Title: Top Independent in Dupo, IL - Expedia.com [Dupo Travel Guide](https://expedia.com/Dupo.dx6252511)[Hotels in Dupo](https://expedia.com/Dupo-Hotels.d6252511.Travel-Guide-Hotels)[Vacation Rentals in Dupo](https://expedia.com/Dupo-Vacation-Rentals.d6252511.Travel-Guide-VacationRentals)[Flights to Dupo](https://expedia.com/Cheap-Flights-To-Dupo.d6252511.Travel-Guide-Flights)[Car Rentals in Dupo](https://expedia.com/Car-Rentals-In-Dupo.d6252511.Car-Rental-Guide)[Dupo Vacation Packages](https://expedia.com/Dupo.d6252511.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 20 - Mar 21](https://www.expedia.com/Hotel-Search?regionId=6252511&startDate=2026-03-20&endDate=2026-03-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 21 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6252511&startDate=2026-03-21&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6252511&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6252511&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDupo-Hotels-Independent.0-0-d6252511--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDupo-Hotels-Independent.0-0-d6252511--bIndependent.Travel-Guide-Filter-Hotels) ## Top Dupo Hotel Reviews ![Clayton Plaza Hotel & Extended Stay](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/5c61cbf8_y.jpg) ### Clayton Plaza Hotel & Extended Stay 10/10 Excellent "Quick 1 night stay with my teenage daughter. It was perfect for what we needed. The lobby was beautiful and the parking garage was a nice touch!" [](https://expedia.com/St-Louis-Hotels-Clayton-Plaza-Hotel-Extended-Stay.h18144.Hotel-Information) ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/bd7064dc_y.jpg) ### 21C Museum Hotel St Louis 10/10 Excellent "It is a nice hotel" [](https://expedia.com/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information) ![Drury Inn & Suites St. Louis Union Station](https://images.trvl-media.com/lodging/1000000/40000/37700/37651/151222b4_y.jpg) ### Drury Inn & Suites St. Louis Union Station 10/10 Excellent "Wonderful, friendly staff, newly renovated room, great perks. Across the street from Union Station. Exceeded our expectations!" [](https://expedia.com/St-Louis-Hotels-Drury-Inn-St-Louis-At-Union-Station.h37651.Hotel-Information) ![Drury Plaza Hotel St. Louis at the Arch](https://images.trvl-media.com/lodging/1000000/550000/546300/546271/e43b9580_y.jpg) ### Drury Plaza Hotel St. Louis at the Arch 10/10 Excellent "The room was great with a view of the Arch...very comfortable. Very convenient location. The food buffets were good to have...average/above average. The drink tickets were appreciated. Staff was friendly." [](https://expedia.com/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-At-The-Arch.h546271.Hotel-Information) ![Pear Tree Inn St. Louis Near Union Station](https://images.trvl-media.com/lodging/1000000/30000/26600/26572/3056142b_y.jpg) ### Pear Tree Inn St. Louis Near Union Station 6/10 Okay "The hotel was nice and clean with good amenities of free breakfast and drinks each day. Parking was easy and free. It was super convenient and close to all the kids activities (City Museum, Arch, Zoo, etc). The blackout curtains in the room actually worked! We happened here during spring break when the weather was not great so the pool was insanely crowded and kind of gross (cloudy water and foamy hot tub). The pool water was also a bit chilly so not super enjoyable swimming which was a bummer bc that’s always a nice activity for the kids. I think had the hotel not been so busy we would have enjoyed our stay a bit more but it was good overall. " [](https://expedia.com/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Near-Union-Station.h26572.Hotel-Information) ![Hotel Indigo St Louis - Central West End by IHG](https://images.trvl-media.com/lodging/1000000/30000/22100/22068/bd89b9ce_y.jpg) ### Hotel Indigo St Louis - Central West End by IHG 8/10 Good "My room was clean and bathroom spacious. The manager sent a text to guests when a weather emergency occurred to let everyone know where to go and also followed up to make sure my stay was going well " [](https://expedia.com/St-Louis-Hotels-Holiday-Inn-Express-St-Louis-Central-West-End.h22068.Hotel-Information) ![River City Casino & Hotel](https://images.trvl-media.com/lodging/7000000/6460000/6456500/6456459/71580e9e_y.jpg) ### River City Casino & Hotel 10/10 Excellent "Great front desk assistance and nice facility with some non-smoking areas!" [](https://expedia.com/St-Louis-Hotels-River-City-Casino-Hotel.h6456459.Hotel-Information) ![Live by Loews - St.Louis](https://images.trvl-media.com/lodging/40000000/39170000/39161300/39161277/82c4c752_y.jpg) ### Live by Loews - St.Louis 10/10 Excellent "Clean room, helpful staff. Easy check-in and parking" [](https://expedia.com/St-Louis-Hotels-Live-By-Lowes-StLouis.h39161277.Hotel-Information) ![Best Western St. Louis-Kirkwood Route 66](https://images.trvl-media.com/lodging/1000000/10000/500/415/b788e069_y.jpg) ### Best Western St. Louis-Kirkwood Route 66 10/10 Excellent "Room was clean and staff was friendly and helpful. Would definitely stay again!" [](https://expedia.com/St-Louis-Hotels-Best-Western-Kirkwood-Inn.h415.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Wyndham Hotels in Cahokia ](https://www.expedia.com/Cahokia-East-St-Louis-Hotels-Wyndham-Hotels.0-n9361-0--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Cahokia ](https://www.expedia.com/Cahokia-East-St-Louis-Hotels-Motel-6.0-n9361-0--bMotel6.Travel-Guide-Filter-Hotels) - [Drury Inn & Suites Hotels in Cahokia ](https://www.expedia.com/Cahokia-East-St-Louis-Hotels-Drury-Inn-Suites.0-n9361-0--bDruryInnSuites.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Cahokia ](https://www.expedia.com/Cahokia-East-St-Louis-Hotels-Cheap-Hotels.0-n9361-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Cahokia ](https://www.expedia.com/Cahokia-East-St-Louis-Hotels-Hotels-With-Indoor-Pool.0-n9361-0-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Hotels near Cahokia ](https://www.expedia.com/Cahokia-East-St-Louis-Hotels.0-n9361-0.Travel-Guide-Filter-Hotels) - 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