Eastern Panama Vacations from $629
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Your Eastern Panama Vacation
Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.
The Latest Eastern Panama vacation packages
Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá
San Francisco
Save 100% on your flight
Price was $1,338, price is now $895 per person
$895
per person
Mar 19 - Mar 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
8.4/10 Very Good! (1,204 reviews)
Excellent service, large rooms and very clean
Reviewed on Jan 28, 2026
Villa Botero By Casa Mojito B&B
Price was $1,115, price is now $776 per person
$776
per person
Apr 23 - Apr 28
found 17 hours ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
We stayed one night and it exceeded our expectations. The owners were incredibly friendly and easy to contact, making us feel right at home. Everything was spotless, and the atmosphere was warm and inviting. The homemade breakfast was a highlight—absolutely delicious and full of flavor. We will stay again longer next time.
Reviewed on Jan 22, 2026
Villa Marina Lodge & Condos
Price was $988, price is now $693 per person
$693
per person
Apr 13 - Apr 18
found 14 hours ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
9/10 Wonderful! (133 reviews)
Love that this property is at the other end of the beach from the late night partying. Walkable beach. Great restaurants nearby. The property was adding coffee makers and mini fridges the day we were leaving. Great staff, restaurant and drinks. We’ve been twice with our pooches. Will be back
Reviewed on Jul 14, 2025
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See all available trips from Columbus to Eastern Panama
View all tripsDiscover the most popular places to visit in Eastern Panama
Museum of the Kuna Nation
You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.
Porvenir Museum
You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.
Eastern Panama Hotel Deals
HOTEL ISLA GRANDE
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $112 total per night from Feb 4 to Feb 5
$112 total
Feb 4 - Feb 5
Total with taxes and fees
4.8/10 (5 reviews)
Although I gave this hotel a medium rating I enjoyed myself. This is a rough almost close to camping hotel. I must have not seen the message about bringing soap wash clothes, hand towel, tissue actually everything. The water does not get cold and there was a party set up just outside the window lasting ...
Reviewed on Sep 19, 2025
Hotel Cocotal
La Guaira Isla Grande Provincia de Colón
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $112 total per night from Feb 4 to Feb 5
$112 total
Feb 4 - Feb 5
Total with taxes and fees
9.4/10 Exceptional! (6 reviews)
Excelente hospedaje lo mejor la amabilidad de José Ángel y los demás muchachos... Con decirles que hasta te llevan a la habitación si te has tomado algunos tragos.. recomendada al 100
Reviewed on Jan 7, 2026
Konsenda San Blas
Llano Cartí Km 11 El Llano Panamá Province
Fully refundableReserve now, pay when you stay
$42 nightly
The price is $47 total per night from Mar 5 to Mar 6
$47 total
Mar 5 - Mar 6
Total with taxes and fees
10/10 Exceptional! (1 review)
wonderful eco lodge in the forest. Easy to reach by car, just on the main road. Paths to walk, excellent meals. A very good option if you need to relax before and after visiting Sab Blas, but worth the trip on its own, beautiful landscape.
Reviewed on Mar 6, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Eastern Panama Vacation Packages
Eastern Panama Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Tocumen Intl. Airport (PTY) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
