Title: The Best 5 Star Hotels in Mayesville, SC  | Expedia.com

[Mayesville Travel Guide](https://expedia.com/Mayesville.dx3000456025)[Hotels in Mayesville](https://expedia.com/Mayesville-Hotels.d3000456025.Travel-Guide-Hotels)[Vacation Rentals in Mayesville](https://expedia.com/Mayesville-Vacation-Rentals.d3000456025.Travel-Guide-VacationRentals)[Flights to Mayesville](https://expedia.com/Cheap-Flights-To-Mayesville.d3000456025.Travel-Guide-Flights)[Car Rentals in Mayesville](https://expedia.com/Car-Rentals-In-Mayesville.d3000456025.Car-Rental-Guide)[Mayesville Vacation Packages](https://expedia.com/Mayesville.d3000456025.Destination-Travel-Guides)

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## Check availability on Mayesville 5 Star Hotels

Tonight

[Mar 10 - Mar 11](https://www.expedia.com/Hotel-Search?regionId=3000456025&startDate=2026-03-10&endDate=2026-03-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 11 - Mar 12](https://www.expedia.com/Hotel-Search?regionId=3000456025&startDate=2026-03-11&endDate=2026-03-12&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=3000456025&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=3000456025&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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## Learn more about Mayesville

Venture to Riley Field and Crystal Lakes Golf Course—just two of the sights around Mayesville.

[See all hotels in Mayesville](https://www.expedia.com/Hotel-Search?startDate=2026-03-24&endDate=2026-03-25&adults=2&regionId=3000456025)

![Somewhere in rural South Carolina off a back road to my hometown. Saw the sunflower field and had to stop. ](https://images.trvl-media.com/place/3000456025/6a3c56a6-b58b-4522-a79c-15e608af44bf.jpg?impolicy=fcrop&w=899&h=675&p=1&q=high)

Photo by Caroline Nunez

## Top Mayesville Hotel Reviews

## Find out more about Mayesville

## Mayesville Five Star Hotel Information

If you’re searching for the celebrity treatment, the 5 star hotels in Mayesville are your dreams come true. From sprawling resorts to fancy hot spots, theseMayesville 5 star hotels immerse each traveler in the most elite experience money can buy. Want to unwind with a VIP-worthy spa treatment? These hotels have the leisure you're looking for.

Interested in sampling world-class cuisine? The on-site restaurants at the 5 stars hotels in Mayesville, South Carolina, let you do just that. You’ll even be able to book a room (or perhaps a penthouse?) at first-rate hotels near the region’s can’t-miss sights and most bustling shopping centers. Plus, many globe-trotters who visit Mayesville five star hotels find incredible rates and deep discounts thanks to Expedia, so you can score a deal without sacrificing an ounce of quality.

Everything you could possibly want (and a few things you didn’t know you needed): That’s what you’ll receive when you stay at Mayesville 5 star hotels.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Mayesville?

> - Search for the lowest price per night

### What makes a hotel 5 stars in Mayesville?

### Are there any 5-star all-inclusive resorts in Mayesville?

## Explore a world of travel with Expedia

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