Guadalupe Vacations from $756

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Guadalupe Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Jan 11 - Jan 17

    Hotel San Pedro de Taboga + Flight

    Taboga
    6 nights
    3.0 star property
    9.6/10 - Exceptional (5 reviews)
    "Peronal muy amable y dispuestos ayudar en todo momento."
    Reviewed September 21, 2026
    Roundtrip • Kingston (KIN) - Panama City (PTY)
    KIN - PTY • Nonstop PTY - KIN • Nonstop
    $1,089
    $756
    per traveler
    found 16 hours ago
    Hotel San Pedro de Taboga
  • Dec 7 - Dec 13

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    6 nights
    4.0 star property
    9.2/10 - Wonderful (1,006 reviews)
    "Beautiful historic hotel with very clean rooms and great wifi. Mini fridge, safe, bathrobes. Free welcome drink. Perfect location!"
    Reviewed November 6, 2026
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    $2,618
    $1,322
    per traveler
    found 1 day ago
    Central Hotel Panama Casco Viejo
  • Dec 7 - Dec 13

    Megapolis Hotel Panamá + Flight

    San Francisco
    6 nights
    4.5 star property
    8.6/10 - Excellent (1,845 reviews)
    "The saying "you get what you pay for", applies to this hotel. The room that I initially checked in, the bathroom vent was buzzing. I called to have it fixed. I used the bathroom as I waited. When I flushed the toilet; it overflowed. I changed rooms the next day. Had the same issue with the vent. The bathroom sink was clogged. The phone didn't work when I tried placing an order for room service; therefore, at 11:30 pm, I had to go to the lobby to order. Everything closes by 8pm (too early). Not..."
    Reviewed November 6, 2026
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    $2,308
    $1,199
    per traveler
    found 1 day ago
    Megapolis Hotel Panamá
  • Dec 7 - Dec 13

    Riande Aeropuerto Hotel & Casino + Flight

    Tocumen Airport
    6 nights
    4.0 star property
    8.6/10 - Excellent (1,814 reviews)
    "Clean, convenient, good food"
    Reviewed November 6, 2026
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    $1,511
    $989
    per traveler
    found 1 day ago
    Riande Aeropuerto Hotel & Casino
  • Dec 7 - Dec 13

    Hyatt Regency Panama City + Flight

    Bella Vista
    6 nights
    5.0 star property
    9.6/10 - Exceptional (501 reviews)
    Roundtrip • New York (EWR) - Panama City (PTY)
    JFK - PTY • Nonstop PTY - JFK • Nonstop
    $1,881
    $1,323
    per traveler
    found 1 day ago
    Hyatt Regency Panama City

Guadalupe Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

Is Guadalupe better suited for a beach vacation or a cultural trip?

Guadalupe is primarily a beach destination, making it well-suited for a relaxing coastal getaway. Its beautiful shores are the main draw for a Guadalupe vacation, offering opportunities for sunbathing and water activities.


As a central urban destination, Guadalupe also provides convenient access to city amenities, dining, and local experiences, blending beach relaxation with urban convenience for your Guadalupe vacation package.

Can I change or cancel my Guadalupe vacation package if my plans change?

Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.

Do One Key members get extra savings when booking Guadalupe vacation packages?

Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.

Does Expedia offer Book Now, Pay Later Guadalupe vacation packages?

Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Guadalupe vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.

How can I save money on a Guadalupe vacation package?

When you bundle, you can save up to 30%*. To save money on a Guadalupe package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.

How do I find last-minute vacation packages to Guadalupe?

To find last-minute vacation packages to Guadalupe, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.

How does free cancellation work on Guadalupe vacation packages?

Free cancellation on a Guadalupe vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.

Is it cheaper to book a Guadalupe vacation as a package or separately?

Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Guadalupe getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.

Why should I book my Guadalupe vacation package with Expedia?

Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.