A coastal city with a historic fort featuring cannons, a modern skyline, and a clear blue sky.

Santa Clara Vacations from $997

Book a Hotel + Flight or Car together to unlock savings

Your Santa Clara Vacation

Santa Clara is calling! Whatever type of escape you have in mind, you can discover more of this neighborhood with a Santa Clara vacation package. Not sure what to see and do during your trip to Santa Clara? Nearby attractions like Jaime Moron Stadium, Mercado Bazurto and Promenade of La Castellana are great places to start. Stop daydreaming and start doing. When it's time to lock in your next vacation to Santa Clara, Expedia will help you get there.

The Latest Santa Clara Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A modern interior with a dining area, kitchen, and seating space.
    Feb 1 - Feb 6

    Casa Bali Castillo View Private Pool & R + Flight

    Pie del Cerro
    5 nights
    3.5 star property
    10/10 - Exceptional (1 review)
    "Excelente ubicación, buenas instalaciones, en la recepción tanto Omar como la recepcionista fueron muy amables en todo momento."
    Reviewed February 17, 2026
    Roundtrip • New York (NYC) - Cartagena (CTG)
    JFK - CTG • Nonstop CTG - JFK • 1 stop
    $2,292
    $997
    per traveler
    found 18 hours ago
    Casa Bali Castillo View Private Pool & R
  • A courtyard with wicker furniture, potted plants, and a fruit bowl.
    Jan 22 - Jan 26

    Luxury Apartment– Private Pool & Rooftop Jacuzzi + Flight

    Cartagena Walled City
    4 nights
    3.5 star property
    Roundtrip • New York (NYC) - Cartagena (CTG)
    JFK - CTG • Nonstop CTG - JFK • Nonstop
    $3,450
    $1,455
    per traveler
    found 7 hours ago
    Luxury Apartment– Private Pool & Rooftop Jacuzzi
  • A balcony with a hammock, a small round table with a plate of grapes and two wine glasses, and a view of historic buildings.
    Jan 14 - Jan 19

    La Muralla Rooftop Duplex Jacuzzi & View + Flight

    Cartagena Walled City
    5 nights
    3.5 star property
    Roundtrip • New York (EWR) - Cartagena (CTG)
    JFK - CTG • 1 stop CTG - JFK • 1 stop
    $2,602
    $1,205
    per traveler
    found 1 day ago
    La Muralla Rooftop Duplex Jacuzzi & View
  • A pool area with a spiral staircase, lounge chairs, and potted plants.
    Dec 17 - Dec 22

    Casa Pestagua Relais Châteaux + Flight

    Cartagena Walled City
    5 nights
    4.5 star property
    9.6/10 - Exceptional (300 reviews)
    Roundtrip • New York (EWR) - Cartagena (CTG)
    EWR - CTG • 1 stop CTG - EWR • 1 stop
    $5,266
    $2,688
    per traveler
    found 1 day ago
    Casa Pestagua Relais Châteaux
  • A wooden deck with a canopy bed overlooking a beach.
    Jan 29 - Feb 1

    Decameron Barú, A Trademark All Inclusive + Flight

    Cartagena
    3 nights
    3.5 star property
    7.8/10 - Good (408 reviews)
    Roundtrip • New York (EWR) - Cartagena (CTG)
    EWR - CTG • 1 stop CTG - EWR • 1 stop
    Save 100% on your flight
    $2,005
    $1,033
    per traveler
    found 1 day ago
    Decameron Barú, A Trademark All Inclusive

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most.
A coastal cityscape with a prominent cathedral and modern skyscrapers.

Cartagena Walled City

Cartagena Walled City is known for its ample dining options, and you can make a stop by Clock Tower and Bolivar Square while in the area.

A coastal cityscape with high-rise buildings and a beach.

Bocagrande

Boasting the city's most prominent hotels, this upscale area offers shopping at Plaza Bocagrande and Nao Mall, and is close to the popular Ciudad Amurallada. Enjoy various dining options and easy access to the Transcaribe station.

A coastal town with a prominent church featuring a tall bell tower and a domed roof.

Getsemani

Travelers come to Getsemani for its abundant dining options, and you can see top attractions like Plaza de la Trinidad and Los Pegasos Dock while you're in town.

A coastal cityscape with historic buildings, a marina, and a prominent church tower.

Cartagena Centro

Unique features of Cartagena Centro include the museums and historic sites. Make a stop by Plaza Santo Domingo or Bolivar Square while you're exploring the area.

A narrow street with buildings on either side, a horse-drawn cart, and a prominent church tower in the background.
Photo by Botak Jon
Open Photo by Botak Jon

San Diego

San Diego is known for its ample dining options, and you can make a stop by House of Gabriel Garcia Marquez and Las Bovedas while in the area.

Santa Clara Hotel Deals

A rooftop terrace with a city skyline view, wooden wall, and potted plants.

Hotel Avenida Buenos Aires

Hotel Avenida Buenos Aires
3.0 star property
1.6 mi from Santa Clara
8.4 out of 10, Very good, (66 reviews)
"Nice Hotel!"
$49 nightly
The price is $49
Nov 11 - Nov 12
Hotel Avenida Buenos Aires
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Santa Clara
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.