Eastern Panama Vacations from $553

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites
Central Hotel Panama Casco Viejo
Villa Botero By Casa Mojito B&B
Hotel Riu Plaza Panama
Megapolis Hotel Panamá
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Discover the most popular places to visit in Eastern Panama

Eastern Panama Hotel Deals

HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
4.8/10 (8 reviews)
This hotel is very run down, and should not be $150/night. Did not have access to running water in our room. Location and beach are its saving graces.

Reviewed on Feb 4, 2026

HOTEL ISLA GRANDE
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
$188 nightly
The price is $207 total per night from Mar 21 to Mar 22
$207 total
Mar 21 - Mar 22
Total with taxes and fees
10/10 Exceptional! (1 review)
Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door.

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
Hotel Cocotal

Hotel Cocotal

2.5 out of 5
La Guaira Isla Grande Provincia de Colón
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $107 total per night from Mar 29 to Mar 30
$107 total
Mar 29 - Mar 30
Total with taxes and fees
Hotel Cocotal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Eastern Panama Vacation Packages

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.