Title: Byron Vacation Rentals from $120: Search Short-Term Rentals | Expedia.com

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## Check prices for these dates

In two weeks

[Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=553248623858895563&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 15 - May 17](https://www.expedia.com/Hotel-Search?regionId=553248623858895563&startDate=2026-05-15&endDate=2026-05-17&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 12 - Jun 14](https://www.expedia.com/Hotel-Search?regionId=553248623858895563&startDate=2026-06-12&endDate=2026-06-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 10 - Jul 12](https://www.expedia.com/Hotel-Search?regionId=553248623858895563&startDate=2026-07-10&endDate=2026-07-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Byron vacation rentals

![Lobby](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/5776b64a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/05c31332.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Billiards](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/6b44b2f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/50c22b07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Berkman

[](https://www.expedia.com/Rochester-Hotels-Berkman-Hotel.h46291477.Hotel-Information)

Folwell

9.6/10

Exceptional

(389 reviews)

"Everything was excellent, second time staying there. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carolyn

$116 nightly

$133 total

Mar 21 - Mar 22

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Berkman-Hotel.h46291477.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/89000000/88140000/88134300/88134280/b289cba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/89000000/88140000/88134300/88134280/w904h683x60y0-3cf0fc10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/89000000/88140000/88134300/88134280/beed0082.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/89000000/88140000/88134300/88134280/w504h639x260y44-1bc74fd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Valley Cabin

[](https://www.expedia.com/Spring-Valley-Hotels-Valley-Cabin.h88134280.Hotel-Information)

Spring Valley

9.2/10

Wonderful

(7 reviews)

"Great property with plenty of outdoor activities. Had fun fishing the stream and exploring the area. Dan is a great host and I will be visiting again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

JAKE I.

$118 nightly

$127 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Spring-Valley-Hotels-Valley-Cabin.h88134280.Hotel-Information)

![Two-Bedroom Apartment - Mobility Accessible/Non-Smoking | In-room safe, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/14000000/13180000/13173700/13173672/8523d385.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/14000000/13180000/13173700/13173672/4cb3352e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/14000000/13180000/13173700/13173672/a8a8ab63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/14000000/13180000/13173700/13173672/fa38f94a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Broadway Plaza, Trademark Collection by Wyndham

[](https://www.expedia.com/Rochester-Hotels-Broadway-Plaza.h13173672.Hotel-Information)

Downtown Rochester

9.2/10

Wonderful

(174 reviews)

"As always excellent staff, clean and comfortable rooms. Great central location. "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Anita

$180 nightly

$207 total

Apr 3 - Apr 4

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Broadway-Plaza.h13173672.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/101000000/100200000/100194400/100194373/dc05b783.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100200000/100194400/100194373/c7575fb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/101000000/100200000/100194400/100194373/a6e50dd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/101000000/100200000/100194400/100194373/a6c285de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 2 bedroom apartment in downtown Zumbrota. Sleeps 4-6.

[](https://www.expedia.com/Zumbrota-Hotels-2-Bedroom-Apartment-In-Downtown-Zumbrota-Sleeps-4-6.h100194373.Hotel-Information)

Zumbrota

10/10

Exceptional

(62 reviews)

"This hostess thought about everything and its the only placed to stay that is nice within 30 minutes of where we were and affordable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Janelle

$119 nightly

$128 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Zumbrota-Hotels-2-Bedroom-Apartment-In-Downtown-Zumbrota-Sleeps-4-6.h100194373.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/116000000/115540000/115537100/115537064/a164ebdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/116000000/115540000/115537100/115537064/840fddd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/116000000/115540000/115537100/115537064/54a551fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/116000000/115540000/115537100/115537064/ba1a2203.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quiet 3 BDR Home- private sauna & skyline view- close to downtown & Mayo Clinic

[](https://www.expedia.com/Rochester-Hotels-Quiet-3-BDR-Home-Private-Sauna-Skyline-View-Close-To-Downtown-Mayo-Clinic.h115537064.Hotel-Information)

Rochester

10/10

Exceptional

(2 reviews)

"This was a fantastic experience, far better than anticipated! Only a couple of comments: this high tech house was a little over the head of my crew and a guidebook to show us how to use all those remotes would have been most welcome. And one of my folks was looking for a can opener… We had a lovely time and the next convention we have in Rochester I will book here again without hesitation! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Patricia B.

