The best area to stay in Salome, Arizona, is near the town center, particularly along U.S. Route 10, which serves as the main thoroughfare.This central area offers the most convenience for visitors, with lodging options, local eateries, and essential services concentrated within a short distance. It's a practical choice for solo travelers or couples looking for straightforward access to amenities and a good base for exploring the surrounding desert landscape.For those requiring easy access to recreational activities, staying near the west end of town, closer to the desert and open spaces, is ideal.