Search Vacation Homes in Santee

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Jan 23 - Jan 25
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Feb 20 - Feb 22

Our top choices for Santee vacation homes

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Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (37)
"Amazing host, comfy furniture, the fenced in yard was perfect for our fur babies! Hope to stay here again. 1.2 miles away from I-95! "
United States
Lauren B.
$356 nightly
The price is $395
Dec 27 - Dec 28
Total with taxes and fees
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Fridge, microwave, oven, stovetop
Charming 2-bedroom townhome with AC and WiFi in peaceful Summerton

Charming 2-bedroom townhome with AC and WiFi in peaceful Summerton

Charming 2-bedroom townhome with AC and WiFi in peaceful Summerton
Summerton
$287 nightly
The price is $319
Jan 4 - Jan 5, 2026
Total with taxes and fees
Charming 2-bedroom townhome with AC and WiFi in peaceful Summerton
Outdoor dining
Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.0 out of 10, Wonderful, (4)
"Nice and quiet property. It served us well for the weekend "
United States
Mick S.
$253 nightly
The price is $280
Dec 23 - Dec 24
Total with taxes and fees
Beautiful brick home w/ large porch and 3 bedrooms
Terrace/patio
Sweet Marion - Dock + Boat Ramp + Hot Tub!

Sweet Marion - Dock + Boat Ramp + Hot Tub!

Sweet Marion - Dock + Boat Ramp + Hot Tub!
Summerton
8.6 out of 10, Excellent, (18)
"Group of us older guys went for a golf weekend at Santee. The house was great and we really enjoyed our stay."
United States
Chris D.
$412 nightly
The price is $468
Jan 4 - Jan 5, 2026
Total with taxes and fees
Sweet Marion - Dock + Boat Ramp + Hot Tub!
Fridge, microwave, oven, stovetop
Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion
Summerton
$375 nightly
The price is $426
Dec 23 - Dec 24
Total with taxes and fees
Turtle Cove - Lake Living on Lake Marion
Exterior detail
The Tee Vee Cove is the place to be located near great golfing, fishing and food

The Tee Vee Cove is the place to be located near great golfing, fishing and food

The Tee Vee Cove is the place to be located near great golfing, fishing and food
2.0 star property
Elloree
$240 nightly
The price is $266
Dec 23 - Dec 24
Total with taxes and fees
The Tee Vee Cove is the place to be located near great golfing, fishing and food
Property grounds
Reel Haven on the Water: Modern + Comfy Home!

Reel Haven on the Water: Modern + Comfy Home!

Reel Haven on the Water: Modern + Comfy Home!
Eutawville
6.8 out of 10, (5)
"Perfect place for a weekend fishing trip. Owner was responsive. Slept 6 easily. Only stayed one night but was a perfect fit"
United States
brandon h.
$364 nightly
The price is $414
Dec 23 - Dec 24
Total with taxes and fees
Reel Haven on the Water: Modern + Comfy Home!
Interior
Marvelous Manning - 4Bdr + Game Room +Waterfront!

Marvelous Manning - 4Bdr + Game Room +Waterfront!

Marvelous Manning - 4Bdr + Game Room +Waterfront!
2.0 star property
Shad Moss village
$560 nightly
The price is $636
Jan 12 - Jan 13, 2026
Total with taxes and fees
Marvelous Manning - 4Bdr + Game Room +Waterfront!
1 bedroom, in-room safe, WiFi, bed sheets
Private entrance charming room with clawfoot tub.

Private entrance charming room with clawfoot tub.

Private entrance charming room with clawfoot tub.
Elloree
4.0 out of 10, (1)
"This pains me to write because this could’ve been a great little stopping point, however the bathtub was actually filthy. It smelled like urine and there is a dark grey film that needs to be scrubbed off. I get that old tubs can have stains but these are not stains and could’ve been removed with cleaner and elbow grease. I had camped for a week and just wanted to take a nice hot bath; I did not get to take one. Also I would add a sign for the cottage because it was confusing as to which door it...
United States
Gregory P.
$190 nightly
The price is $211
Dec 23 - Dec 24
Total with taxes and fees
Private entrance charming room with clawfoot tub.
Interior
Marvelous Manning: 4-Bdr + Studio + Waterfront

Marvelous Manning: 4-Bdr + Studio + Waterfront

Marvelous Manning: 4-Bdr + Studio + Waterfront
2.0 star property
Shad Moss village
$705 nightly
The price is $801
Jan 12 - Jan 13, 2026
Total with taxes and fees
Marvelous Manning: 4-Bdr + Studio + Waterfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santee Hotel Reviews

Baymont by Wyndham Santee

Baymont by Wyndham Santee

10/10 Excellent
"Very friendly staff. Room was clean."
Barbara 1-night trip
Posted 3 days ago
Baymont by Wyndham Santee

Find out more about Santee

Santee Vacation Homes information

Number of reviews
60
Accommodation
76 Vacation Homes
Lowest Price
$211
Highest Price
$801

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