Eastern Panama

Travel Guide

50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. #BVSBlue
50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. #BVSBlue
A Kuna Yala man headed out to fish. If you have ever dreamed of spending a night or two on a small, private island, check out Kuna Yala. If you don't like roughing it a little bit, this might not be for you. There are cabins with flushing toilets but no electricity and the shower water is rather cool. Great place to get away from crowds and unplug though. #islands #peaceful #Adventure #water #ocean #boat #trovember
A definite bucketlist place to visit if ever in #Panama. #SanBlas
Secluded island in the Guna Yala region of Panama

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Hotel Cocotal

Hotel Cocotal

2.5 out of 5
La Guaira Isla Grande Provincia de Colón
$97 nightly
The price is $107 total per night from Mar 16 to Mar 17
$107 total
Mar 16 - Mar 17
Total with taxes and fees
Stay at this hotel in Isla Grande. Enjoy free breakfast, free WiFi, and 20 restaurants. Popular attractions Isla Mamey and Portobelo National Park are located ...
Hotel Cocotal
Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
$423 nightly
The price is $473 total per night from Apr 11 to Apr 12
$473 total
Apr 11 - Apr 12
Total with taxes and fees
Book a stay at this luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park ...
10/10 Exceptional! (9 reviews)
The resort was outstanding. It exceeded expectations in every way. The service was the best we had in Panama. The cocktails were fun and the food was delicious and they have a vegan menu. We stayed in a king room and it was very private, pristine and well appointed.

Reviewed on Feb 21, 2026

Ordovician Beach Resort
HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
Book a stay at this beach hotel in Isla Grande. Enjoy free breakfast, a beach locale, and onsite spa services. Popular attractions Isla Mamey and Portobelo National ...
4.8/10 (8 reviews)
This hotel is very run down, and should not be $150/night. Did not have access to running water in our room. Location and beach are its saving graces.

Reviewed on Feb 4, 2026

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HOTEL ISLA GRANDE
See all 175 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
San Blas Private Beach Cabin

San Blas Private Beach Cabin

2.5 out of 5
Nusatupo Narganá Guna Yala
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ...
San Blas Private Beach Cabin
San Blas Private Oceanfront Cabin

San Blas Private Oceanfront Cabin

2.5 out of 5
C5W9 4M Nusatupo Narganá Guna Yala
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge).
San Blas Private Oceanfront Cabin
Private Over-Water Cabins on San Blas Island

Private Over-Water Cabins on San Blas Island

2.5 out of 5
C5W9 4M Nusatupo Narganá
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ...
Private Over-Water Cabins on San Blas Island
See all properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Secluded island in the Guna Yala region of Panama

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.

Isla Diablo

Isla Chichime

Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area.

Isla Chichime

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.

Museum of the Kuna Nation

Cities near Eastern Panama

Islands of San Blas , Panama; Shutterstock ID 687617053; Purchase Order: -

San Blas Islands

Isla Grande Panama Tropen Strand

Isla Grande

#lifeatexpedia Beautiful Portobelo is full of history and culture. Located on the Caribbean coast it has a variety of world class attractions. The historic town of Portobelo is one of the most scenic spots in Panama. Set on a turquoise Caribbean bay, it was Spanish Empires' s trade epicenter in the 16th and 17th century. Don´t miss the Portobello Fortress and the Cristo Negro Church!

Portobelo

Scenic Coiba Island Aerial View

Santa Isabel