$391 nightly

$450 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Quiet-3-BDR-Home-Private-Sauna-Skyline-View-Close-To-Downtown-Mayo-Clinic.h115537064.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/57000000/56500000/56499500/56499457/0c8268f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/57000000/56500000/56499500/56499457/e840085d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, DVD player, offices](https://images.trvl-media.com/lodging/57000000/56500000/56499500/56499457/e7f08b6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/57000000/56500000/56499500/56499457/1bc7a204.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Suite in Rochester | Free Breakfast + Shared Pool & Hot Tub. Near Mayo Clinic!

[](https://www.expedia.com/Rochester-Hotels-Cozy-Suite-In-Rochester-Free-Breakfast-Shared-Pool-Hot-Tub-Near-Mayo-Clinic.h56499457.Hotel-Information)

Rochester

9.4/10

Exceptional

(6 reviews)

"The two room suite was perfect for the four of us."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Judy S.

$195 nightly

$224 total

Mar 20 - Mar 21

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Cozy-Suite-In-Rochester-Free-Breakfast-Shared-Pool-Hot-Tub-Near-Mayo-Clinic.h56499457.Hotel-Information)

![Smart TV, books](https://images.trvl-media.com/lodging/119000000/118970000/118966800/118966768/d46138d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/119000000/118970000/118966800/118966768/ac92f8ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/119000000/118970000/118966800/118966768/f588a75c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118970000/118966800/118966768/40c65c2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Meet Bev, a charming 2-bedroom, pet-friendly home in Rochester

[](https://www.expedia.com/Rochester-Hotels-Meet-Bev.h118966768.Hotel-Information)

Washington

9.8/10

Exceptional

(23 reviews)

"Location was great, home was clean and well stocked. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jessica T.

$172 nightly

$198 total

Mar 27 - Mar 28

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Meet-Bev.h118966768.Hotel-Information)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119760000/119751900/119751899/bde39aeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/120000000/119760000/119751900/119751899/d062e60d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/120000000/119760000/119751900/119751899/4a112a03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119760000/119751900/119751899/11aaf550.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester

[](https://www.expedia.com/Rochester-Hotels-Meet-Don-A-Modern.h119751899.Hotel-Information)

Slatterly Park

10/10

Exceptional

(18 reviews)

"This is a great property! Highly recommend!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Anne G.

$207 nightly

$238 total

Mar 19 - Mar 20

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Meet-Don-A-Modern.h119751899.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/123000000/122670000/122668000/122667923/a6a0e908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/123000000/122670000/122668000/122667923/15722e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122670000/122668000/122667923/9da21b22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122670000/122668000/122667923/3e543e44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Delightful cabin with AC in Racine

[](https://www.expedia.com/Racine-Hotels-Delightful-Cabin-With-AC-In-Racine.h122667923.Hotel-Information)

Racine

$145 nightly

$156 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Racine-Hotels-Delightful-Cabin-With-AC-In-Racine.h122667923.Hotel-Information)

![Private kitchen](https://images.trvl-media.com/lodging/124000000/123510000/123503200/123503101/f2695db6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/124000000/123510000/123503200/123503101/05e577d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/124000000/123510000/123503200/123503101/f723d7f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/124000000/123510000/123503200/123503101/fd62ea6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Custom Luxury Rambler in Highland Hills, Rochester

[](https://www.expedia.com/Rochester-Hotels-Custom-Luxury-Rambler-In-Highland-Hills.h123503101.Hotel-Information)

Rochester

$524 nightly

$534 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Custom-Luxury-Rambler-In-Highland-Hills.h123503101.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/108000000/107910000/107903000/107902961/6c0e8062.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/108000000/107910000/107903000/107902961/84b32a8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/108000000/107910000/107903000/107902961/w1422h960x18y0-349de2b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/108000000/107910000/107903000/107902961/6299361d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lux 3 BR mins to Mayo & Dwtwn I Charming Haven

[](https://www.expedia.com/Rochester-Hotels-Lux-3-BR-Mins-To-Mayo-Dwtwn-I-Charming-Haven.h107902961.Hotel-Information)

Rochester

10/10

Exceptional

(6 reviews)

"This property had everything we needed. Super cute and simple decor, comfortable beds and clean. We would stay here again!! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Anonymous traveler

$385 nightly

$441 total

Mar 21 - Mar 22

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Lux-3-BR-Mins-To-Mayo-Dwtwn-I-Charming-Haven.h107902961.Hotel-Information)

![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/116000000/115290000/115288200/115288129/bc2bfa15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/116000000/115290000/115288200/115288129/fa3b4e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/116000000/115290000/115288200/115288129/b11e3c72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/116000000/115290000/115288200/115288129/a537e54f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy 3BR near Mayo and downtown. Charming, spotless, and designed for comfort with restful bedrooms, a stocked kitchen, and two welcoming living spaces. Perfect for Mayo visits, business trips, or family stays. Dogs allowed, too.

