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A nighttime view of a lake with reflections of Christmas lights and trees.

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    Check prices for these dates, December 14 – 15, 2026

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    Our top choices for Florence guest houses

    1. Empire House Hotel

    An aerial view of a waterfront area with a prominent circular structure featuring the inscription "SUN" and "SUN" on its roof.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Learn more about Florence

    Swing by the iconic 'Florence Y'all' water tower before exploring the city's antique treasures at Florence Antique Mall. Tee off at World of Golf or catch a thrilling game at UC Health Stadium for a perfect blend of leisure and excitement.

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    A nighttime view of a lake with reflections of Christmas lights and trees.

    Frequently Asked Questions

    What is the nightly rate for a guest house in Florence?

    Rates for Florence guest houses vary, but travelers can find great-value prices from $68 with Expedia. A range of factors can affect nightly rates, such as the location, the breakfast offering, and the range of amenities. Travelers looking for a good deal should consider looking for a midweek stay, as weekend rates at Florence guest houses tend to be higher. Remember to also use our filters to sort prices from low to high.

    What's the difference between a Florence guest house and a B&B?

    A guest house in Florence is typically a larger establishment with more rooms, offering a more hotel-like experience, and may provide additional amenities including luxury bedding. In contrast, a B&B is usually a smaller property that focuses primarily on providing a room and breakfast. A B&B is often more personal, and breakfast is typically included as part of the stay, but other services might be more limited compared to a guest house.

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