A beach with waves, a boat, and palm trees.

Find 5 Star Hotels in Santa Clara from $166

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Santa Clara 5 Star Hotels

Tonight
Sep 17 - Sep 18
Tomorrow
Sep 18 - Sep 19
This weekend
Sep 18 - Sep 20
Next weekend
Sep 25 - Sep 27

Our top choices for Santa Clara 5-star hotels

A stone-walled, arched tunnel with a reflective water surface and a central column.
A breakfast buffet with various food items and a view of a garden through a glass enclosure.
A spa area with a central pool, stone walls, and arched ceilings.
A covered outdoor dining area with tables set for two, surrounded by large windows offering views of the outdoors.

1. Hotel La Compania Del Valle

Hotel La Compania Del Valle
El Valle de Anton
Canada
Christine
$208 nightly
$229 total
Sep 28 - Sep 29
Total with taxes and fees
Hotel La Compania Del Valle
A poolside lounge area with two white cushioned chairs and a lantern, surrounded by palm trees and a view of the ocean at sunset.
A two-story house with a swimming pool in front, surrounded by tropical vegetation.
A beachside lounge with wicker furniture, a wooden walkway, and palm trees.
A beach with a wooden pathway leading to a thatched-roof structure, surrounded by palm trees and wicker furniture.

2. The Buenaventura Golf & Beach Resort Panama, Autograph Collection

The Buenaventura Golf & Beach Resort Panama, Autograph Collection
El Chiru
United States
Mariella
$199 nightly
$219 total
Sep 23 - Sep 24
Total with taxes and fees
The Buenaventura Golf & Beach Resort Panama, Autograph Collection
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Clara.
Playa Blanca Beach Resort - All Inclusive

Playa Blanca Beach Resort - All Inclusive

115 Km Via Interamericana Rio Hato Cocle
$151 nightly
$166 total
Sep 30 - Oct 1
Total with taxes and fees
Playa Blanca Beach Resort - All Inclusive
Casa Blanca

Casa Blanca

5 95-5 San Carlos District San Carlos
Get rates
4/10 (1 review)
Casa Blanca
Casa Simona

Casa Simona

Calle Ranita de Oro El Valle de Antón Coclé Province
$248 nightly
$272 total
Oct 6 - Oct 7
Total with taxes and fees
Casa Simona
Still don't see what you're looking for?
See all properties in Santa Clara.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santa Clara

Pristine white sands stretch along Santa Clara Beach where families gather for weekend picnics and sunset swims. Nearby Farallon Island offers excellent snorkeling opportunities, while La Casa de Lourdes Outdoor Spa provides a tranquil retreat after days spent under the tropical sun.

See all hotels in Santa Clara
A beach with waves, a boat, and palm trees.

Top Santa Clara Hotel Reviews

The Buenaventura Golf & Beach Resort Panama, Autograph Collection

The Buenaventura Golf & Beach Resort Panama, Autograph Collection

8/10 Good
"We loved Criollo restaurant, great Peruvian dishes!"
Mariella 2-night trip
Posted 4 days ago
The Buenaventura Golf & Beach Resort Panama, Autograph Collection

Find out more about Santa Clara

Ready for an incredible adventure? Add even more luxury on your next trip to Santa Clara by treating yourself to the best of the best when it comes to lodging. It's an ideal combination. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Santa Clara so popular in the last year. There's no reason to delay a getaway to Santa Clara any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Reserve one of our 5-star hotels in Santa Clara and indulge in the finer things in life for a while. What are you waiting for?

Book the Best Santa Clara 5-Star Hotels

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, top-notch customer care, and rejuvenating spa offerings are all on offer. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. How do you want to relax? A mud wrap treatment that will leave you feeling like a million bucks? 24-hour room service, so you can order that filet mignon in the wee hours of the morning? A full-body massage to help your cares fall away?

Ready for experiences outside your hotel room? You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Santa Clara are waiting for you to rest up after a busy day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Your Getaway Starts Today

The results are in, and Santa Clara 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Select one of our Santa Clara 5-star hotels today and soothe yourself in luxe surroundings tomorrow.

Frequently asked questions

What are the best 5-star hotels in Santa Clara?
If you're looking for a 5-star experience, The Buenaventura Golf & Beach Resort Panama, Autograph Collection offers one of the best of them according to Expedia customer reviews. Choose this Santa Clara getaway and get ready for first-rate service, well-appointed guest rooms and top-notch facilities.
How much does it cost to stay in a 5-star hotel in Santa Clara?
The amount you pay for a 5-star hotel in Santa Clara depends on factors like when you plan to travel and the length of your break. Our top tip for scoring an awesome deal? Use our pricing filters to check out the available options for your preferred dates.
  • Search for the lowest price per night from $166
What makes a hotel 5 stars in Santa Clara?
From fine dining venues and all-day gyms to pools and dreamy bedding, the 5-star experience in Santa Clara is all about comfort and indulgence. But it takes more than just top-notch perks to receive a 5-star rating. Stays also have to deliver remarkable services like massage treatments, dry cleaning and laundry and a nightly turn-down service.

Explore a world of travel with Expedia