Title: Car Rental Santa Ana - Expedia.com [Santa Ana Travel Guide](https://expedia.com/Panama-City-Santa-Ana.dx553248623199107606)[Hotels in Santa Ana](https://expedia.com/Santa-Ana-Panama-City-Hotels.0-n553248623199107606-0.Travel-Guide-Filter-Hotels)[Flights to Panama City](https://expedia.com/Cheap-Flights-To-Panama-City.d2897.Travel-Guide-Flights)[Things to do in Panama City](https://expedia.com/Things-To-Do-In-Panama-City.d2897.Travel-Guide-Activities)[Santa Ana Vacations](https://expedia.com/Santa-Ana.d553248623199107606.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/553248623199107606/b6ad0470-c1f6-4b60-92c8-74bd8158bfc9.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rental Santa Ana ## Search and Compare from Car Companies in Santa Ana ## Featured car rental suppliers Compare from agencies ![car suppliers logo](https://forever.travel-assets.com/flex/flexmanager/images/2022/02/16/car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car rentals - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car rentals [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Car Deals in Santa Ana \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people Panama City, Panamá Province, PAN ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Ana,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199107606&date1=4/8/2026&date2=4/10/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people Panama City, Panamá Province, PAN ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Ana,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199107606&date1=4/8/2026&date2=4/10/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people Panama City, Panamá Province, PAN ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Ana,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199107606&date1=4/8/2026&date2=4/10/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people Panama City, Panamá Province, PAN ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Ana,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199107606&date1=4/8/2026&date2=4/10/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car rentals in Santa Ana [View all cars](https://expedia.com/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Santa%20Ana,%20Panama%20City,%20Panam%C3%A1%20Province,%20Panama&dpln=553248623199107606&date1=4/8/2026&date2=4/10/2026&crfrr=defaultFlex&SearchType=Place) ## What you need to know for your Santa Ana car rental ## Car Rental Information | Popular car types | [SUV](https://www.expedia.com/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.com/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.com/lp/b/car-rental/economy?rfrr=car.table.Economy) | | ------------------------------------------------ | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available | | | Our best deal of the day | | | Our second best deal of the day | | | Our third best deal of the day | | | From the airport to your hotel | [Airport Transportation](https://www.expedia.com/ground-transfers?rfrr=car.table.AirportTransportation) | | From popular domestic and international airports | [Airport Car Rentals](https://www.expedia.com/lp/b/car-rental/airport) | ## Frequently asked questions ### How much is a rental car per day in Santa Ana? ### What happens if I need to cancel my Santa Ana car reservation? ### Where can I go on a road trip from Santa Ana? > - Make your way to Colon for a fun-filled sightseeing experience. Around 35 miles from Santa Ana, it has tons of cool sights like Gatun Locks. > - Why not enjoy the best of Santiago too? Unmissable tourist attractions in this colorful city include Escuela Normal Juan Demostenes Arosemena. Santiago is around 110 miles from Santa Ana. > - Get into nature and appreciate the serenity at Starfish Beach. It's about 190 miles from Santa Ana. ### How do I find the best car rental deals in Santa Ana with Expedia? ### What do you need to rent a car in Santa Ana? ### What is the cheapest car rental in Santa Ana? ### Can I rent a car for a month or longer in Santa Ana? ### Where can I find a Santa Ana car rental if I am younger than 25? ### What insurance should I choose for my car rental in Santa Ana? ### Can I drive in Santa Ana with my current driver's license? > - Age restrictions: You need to be 25 or over in many countries to rent a car. If you're younger, it may still be possible to rent a car but you'll have to pay a Young Driver's Surcharge. Additional restrictions may also apply to the types of cars you can rent. > - Driving limitations: Make sure you read the rules and regulations before you drive away. You typically can't cross country borders, drive onto ferries or on off-road areas with a rental car. ## Explore a world of travel with Expedia - Lodging - Packages - Cars - [Hotels near Barrio Chino ](https://www.expedia.com/Barrio-Chino-Panama-City-Hotels.0-n714749931894550528-0.Travel-Guide-Filter-Hotels) - [Hotels near Avenida Central ](https://www.expedia.com/Avenida-Central-Hotels.0-l553248634285194371-0.Travel-Guide-Filter-Hotels) - [Hotels near Amador Theater ](https://www.expedia.com/Amador-Theater-Hotels.0-l553248621562725887-0.Travel-Guide-Filter-Hotels) - [Hotels near Danilo Perez Foundation ](https://www.expedia.com/Danilo-Perez-Foundation-Hotels.0-l553248621532965258-0.Travel-Guide-Filter-Hotels) - [Hotels near Iglesia de la Merced ](https://www.expedia.com/Iglesia-De-La-Merced-Hotels.0-l553248621562725896-0.Travel-Guide-Filter-Hotels) - [Hotels near Casco Viejo ](https://www.expedia.com/Casco-Viejo-Panama-City-Hotels.0-n6285189-0.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Casco Viejo ](https://www.expedia.com/Casco-Viejo-Panama-City-Hotels-Luxury-Hotel.0-n6285189-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - 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