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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.

Hotel Riu Plaza Panama

Bella Vista

per person

Sep 19 - Sep 24

found 2 days ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

9/10 Wonderful! (4,078 reviews)

Beautiful stay, the room was great and the food was excellent. Definitely will stay there again

Reviewed on Jul 30, 2025

La Coralina Island House

Save 100% on your flight

per person

Sep 15 - Sep 20

found 21 hours ago

Roundtrip flight included

New York (JFK) to Panama City (PTY)

9.4/10 Exceptional! (82 reviews)

Wow! This resort is absolutely amazing! Bekar went above and beyond for us! He even brought in a TV to the lobby so we could watch the NHL playoff game! Food is 10/10 as well. We will definitely go back!

Reviewed on May 18, 2025

Central Hotel Bocas del Toro

Save 100% on your flight

per person

Sep 15 - Sep 20

found 21 hours ago

Roundtrip flight included

New York (JFK) to Panama City (PTY)

No reviews

Coral Bay Bungalows

Save 100% on your flight

per person

Sep 15 - Sep 20

found 21 hours ago

Roundtrip flight included

New York (JFK) to Panama City (PTY)

No reviews

NAYARA Bocas del Toro

Save 100% on your flight

per person

Sep 15 - Sep 20

found 21 hours ago

Roundtrip flight included

New York (JFK) to Panama City (PTY)

10/10 Exceptional! (52 reviews)

Very quiet and isolated, Far from the maddening crowd. Fantastic service, great food.

Reviewed on Mar 5, 2025

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Discover the most popular places to visit in Eastern Panama

Cayos Holandeses

Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

Eastern Panama Hotel Deals

Ranchos de Chalia

Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón

$140 nightly

$153 total

Aug 6 - Aug 7

Total includes taxes and fees

9.6/10 Exceptional! (4 reviews)

"Such a beautiful place! Lovely view and very close to access to the beach. 5 min small boats ride. Relaxing environment mixing mountain feeling and beach view. Very cozy for family of 2 kids. The people in charge there are exceptional!"

Reviewed on Apr 19, 2025

Ordovician Beach Resort

Isla Grande, Isla Grande, Colon

10/10 Exceptional! (2 reviews)

"The Ordovician Hotel is a hidden gem on the peaceful west side of Isla Grande. From the moment we booked, the service was personal and seamless—thank you, Yohan! We were welcomed by name, greeted with a delicious tropical drink, and felt like cherished guests from start to finish. We stayed in the ..."

Reviewed on Jul 25, 2025

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Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island, Narganá, Guna Yala

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See all 168 properties in Eastern Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.