A densely packed urban area with numerous buildings and a prominent tower on a hill.

Puerto Santa Ana Vacations from $255

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Your Puerto Santa Ana Vacation

With plenty of highlights as well as some hidden gems, this city is best experienced with a Puerto Santa Ana vacation package. Find somewhere to stay in Downtown Guayaquil, which is good for views, culture and history. Malecon 2000, Banco Pichincha Monumental Stadium and Mall del Sol Commercial Center are just a few of the many attractions you'll want to see during your trip to Puerto Santa Ana. Whoever you're taking time off with and whatever you plan to spend, your ultimate Puerto Santa Ana vacation is just a few clicks away with Expedia.

The Latest Puerto Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A spacious indoor dining area with multiple tables and chairs, surrounded by potted plants and featuring a central decorative fountain.
    Jan 11 - Jan 13

    Hotel Boutique Santa Lucia + Flight

    Downtown Cuenca
    2 nights
    4.0 star property
    9.2/10 - Wonderful (413 reviews)
    "Great place"
    Reviewed October 28, 2026
    Roundtrip • Quito (UIO) - Guayaquil (GYE)
    UIO - GYE • Nonstop GYE - UIO • Nonstop
    $338
    $255
    per traveler
    found 1 day ago
    Hotel Boutique Santa Lucia
  • A modern living room with a large window overlooking a coastal landscape, a built-in pool, and a seating area with a coffee table.
    Dec 26 - Dec 30

    Eolia Sustainable Design Hotel + Flight

    Manta
    4 nights
    4.0 star property
    9.2/10 - Wonderful (15 reviews)
    "Un hotei muy bonito con muy mal servicio"
    Reviewed November 2, 2026
    Roundtrip • Quito (UIO) - Guayaquil (GYE)
    UIO - GYE • Nonstop GYE - UIO • Nonstop
    $822
    $467
    per traveler
    found 1 day ago
    Eolia Sustainable Design Hotel
  • A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.
    Jan 19 - Jan 21

    Hotel Río Guayas by Art Hotels Ecuador + Flight

    Las Peñas
    2 nights
    4.0 star property
    10/10 - Exceptional (6 reviews)
    Roundtrip • Chicago (CHI) - Guayaquil (GYE)
    ORD - GYE • 1 stop GYE - ORD • 1 stop
    $1,095
    $805
    per traveler
    found 13 hours ago
    Hotel Río Guayas by Art Hotels Ecuador
  • A hotel room with two beds, each with a different patterned bedspread. There is a nightstand with a lamp and a small potted plant.
    Dec 23 - Dec 29

    Hospedaje Casa Aida Victoria + Flight

    Downtown Cuenca
    5 nights
    1.0 star property
    Roundtrip • New York (EWR) - Guayaquil (GYE)
    EWR - CUE • 2 stops CUE - EWR • 2 stops
    $32,999
    $24,862
    per traveler
    found 17 hours ago
    Hospedaje Casa Aida Victoria
  • A courtyard with a fountain, seating area, and a building with a dome and clock tower.
    Jan 19 - Jan 21

    Hotel del Parque + Flight

    Samborondon
    2 nights
    4.5 star property
    9.8/10 - Exceptional (141 reviews)
    "La propiedad es increible la seguridad el staff del hotel 10/10 las instalaciones de primera recomendado 100%"
    Reviewed October 8, 2026
    Roundtrip • Chicago (CHI) - Guayaquil (GYE)
    ORD - GYE • 1 stop GYE - ORD • 1 stop
    $1,115
    $894
    per traveler
    found 13 hours ago
    Hotel del Parque

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Puerto Santa Ana
Learn more about Puerto Santa Ana
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Discover the most popular places to visit in Puerto Santa Ana

Emporium by The Point

After visiting Emporium by The Point, make a plan to see the other sights and activities in Guayaquil. Attend a sporting event in this walkable area, or simply enjoy its restaurants.
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What to do near Puerto Santa Ana

City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

$65
per adult
100% of travelers recommend
Wine Tasting Experience with Tasting Menu
See all activities near Puerto Santa Ana

Puerto Santa Ana Hotel Deals

A modern bar area with a bar counter, seating, and a large window.

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,010 reviews)
"Todo estuvo muy bien"
$108 nightly
The price is $121
Nov 15 - Nov 16
Wyndham Guayaquil Puerto Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.