[](https://www.expedia.com/Rochester-Hotels-Lux-3BR-Cozy-Nook-I-Mins-To-Mayo-Dwtwn-I-Pets.h115288129.Hotel-Information)

Rochester

9.8/10

Exceptional

(7 reviews)

"Nice place to stay, close to all the activities we wanted to do."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kimberly K.

$395 nightly

$452 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Lux-3BR-Cozy-Nook-I-Mins-To-Mayo-Dwtwn-I-Pets.h115288129.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/112000000/111290000/111284700/111284608/26025d59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111290000/111284700/111284608/c22c98da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111290000/111284700/111284608/48fb1f69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111290000/111284700/111284608/c10914f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 2-bedroom apartment in delightful Rochester with WiFi, AC

[](https://www.expedia.com/Rochester-Hotels-Charming-2-Bedroom-Apartment-In-Delightful-Rochester-With-WiFi.h111284608.Hotel-Information)

Meadow Park

10/10

Exceptional

(1 review)

"Quiet, clean and in a friendly neighborhood. Staying there took some of the stress out of my Mayo Clinic visits. I always worry about my follow-up visits, but a good quiet place to stay helps me let that go."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maria L E.

$140 nightly

$201 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Charming-2-Bedroom-Apartment-In-Delightful-Rochester-With-WiFi.h111284608.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/124000000/123510000/123503100/123503100/c55dc79c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/124000000/123510000/123503100/123503100/73abe2a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/124000000/123510000/123503100/123503100/70a83f9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/124000000/123510000/123503100/123503100/8a7021fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 1st Luxury Residential Elevator rooftop deck

[](https://www.expedia.com/Rochester-Hotels-1st-Luxury-Residential-Elevator-Rooftop-Deck.h123503100.Hotel-Information)

Rochester

$458 nightly

$467 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-1st-Luxury-Residential-Elevator-Rooftop-Deck.h123503100.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83550000/83544300/83544246/6d7da33d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/84000000/83550000/83544300/83544246/317098ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/84000000/83550000/83544300/83544246/9afb93b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/84000000/83550000/83544300/83544246/41531a0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cheshire House // Family Home, Fenced Yard, Pet Friendly, 2 mi from Mayo Clinic

[](https://www.expedia.com/Rochester-Hotels-Vrbo-Property.h83544246.Hotel-Information)

Rochester

10/10

Exceptional

(41 reviews)

"Great place to stay. Loved the fenced in yard for our dogs."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tara C.

$352 nightly

$405 total

Mar 21 - Mar 22

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Vrbo-Property.h83544246.Hotel-Information)

![Private kitchen](https://images.trvl-media.com/lodging/124000000/123510000/123503200/123503102/4055ea7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi](https://images.trvl-media.com/lodging/124000000/123510000/123503200/123503102/b22326e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/124000000/123510000/123503200/123503102/5a356a19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/124000000/123510000/123503200/123503102/c995ce5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Luxurious Sweet Escape stunning custom Home!

[](https://www.expedia.com/Rochester-Hotels-Luxurious-Sweet-Escape-Stunning-Custom-Home.h123503102.Hotel-Information)

Rochester

$448 nightly

$457 total

Mar 20 - Mar 21

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Luxurious-Sweet-Escape-Stunning-Custom-Home.h123503102.Hotel-Information)

![Smart TV, books](https://images.trvl-media.com/lodging/72000000/71370000/71363500/71363416/6246ff2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/72000000/71370000/71363500/71363416/6c81e0ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/72000000/71370000/71363500/71363416/512da12c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/72000000/71370000/71363500/71363416/9c7af335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Little House // Stylish & Cozy \~ 2 mi from Mayo Clinic

[](https://www.expedia.com/Rochester-Hotels-Stylish-Cozy-2-Mi-From-Mayo-Clinic.h71363416.Hotel-Information)

Slatterly Park

10/10

Exceptional

(21 reviews)

"I love staying in their properties. I always know I am going to be comfortable and have a great stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carissa W.

