Eastern Panama Vacations from $646

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel San Pedro de Taboga

Hotel San Pedro de Taboga

3 out of 5
Price was $984, price is now $646 per person
$646
per person
Dec 24 - Dec 29
found 13 hours ago
Roundtrip flight included
Georgetown (GEO) to Panama City (PTY)
9.6/10 Exceptional! (5 reviews)
Peronal muy amable y dispuestos ayudar en todo momento.

Reviewed on Sep 21, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $4,365, price is now $2,157 per person
$2,157
per person
Dec 25 - Dec 31
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,015 reviews)
In the heart of Casco Viejo, the first hotel built but you could not tell as it has been remodeled. A lot of history. The place is beautiful and well maintained. We went on a sailing trip for 2 days and the held our bags at no extra cost. The staff is great and the restaurant in the back is absolutely delicious! Lots of great restaurants around as well. There is a Speakeasy nearby called Villa Ana 1928, second floor above the restaurant, don’t miss it!

Reviewed on Nov 5, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $1,864, price is now $1,067 per person
$1,067
per person
Jan 26 - Jan 31
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,803 reviews)
Shops nearby

Reviewed on Nov 6, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Tocumen Airport
Price was $1,449, price is now $957 per person
$957
per person
Jan 26 - Jan 31
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,824 reviews)

Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was $1,959, price is now $1,330 per person
$1,330
per person
Jan 26 - Jan 31
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.6/10 Exceptional! (482 reviews)

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Stay near popular Eastern Panama attractions

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.
See properties

Eastern Panama Hotel Deals

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
$427 nightly
The price is $473 total per night from Nov 8 to Nov 9
$473 total
Nov 8 - Nov 9
Total with taxes and fees
10/10 Exceptional! (16 reviews)
"The best place in the world to have a relax and amazing vacation."

Reviewed on Nov 5, 2026

Ordovician Beach Resort
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
$188 nightly
The price is $207 total per night from Nov 7 to Nov 8
$207 total
Nov 7 - Nov 8
Total with taxes and fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
san blas luxury tour

san blas luxury tour

2 out of 5
guna yala Nusatupo Guna Yala
$111 nightly
The price is $122 total per night from Nov 7 to Nov 8
$122 total
Nov 7 - Nov 8
Total with taxes and fees
san blas luxury tour
See all 197 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Eastern Panama Vacation Packages

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

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Frequently asked questions

What's included in an Eastern Panama vacation package?
An Eastern Panama vacation package in Isla Grande lets you combine flights, hotel stays, and rental cars. Your flight will typically arrive at Panama City (PTY-Tocumen Intl.) Airport. For hotels with available data in Isla Grande, nearly all offer free breakfast, providing a convenient start to your day.

Exactly what's included will vary by hotel and package, so it's worth reviewing the details before you confirm your booking.
How can I save money on a Eastern Panama vacation package?
When you bundle, you can save up to 30%*. To save money on a Eastern Panama package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
Which destinations should I consider for an Eastern Panama vacation?
For an Eastern Panama vacation, choosing the right base depends on your travel style. Here are some top destinations to consider:
  • Narganá: This area is ideal for travelers seeking beach-focused outdoor activities and scenic views, offering the most lodging choices in the region.
  • San Blas Islands: Perfect for families and eco-conscious travelers, these islands are known for their beautiful beaches and opportunities for outdoor adventures.
  • Isla Grande: Another excellent option for those prioritizing beach experiences, outdoor activities, and eco-friendly travel, with a good range of places to stay.
  • Carti: If your Eastern Panama vacation package emphasizes family-friendly attractions, Carti provides a great base alongside its outdoor and eco-travel offerings.
Is Eastern Panama better suited for a beach vacation or a cultural trip?
Eastern Panama is primarily an outdoor and nature destination, known for its diverse landscapes and eco-friendly travel opportunities. Many areas, such as Narganá and the San Blas Islands, are characterized by beautiful beaches, making it an excellent choice for a beach vacation with activities like exploring islands such as Isla Diablo.

While beaches and outdoor adventures are a major draw, Eastern Panama also offers cultural insights. You can visit the Museum of the Kuna Nation to learn about indigenous heritage or explore historical sites like Portobelo National Park, which blends natural beauty with colonial history.

Ultimately, an Eastern Panama vacation package suits travelers seeking a blend of natural exploration, beach relaxation, and cultural discovery, with a strong emphasis on outdoor activities.
Which airport should I use for an Eastern Panama vacation?
For an Eastern Panama vacation, the primary international gateways are Panama City (PTY-Tocumen Intl.) and Panama City (PAC-Marcos A. Gelabert Intl.). These airports serve Panama City, which acts as the main access point for the wider Eastern Panama region.

Depending on your specific destination within Eastern Panama, smaller regional airports like Ustupu-Ogobsucum Airport (OGM) or Contadora Island (OTD) might offer closer proximity to your final stay.
What are the top things to do in Eastern Panama?
An Eastern Panama vacation is best explored from a base like Narganá, which offers the most lodging choices in the region. From there, you can discover a variety of attractions:

Browse and book things to do in Eastern Panama on Expedia.
Can I change or cancel my Eastern Panama vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Eastern Panama vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Eastern Panama vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Eastern Panama vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Eastern Panama?
To find last-minute vacation packages to Eastern Panama, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Eastern Panama vacation packages?
Free cancellation on a Eastern Panama vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Eastern Panama vacation as a package or separately?
An Expedia vacation package could land you great savings when compared to arranging flights and hotels separately. Better still, you can tailor your Eastern Panama getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Eastern Panama vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.