Byron Vacations from $628

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Your Byron Vacation

Book a tailored Byron vacation package that includes only the things you need and nothing you don't. Good for bars and pubs, history and culture, think about staying in the neighborhood of Downtown Rochester. There's plenty to put on your must-do list during your trip to Byron, starting with leading attractions such as Oxbow Park and Douglas Trail. A couple of quick clicks is all it takes to put together the ultimate Byron vacation on Expedia.

The Latest Byron vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
Downtown Rochester
Price was $653, price is now $628 per person
$628
per person
Mar 30 - Apr 1
found 1 day ago
Roundtrip non-stop flight included
Indianapolis (IND) to Rochester (RST)
8.8/10 Excellent! (867 reviews)
Clean room and friendly staff! Great breakfast at restaurant as well!

Reviewed on Jan 6, 2026

The Berkman

The Berkman

3 out of 5
Folwell
Price was $830, price is now $769 per person
$769
per person
Mar 18 - Mar 20
found 3 hours ago
Roundtrip non-stop flight included
Cleveland (CLE) to Rochester (RST)
9.6/10 Exceptional! (363 reviews)
It was a bit tricky finding our area we could park in but it worked out.

Reviewed on Jan 1, 2026

Aspen Select

Aspen Select

3.5 out of 5
Kutzky Park
Price was $767, price is now $729 per person
$729
per person
Mar 18 - Mar 20
found 3 hours ago
Roundtrip non-stop flight included
Cleveland (CLE) to Rochester (RST)
8.4/10 Very Good! (1,003 reviews)
Old but clean, breakfast could have been better, location was great

Reviewed on Jan 8, 2026

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

3 out of 5
Kutzky Park
Price was $815, price is now $779 per person
$779
per person
Mar 18 - Mar 20
found 3 hours ago
Roundtrip non-stop flight included
Cleveland (CLE) to Rochester (RST)
9.2/10 Wonderful! (469 reviews)
Dry clean, never building, decent breakfast Staff was friendly but not considerate of a handicapped person (myself) as far as offering a hand with getting things to and from my room. Cleaning staff were very considerate and helpful. 5 stars for them for sure. Room was missing some basic items like a building map, local restaurants advertising even a he restaurant right in the building didn’t have a menu in the room. Overall stay was good.

Reviewed on Jan 9, 2026

Country Inn & Suites Rochester South Mayo Clinic

Country Inn & Suites Rochester South Mayo Clinic

3 out of 5
Price was $743, price is now $717 per person
$717
per person
Mar 18 - Mar 20
found 3 hours ago
Roundtrip non-stop flight included
Cleveland (CLE) to Rochester (RST)
8.4/10 Very Good! (1,001 reviews)
The evening shift attendant was extremely helpful. Rooms were nice and clean. Breakfast was delicous , Will stay at the hotel in the future.

Reviewed on Jan 8, 2026

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Discover the most popular places to visit in Byron

Oxbow Park

Explore the great outdoors at Oxbow Park, a lovely green space in Byron. Check out the charming coffeehouses or top-notch restaurants in this walkable area.

Oxbow Park

Byron Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Jan 11 to Jan 12
$146 total
Jan 11 - Jan 12
Total with taxes and fees
8.2/10 Very Good! (1,853 reviews)
No free breakfast

Reviewed on Jan 8, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Jan 11 to Jan 12
$152 total
Jan 11 - Jan 12
Total with taxes and fees
7.8/10 Good! (1,528 reviews)
Clean big room close to the Mayo

Reviewed on Dec 31, 2025

Kahler Inn and Suites - Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
Fully refundable
$80 nightly
The price is $92 total per night from Jan 24 to Jan 25
$92 total
Jan 24 - Jan 25
Total with taxes and fees
8.8/10 Excellent! (900 reviews)
Clean room and friendly staff! Great breakfast at restaurant as well!

Reviewed on Jan 6, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
See all 388 properties in Byron
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Byron Vacation Packages

Byron Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Rochester Intl. Airport (RST)
Population
5,300
Top Sights
Rochester Civic Theater, Minnesota Childrens Museum and Cascade Lake Beach

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Frequently asked questions

How much does a Byron vacation package cost?
Offering great value package deals from $628 on Expedia, you'll be thrilled with how little a vacation to Byron costs! Expedia's packages make travel planning easier and save you more.
What are the cheapest months to go to Byron?
December, January and February are the best times to look for cheap Byron vacation packages. Choosing to travel in less busy months means you'll typically find lower prices on accommodations and flights.
How many days is enough for Byron?
Generally, a handful of days is enough to tick off the main sights during your Byron vacation. However, if you'd like to have more time to unwind or take day trips, consider extending your trip.
How to find the best Byron package deals?
Landing a cheap Byron package deal is a breeze with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your budget range, add some filters and see what's available. You can tailor your search by "Amenities," "Property type," "Traveler experience" and more. Sort the results by "Price: low to high" to discover the most pocket-friendly Byron package deals. Want a simple trick to score even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Byron vacation as a package?
You can enjoy significant savings on your Byron break by booking a personalized vacation package. Click on the "Package" heading, then enter your destination and travel dates to view the best hotel and flight prices. Bundle everything into a neat package and you can save hundreds of dollars. Consider adding a car rental and you may land a better deal.
When to book a vacation package to Byron?
If you have your Byron travel dates finalized, book as soon as you can to bag some incredible deals. With Expedia, you can generally reserve some flights up to a year in advance. Prefer spontaneous trips? Our last-minute deals are perfect for setting off on a whim.
Does Expedia offer Book Now, Pay Later Byron vacation packages?
If you're anything like us, you love traveling but don't love the price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can break down the overall cost of your Byron vacation over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure cheap vacation packages with payment plans as soon as you spot them.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.