$194 nightly

$223 total

Mar 19 - Mar 20

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Stylish-Cozy-2-Mi-From-Mayo-Clinic.h71363416.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/76000000/75980000/75971000/75970993/55b36ae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi](https://images.trvl-media.com/lodging/76000000/75980000/75971000/75970993/cb06b343.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/76000000/75980000/75971000/75970993/1cb47d4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/76000000/75980000/75971000/75970993/08c06c84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apple Blossom Cottage // 2 Miles from Downtown \~ 10 Min to Mayo

[](https://www.expedia.com/Rochester-Hotels-Apple-Blossom-Cottage-2-Miles-From-Downtown-10-Min-To-Mayo.h75970993.Hotel-Information)

Rochester

9.8/10

Exceptional

(12 reviews)

"Very comfortable home away from home"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

ROBERT B.

[](https://www.expedia.com/Rochester-Hotels-Apple-Blossom-Cottage-2-Miles-From-Downtown-10-Min-To-Mayo.h75970993.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/57000000/56500000/56499100/56499019/13771477.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/57000000/56500000/56499100/56499019/364d4839.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/57000000/56500000/56499100/56499019/1cb15748.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/57000000/56500000/56499100/56499019/f6e66ebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Studio Suite! Free Breakfast + Shared Pool & Hot Tub. Great for Business Travelers!

[](https://www.expedia.com/Rochester-Hotels-Studio-Suite-Free-Breakfast-Shared-Pool-Hot-Tub-Great-For-Business-Travelers.h56499019.Hotel-Information)

Rochester

8.6/10

Excellent

(4 reviews)

"Very nice and convenient stay. Everything we needed and extremely well maintained room and kitchen. Loved it and the responsiveness out our hosts!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rick H.

$154 nightly

$177 total

Mar 21 - Mar 22

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Studio-Suite-Free-Breakfast-Shared-Pool-Hot-Tub-Great-For-Business-Travelers.h56499019.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/52000000/51270000/51267300/51267208/90-3e521435.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/52000000/51270000/51267300/51267208/18c8f73f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/52000000/51270000/51267300/51267208/90-3a8a456d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/52000000/51270000/51267300/51267208/0cc41438.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Magical Nest Hideaway

[](https://www.expedia.com/Rochester-Hotels-Magical-Nest-Hideaway.h51267208.Hotel-Information)

Rochester

10/10

Exceptional

(141 reviews)

"Great place to stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Matthew S.

$104 nightly

$120 total

Mar 27 - Mar 28

Total with taxes and fees

[](https://www.expedia.com/Rochester-Hotels-Magical-Nest-Hideaway.h51267208.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-30&endDate=2026-03-31&regionId=553248623858895563&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Byron%2C+Minnesota%2C+United+States+of+America&regionId=553248623858895563&latLong=44.032742%2C-92.645462&adults=2&startDate=2026-06-14&d1=2026-06-14&endDate=2026-06-17&d2=2026-06-17&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Byron%2C+Minnesota%2C+United+States+of+America&regionId=553248623858895563&latLong=44.032742%2C-92.645462&adults=2&startDate=2026-06-14&d1=2026-06-14&endDate=2026-06-17&d2=2026-06-17&lodging=VACATION_HOME)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Byron%2C+Minnesota%2C+United+States+of+America&regionId=553248623858895563&latLong=44.032742%2C-92.645462&adults=2&startDate=2026-06-14&d1=2026-06-14&endDate=2026-06-17&d2=2026-06-17&lodging=CONDO)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Byron%2C+Minnesota%2C+United+States+of+America&regionId=553248623858895563&latLong=44.032742%2C-92.645462&adults=2&startDate=2026-06-14&d1=2026-06-14&endDate=2026-06-17&d2=2026-06-17&lodging=APART_HOTEL)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Byron%2C+Minnesota%2C+United+States+of+America&regionId=553248623858895563&latLong=44.032742%2C-92.645462&adults=2&startDate=2026-06-14&d1=2026-06-14&endDate=2026-06-17&d2=2026-06-17&lodging=APARTMENT)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Byron%2C+Minnesota%2C+United+States+of+America&regionId=553248623858895563&latLong=44.032742%2C-92.645462&adults=2&startDate=2026-06-14&d1=2026-06-14&endDate=2026-06-17&d2=2026-06-17&lodging=COTTAGE)

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## Top Byron Hotel Reviews

![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](https://images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg)

### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

4/10 Poor

"Breakfast was at 7am on weekends. Wish that was up front sonce we had wrestling tournaments for 2 days and all familys had to leave before both days. Said 6am when booking Cable and internet was out 1st night. Most likely find somewhere else next time "

[](https://expedia.com/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information)

![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/1062bbaa_y.jpg)

### Kahler Grand Hotel

10/10 Excellent

"Clean updated room and bathroom. Close to Mayo Clinic. Very helpful and friendly staff. Pool is nice - not used by many people. "

