceptional! (1 review)

[](https://expedia.com/Humacao-Hotels-Blue-Horizon.h110738832.Hotel-Information)

Still don't see what you're looking for?

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Guayama

Known as the 'City of Witches,' Guayama invites visitors to explore its historic Plaza Pública and the neoclassical San Antonio de Padua Church. Locals recommend sampling authentic criollo cuisine at Paseo Gautier Benítez before heading to nearby Carite Forest Reserve for refreshing mountain hikes.

[See all hotels in Guayama](https://www.expedia.com/Hotel-Search?startDate=2026-03-20&endDate=2026-03-21&adults=2&regionId=6204474)

![Beach Sunset](https://images.trvl-media.com/place/6204474/7111b202-6f8f-4f54-963a-bc470adc69f6.jpg?impolicy=fcrop&w=300&h=400&p=1&q=high)

## Top Guayama Hotel Reviews

## Find out more about Guayama

Ready to experience the next standard in luxury? We know you're thinking about it. Why not request total luxury during your excursion to Guayama? There's no reason to delay a getaway to Guayama any longer. You'll join the multitudes of vacationers who have made Guayama so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Guayama and get ready to enjoy the getaway of a lifetime.

### 5-Star Hotels in Guayama

You'll have a wonderful time at one of these 5-star hotels. Michelin-starred restaurants, concierges, and pillow-fluffing are all at the ready. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready to kick back and indulge. What creature comforts do you want in your lodging? A reflexology treatment that will leave you feeling like a million bucks? 24-hour room service, so you can order that Turkish coffee in the wee hours of the morning? A full-body massage to help your cares fall away? Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs. 

Yearning for experiences outside your hotel room? Don't worry. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Guayama are waiting for you to rest up after a busy day.

### Your Getaway Starts Today

The results are in, and Guayama 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to indulge yourself. Decide on one of our Guayama 5-star hotels today and settle down in the lap of luxury tomorrow.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Guayama?

> - Search for the lowest price per night from $306

### What makes a hotel 5 stars in Guayama?

### Are there any 5-star all-inclusive resorts in Guayama?

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