Santa Cruz Vacation Rentals

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Vacation Rentals in Santa Cruz

Terrace/patio
Beautiful apartment 5 minutes from downtown Boquete

Beautiful apartment 5 minutes from downtown Boquete

Boquete
9.8 out of 10, Exceptional, (9)
"Thank you Jerry, your place was just perfect for us. Awesome location, so quiet, and in a lovely setting. We enjoyed the kitchen and cooking a few of our own meals. You sure are living in a paradise in Boquete. We will be back."
Canada
wendy m.
Beautiful apartment 5 minutes from downtown Boquete
Exterior
Linda Vista Cabins

Linda Vista Cabins

3.0 star property
Alto Boquete
9.2 out of 10, Wonderful, (17)
"Property was the best local accommodation I have had in Panama. The host was outstanding. "
United States
Don
$50 nightly
The price is $55
Jan 1 - Jan 2, 2026
Total with taxes and fees
Linda Vista Cabins
Family Chalet | Living area
Parque Central

Parque Central

2.0 star property
La Concepción
Parque Central
Family House, 2 Bedrooms, Garden View | Living area | Flat-screen TV
Casa Little Italy

Casa Little Italy

3.0 star property
Tijeras
6.0 out of 10, (1)
"Didn't accept credit card payment "
Mexico
ANGELO
Casa Little Italy
Exterior
Volcano View Cottage

Volcano View Cottage

Volcán
9.4 out of 10, Exceptional, (3)
"I was alone, but this casita would be perfect for a couple. The owner, Antonio, was quick to respond to any issues. I would definitely stay there again."
United States
John E.
$82 nightly
The price is $82
Dec 11 - Dec 12
Total with taxes and fees
Volcano View Cottage
Terrace/patio
King bed & hot tub in cloud forest mountains

King bed & hot tub in cloud forest mountains

Nueva California
King bed & hot tub in cloud forest mountains
Fridge, microwave, stovetop, coffee/tea maker
Fully Loaded and Comfortable House With Parking

Fully Loaded and Comfortable House With Parking

Panama City
Fully Loaded and Comfortable House With Parking
Exterior detail
Copeyhousechiriquí

Copeyhousechiriquí

Volcán
$88 nightly
The price is $92
Dec 2 - Dec 3
Total with taxes and fees
Copeyhousechiriquí
Exterior
Cabin inside cloudforest “PILA” floor 1

Cabin inside cloudforest “PILA” floor 1

Cerro Punta
$167 nightly
The price is $167
Dec 2 - Dec 3
Total with taxes and fees
Cabin inside cloudforest “PILA” floor 1
View from property
Casa Mirandita

Casa Mirandita

3.0 star property
Volcan
Casa Mirandita
Living area
Cabin in Cerro Punta 6BR, Fireplace, Hiking

Cabin in Cerro Punta 6BR, Fireplace, Hiking

Cerro Punta
$473 nightly
The price is $473
Dec 2 - Dec 3
Total with taxes and fees
Cabin in Cerro Punta 6BR, Fireplace, Hiking
Property grounds
Unique eco-cabin inside cloudforest “PILA”

Unique eco-cabin inside cloudforest “PILA”

Cerro Punta
$235 nightly
The price is $235
Dec 2 - Dec 3
Total with taxes and fees
Unique eco-cabin inside cloudforest “PILA”
Living area
Cabin inside International Park “PILA”

Cabin inside International Park “PILA”

Cerro Punta
$167 nightly
The price is $167
Dec 2 - Dec 3
Total with taxes and fees
Cabin inside International Park “PILA”
Exterior
Eco-Cabin apartment inside Cloudforest

Eco-Cabin apartment inside Cloudforest

Cerro Punta
$177 nightly
The price is $177
Dec 2 - Dec 3
Total with taxes and fees
Eco-Cabin apartment inside Cloudforest
Private kitchen
Casa Ideal Para Familia Pequeña en Lugar Tranquilo

Casa Ideal Para Familia Pequeña en Lugar Tranquilo

Tijeras
Casa Ideal Para Familia Pequeña en Lugar Tranquilo
Property grounds
Cozy Home Volcan, family residence in Volcan, ideally located.

Cozy Home Volcan, family residence in Volcan, ideally located.

Volcán
Cozy Home Volcan, family residence in Volcan, ideally located.
Exterior
Eco-Cabin in Cerro Punta

Eco-Cabin in Cerro Punta

Cerro Punta
Eco-Cabin in Cerro Punta
Interior
Potrerillos Ranch close to Boquete

Potrerillos Ranch close to Boquete

Chiriqui
Potrerillos Ranch close to Boquete
Terrace/patio
Cabin inside cloudforest “PILA”

Cabin inside cloudforest “PILA”

Cerro Punta
Cabin inside cloudforest “PILA”
Property grounds
Cabañas Mountain View

Cabañas Mountain View

Volcán
Cabañas Mountain View
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Risco de Hugo

Risco de Hugo

10/10 Excellent
"Views were incredible, room nicely apponted. Road to get there is bumpy."
Tamara 3-night trip
Posted 6 days ago
Risco de Hugo

Find out more about Santa Cruz

Everything you need to know about Santa Cruz vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Cruz vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $55 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Cruz rentals

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we give you a choice of vacation rentals near top local attractions in Santa Cruz, or you can select a secluded option if you're looking for relaxation.

What's the top vacation rental that Santa Cruz has to offer?

Casa Little Italy: This vacation home rental outside of Santa Cruz offers a balcony, a terrace, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a garden.

What’s there to see and do in Santa Cruz?

While you're exploring the area, Las Cavernas de Corredores and Área Silvestre Protegida Lagunas de Volcán are a couple of picturesque spots to get outside and enjoy nature. Barriles and Paradise Tropical Garden are a couple of places you'll find in the larger area.

What’s a vacation rental in Santa Cruz like?

A vacation rental is a private property you can book for a couple of days or more in Santa Cruz. Vacation rentals provide amenities like kitchens and laundry facilities so you'll have everything you want. If you're concerned about a clean environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you to travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for a family trip.