[](https://expedia.com/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information)

![Hyatt House Rochester/Mayo Clinic Area](https://images.trvl-media.com/lodging/57000000/56840000/56833100/56833067/369065b1_y.jpg)

### Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"It was a nice relax place "

[](https://expedia.com/Rochester-Hotels-Hyatt-House-RochesterMayo-Clinic.h56833067.Hotel-Information)

![Hotel Indigo Rochester – Mayo Clinic Area by IHG](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/bba1b373_y.jpg)

### Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"Good hotels "

[](https://expedia.com/Rochester-Hotels-Hotel-Indigo-Rochester-Downtown.h5327.Hotel-Information)

![Spark by Hilton Rochester South](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/c7dc0b32_y.jpg)

### Spark by Hilton Rochester South

10/10 Excellent

"Overall great!"

[](https://expedia.com/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information)

![Kahler Inn and Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/41a1c74b_y.jpg)

### Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"Yes"

[](https://expedia.com/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information)

![Hampton Inn Rochester-South](https://images.trvl-media.com/lodging/1000000/20000/16600/16522/c73455d9_y.jpg)

### Hampton Inn Rochester-South

8/10 Good

"Small rooms with bulky dresser/table. For a few nights it was do able. We were on the 3rd floor and the water pressure was terrible. For a girl with longer hair—it took 20 mins to wash out. Talked to another guest on the first floor they had no problems with water pressure. The picture hanging in the bathroom on the wall was dirty. That should be cleaned every time the room gets cleaned. Would I stay here again—yes! "

[](https://expedia.com/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information)

![Best Western Rochester Hotel Mayo Clinic Area/St. Mary's](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/w3837h2560x3y0-1092e125_y.jpg)

### Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"Love this hotel "

[](https://expedia.com/Rochester-Hotels-Best-Western-Rochester-Hotel-Mayo-Clinic-AreaSt-Marys.h3682.Hotel-Information)

![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg)

### AmericInn by Wyndham Rochester Near Mayo Clinic

4/10 Poor

"The property is severly run down. Needs an update soon or you will start losing patrons."

[](https://expedia.com/Rochester-Hotels-AmericInn-By-Wyndham-Rochester-Near-Mayo-Clinic.h8008.Hotel-Information)

## Find out more about Byron

**Everything you need to know about Byron vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Byron vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Byron vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Byron vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Byron. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Byron in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $120 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Byron rentals**

At Expedia, we put the best Byron vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Byron rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Byron vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Byron. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
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- [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)
- [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals)
- [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals)
- [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals)
- [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals)
- [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)
- [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals)
- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Byron ](https://expedia.com/Byron-Private-Vacation-Homes.d553248623858895563-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Apartments in Byron ](https://expedia.com/Byron-Apartments.d553248623858895563-aaApartments.Travel-Guide-Accommodation)
- [Condo Rentals in Byron ](https://expedia.com/Byron-Condos.d553248623858895563-aaCondos.Travel-Guide-Accommodation)
- [Cottages in Byron ](https://expedia.com/Byron-Cottages.d553248623858895563-aaCottages.Travel-Guide-Accommodation)
- [Motels in Byron ](https://expedia.com/Byron-Motels.d553248623858895563-aaMotels.Travel-Guide-Accommodation)
- [Cabin Rentals in Byron ](https://expedia.com/Byron-Cabins.d553248623858895563-aaCabins.Travel-Guide-Accommodation)
- [Farmstay in Byron ](https://expedia.com/Byron-Agritourism.d553248623858895563-aaAgritourism.Travel-Guide-Accommodation)
- [Aparthotels in Byron ](https://expedia.com/Byron-Apart-Hotels.d553248623858895563-aaApartHotels.Travel-Guide-Accommodation)
- [B&B in Byron ](https://expedia.com/Byron-Bed-And-Breakfast.d553248623858895563-aaBedAndBreakfast.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find vacation rentals in Byron?

### What's the top vacation rental that Byron has to offer?

### What’s there to see and do in Byron?

### What’s a vacation rental in Byron like?

### Expedia's Latest Trends

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- [Flights to RST](https://expedia.com/Cheap-Flights-To-Rochester.d3041.Travel-Guide-Flights)

Cars

- [Car rentals in Rochester](https://expedia.com/Car-Rentals-In-Rochester.d3041.Car-Rental-Guide)
- [Car rentals in Duluth](https://expedia.com/Car-Rentals-In-Duluth.d1029.Car-Rental-Guide)

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