Name: San Blas Paradise Private Cabins on Shipwreck Island - meals included
Price range: $186 total

Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.

Hotel Riu Plaza Panama

Bella Vista

$808

per person

Nov 21 - Nov 28

found 1 day ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

9/10 Wonderful! (4,232 reviews)

Our room was comfortable and clean. Our breakfast was very good and staff attentive to my husband who has special needs.

Reviewed on Sep 17, 2025

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

$980

per person

Dec 5 - Dec 12

found 16 hours ago

Roundtrip flight included

Bridgetown (BGI) to Panama City (PTY)

9/10 Wonderful! (986 reviews)

The jacuzzi in the room was terrible. Many, many times I tried but could not get it to work. Maintenance came multiple times, but they too had a hard time getting it to work.

Reviewed on Sep 9, 2025

Central Hotel Bocas del Toro

Save 100% on your flight

$2,010

per person

Nov 26 - Dec 3

found 20 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

No reviews

The Sands by Wynwood House

Calidonia

Save 100% on your flight

$2,171

per person

Oct 21 - Oct 26

found 1 day ago

Roundtrip flight included

Port of Spain (POS) to Panama City (PTY)

No reviews

La Coralina Island House

Save 100% on your flight

$1,420

per person

Nov 26 - Dec 3

found 20 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9.4/10 Exceptional! (85 reviews)

2nd time visiting. Love!!

Reviewed on Sep 16, 2025

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Discover the most popular places to visit in Eastern Panama

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

Eastern Panama Hotel Deals

Ciel y Miel

Caillle Principale, Cacique, Provincia de Colón

$320 nightly

$352 total

Sep 25 - Sep 26

Total with taxes and fees

10/10 Exceptional! (9 reviews)

"All was good"

Reviewed on Jul 14, 2025

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

10/10 Exceptional! (3 reviews)

"Amazing piece of Caribbean paradise! The staff went above and beyond to make us feel special."

Reviewed on Sep 5, 2025

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San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

$169 nightly

$186 total

Sep 20 - Sep 21

Total with taxes and fees

See all 171 properties in Eastern Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.