Eastern Panama Vacations from $438

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Room in Guest Room - Room in Comfortable Apartment Located on the Beach Very Close to the City

Room in Guest Room - Room in Comfortable Apartment Located on the Beach Very Close to the City

3 out of 5
per person
Jul 6 - Jul 11
found 24 hours ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
No reviews
Residencia Natural

Residencia Natural

3 out of 5
per person
Jul 20 - Jul 27
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
10/10 Exceptional! (6 reviews)
Hotel República

Hotel República

2 out of 5
Santa Ana
per person
Jul 15 - Jul 22
found 5 hours ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
6.6/10 (164 reviews)
The wifi is strong enough to use for work.

Reviewed on Apr 16, 2025

Casa Bianca

Casa Bianca

2 out of 5
Bella Vista
per person
Jul 15 - Jul 22
found 5 hours ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
10/10 Exceptional! (2 reviews)
Very spacious and well kept. Close to everything and easy access to public transportation. Supermarket is across the street. You’re close to everything. Also, a high traffic area and lots of city noise. I enjoyed the stay.

Reviewed on Apr 11, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
per person
Jun 9 - Jun 12
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
9/10 Wonderful! (863 reviews)
Very nice hotel! Staff is very friendly

Reviewed on Apr 29, 2025

Find the Best Eastern Panama Vacation Packages

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

Ready to book your vacation to Eastern Panama?

 

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Eastern Panama Hotel Deals

Ordovician Beach Resort
Ordovician Beach Resort
4.5 out of 5
Isla Grande, Isla Grande, Colon
The price is $594 per night from May 14 to May 15
$594
includes taxes & fees
$540 per night
May 14 - May 15
Ordovician Beach Resort
Ciel y Miel
Ciel y Miel
3 out of 5
Caillle Principale, Cacique, Provincia de Colón
The price is $253 per night from May 1 to May 2
$253
includes taxes & fees
$230 per night
May 1 - May 2
10/10 Exceptional! (4 reviews)
"Is an execelent place to relax, enjoy nice food and view. It has access to a beautiful beach which is not overcrowded and the staff is on top of everything. Me and my family are definetly coming back!!!"

Reviewed on Mar 3, 2025

Ciel y Miel
Private Over the Water Cabin on San Blas Island
Private Over the Water Cabin on San Blas Island
2 out of 5
9.542876, -78.899058, Narganá, San Blas
The price is $230 per night from May 1 to May 2
$230
includes taxes & fees
$209 per night
May 1 - May 2
6.4/10 (5 reviews)
"Communication was good and highly organized. We felt safe and didn’t need to lock up our bags or valuables at all times. Weather was rough (not their fault) so the stay was a challenge with super high winds and rain. The island was covered in trash nearly all the way around. Our cabin doors were ..."

Reviewed on Feb 16, 2022

Private Over the Water Cabin on San Blas Island
See all 159 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Eastern Panama

Cayos Holandeses

Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.

Cayos Holandeses

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Museum of the Kuna Nation

Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

Porvenir Museum

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.