Eastern Panama Vacations from $629

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites
Hotel Riu Plaza Panama
Megapolis Hotel Panamá
Villa Botero By Casa Mojito B&B
Villa Marina Lodge & Condos
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Discover the most popular places to visit in Eastern Panama

Eastern Panama Hotel Deals

HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $112 total per night from Feb 4 to Feb 5
$112 total
Feb 4 - Feb 5
Total with taxes and fees
4.8/10 (5 reviews)
Although I gave this hotel a medium rating I enjoyed myself. This is a rough almost close to camping hotel. I must have not seen the message about bringing soap wash clothes, hand towel, tissue actually everything. The water does not get cold and there was a party set up just outside the window lasting ...

Reviewed on Sep 19, 2025

HOTEL ISLA GRANDE
Hotel Cocotal

Hotel Cocotal

2.5 out of 5
La Guaira Isla Grande Provincia de Colón
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $112 total per night from Feb 4 to Feb 5
$112 total
Feb 4 - Feb 5
Total with taxes and fees
9.4/10 Exceptional! (6 reviews)
Excelente hospedaje lo mejor la amabilidad de José Ángel y los demás muchachos... Con decirles que hasta te llevan a la habitación si te has tomado algunos tragos.. recomendada al 100

Reviewed on Jan 7, 2026

Hotel Cocotal
Konsenda San Blas

Konsenda San Blas

2 out of 5
Llano Cartí Km 11 El Llano Panamá Province
Fully refundableReserve now, pay when you stay
$42 nightly
The price is $47 total per night from Mar 5 to Mar 6
$47 total
Mar 5 - Mar 6
Total with taxes and fees
10/10 Exceptional! (1 review)
wonderful eco lodge in the forest. Easy to reach by car, just on the main road. Paths to walk, excellent meals. A very good option if you need to relax before and after visiting Sab Blas, but worth the trip on its own, beautiful landscape.

Reviewed on Mar 6, 2025

Konsenda San Blas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Eastern Panama Vacation Packages

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.