Name: HOTEL ISLA GRANDE
Price range: $118 total

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.

La Cuadra by Wynwood House

El Chorrillo

$636

per person

Jun 12 - Jun 18

found 1 day ago

Roundtrip flight included

Georgetown (GEO) to Panama City (PTY)

9/10 Wonderful! (52 reviews)

Second stay here and just as perfect as our first stay.

Reviewed on Mar 4, 2026

Casa Mallet by Wynwood House

Casco Viejo

$1,293

per person

Jul 25 - Aug 1

found 4 hours ago

Roundtrip flight included

Kingston (KIN) to Panama City (PTY)

9.8/10 Exceptional! (27 reviews)

In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026

Villa Caprichosa

$735

per person

Jul 16 - Jul 21

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

9.8/10 Exceptional! (66 reviews)

What a beautiful place! A dream come true.

Reviewed on Apr 16, 2026

Mini Design By Wynwood House

Bella Vista

$680

per person

Jun 12 - Jun 18

found 1 day ago

Roundtrip flight included

Georgetown (GEO) to Panama City (PTY)

10/10 Exceptional! (2 reviews)

Central Hotel Panama Casco Viejo

Casco Viejo

$1,022

per person

Jul 18 - Jul 21

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9.2/10 Wonderful! (1,005 reviews)

Excelente localización personal del hotel muy bueno. La crítica.: hotel no te tiene los útiles básicos como crema para la piel, gorro de baño. Cepillo dental etc. Hay q estar en la recepción para recordar y solicitarlo

Reviewed on May 4, 2026

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Discover the most popular places to visit in Eastern Panama

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.

Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

Eastern Panama Hotel Deals

Ciel y Miel

Caillle Principale Cacique Provincia de Colón

$207 nightly

$228 total

May 12 - May 13

Total with taxes and fees

10/10 Exceptional! (10 reviews)

The views from this mountain-top boutique hotel are extraordinary.

Reviewed on Feb 1, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island Narganá Guna Yala

10/10 Exceptional! (1 review)

Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door.

Reviewed on Mar 15, 2026

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HOTEL ISLA GRANDE

Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province

$107 nightly

$118 total

May 14 - May 15

Total with taxes and fees

See all 180 properties in Eastern Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.